Multi-quadrupole ICP-MS Analysis of the Elemental Composition in Raw Materials and Cell Culture Media

Introduction

Controlling the composition and quality of raw materials and cell culture media as well as understanding their impact on the production yield is becoming important with an increase in the number of biologic modalities such as mAbs and vaccines as therapeutics in the pharmaceutical end market.

Inductively coupled plasma–mass spectrometry (ICP-MS) for multi-element analysis is an excellent analytical tool for understanding of the impact of elements in the biologics yield and has the potential to serve as a powerful technology in biopharmaceutical upstream process development and batch quality control in manufacturing.

Watch this webinar for a discussion of a validated methodology that can tolerate high-matrix samples while simultaneously quantifying the high- and low-level elemental species using the NexION 5000 multi-quadrupole ICP-MS in raw materials and cell culture media used in biologics production.