The ability to monitor and visualize biological targets, pathways, and processes to obtain physiologically relevant timepoints in the context of the living system is crucial in preclinical research. The flexibility of acquiring multiple “snap-shots” during the in vivo phase of the experiment allows you to better track biological events and determine the optimal times for ex vivo phase endpoints such as histology, blood chemistry analysis and ELISA assays. Using probes such as MMPSense® fluorescent agents can help you to acquire new and useful data that would otherwise be missed using standard endpoint measurements as well as maximizing time, animal resources and cost.