NexION 1000 ICP Mass Spectrometer

Rice represents a dietary staple for over half of the world's population. However, in recent years, concerns have been raised over the presence of high levels of arsenic (As), where this carcinogenic metalloid can be accumulated at levels far exceeding ambient concentrations. Since China is the world's largest producer of rice, the Chinese government released a national standard method in 2014 for food safety – GB 5009.11– to aid the evaluation of As species in rice and rice products. In this document, HPLC-ICP-MS is identified as the preferred analytical technique.

In this study, five arsenic species were characterized in a commercial rice sample and certified reference material using a gradient anion-exchange method in accordance with GB 5009.11. The analysis was performed using a PerkinElmer NexSAR^™ HPLC-ICP-MS speciation solution, consisting of a NexSAR inert HPLC coupled to a NexION^® ICP-MS.

Concern about air pollution has been growing rapidly, with most of the focus on gaseous pollutants. Airborne particulates, especially small ones, are rapidly gaining attention due to their impact on human health, as smaller particles can be carried over long distances by wind and penetrate deep into the lungs, where contaminants can have direct interaction with lung tissue and the associated blood vessels. Airborne particulates are classified as PM₁₀ for those with aerodynamic diameters less than 10 µm and PM_2.5 for those with aerodynamic diameters less than 2.5 µm.

PM_2.5 regulations have been implemented throughout the world, and in order to implement a regime to reduce the concentration of PM_2.5, it is important to determine the origins of these particulates, hence the need to collect and analyze them.

ICP-MS is often the analytical instrument of choice for such applications due to its low detection limits and wide linear dynamic range. This work describes the collection, sample preparation and inorganic elemental analysis of atmospheric PM₁₀ and PM_2.5 using PerkinElmer’s NexION^® ICP-MS.

Toxic cyanobacterial blooms were reported worldwide in various aquatic systems, including freshwater rivers, lakes, reservoirs, and eutrophied coastal marine habitats. Cyanobacterial blooms might be caused by a combination of multiple factors, including eutrophication, solar radiation, temperature, current patterns and other associated factors. Their proliferation in aquatic environments can cause death or toxin accumulation in aquatic animals and then, indirectly or directly, affect human health. Microcystis aeruginosa (M. aeruginosa) bloom is the most common harmful algal bloom (HAB) and is widely studied in various fields.

Copper sulfate is an algaecide frequently used for controlling algae growth. The mechanism of copper (Cu)-based algaecide for algal bloom control is not well understood. The amount of Cu required to kill an individual algae cell and the morphology of the cell after being killed is still unknown. Quantification measurement of these phenomena is even more difficult due to the lack of appropriate methodology.

This work demonstrates that single cell (SC)-ICP-MS provides an effective method for the determination of copper algaecide at the cellular level, leveraging the NexION^® ICP-MS with Syngistix^™ Single Cell Application software module.

This application note presents a high throughput method evaluating 27 analytes in drinking water following U.S. EPA 200.8 with a 3-5 fold reduction in sample analysis time through the use of the HTS high throughput sample introduction system fully integrated with the NexION^® ICP-MS and Syngistix^™ for ICP-MS software.

This work demonstrates a robust method using SP-ICP-MS technology to detect CeO2 NPs which were extracted from soil samples with tetrasodium pyrophosphate (TSPP). Over the past few decades, engineered nanoparticles (ENPs) have been increasingly used in many commercial products. As a result, more and more ENPs have been released into the environment, which raises concerns over their fate, toxicity and transport therein.

The most significant challenge in trace element analysis of drinking water is ensuring detection capability that complies with the regulatory framework at the same time as maximizing sample throughput. The NexION^® 1000 ICP-MS solves the challenges that high-throughout laboratories face using a robust, simple method and a single gas mixture. This application note explains how the NexION 1000 exceeds expectations on detection capability and details the benefits of using the single gas mixture for a wide range of elements, even those where the first ionization energy is relatively high (e.g. selenium).

In the textile industry, the use of titanium dioxide (TiO₂) nanoparticles (NPs) is increasing due to their ability to provide UV protection, increase the hydrophilic nature of fabrics, provide antibacterial characteristics, and reduce odors. This work demonstrates the ability of PerkinElmer's NexION^® Single Particle ICP-MS with Syngistix^™ Nano Application Software Module to both detect and measure TiO₂ nanoparticles released from textiles.

Eye drops are commonly used medications which are available both over-the-counter and as prescriptions in various forms. Because eye drops are classified as a parenteral medication and have relatively large daily doses, the inorganic components in eye drops must be present at low concentrations. As a result, ICP-MS is the most appropriate technique for the determination of trace elements in eye drops.

The International Conference on Harmonization Guideline for Elemental Impurities Q3D (ICH Q3D) has established maximum permitted daily exposure limits for elemental impurities in pharmaceutical products. This work discusses the sample preparation and analysis of Class 1, 2, and 3 elements in a variety of eye drops with the NexION ICP-MS, following the criteria defined in ICH Q3D. The developed methodology (both sample preparation and analytical) demonstrates both accuracy and stability.

Owing to the toxicity of heavy metals, it is increasingly important to test cannabis flowers and other cannabis derivatives so that patient and consumer safety is maintained as the use of cannabis becomes more common. This need has translated into an increasing demand for testing cannabis flowers and other cannabis derivatives for toxins such as the heavy metals cadmium (Cd), lead (Pb), arsenic (As), and mercury (Hg). In this application note, we present data to illustrate the successful validation of the Titan MPS^™ Microwave Sample Preparation System and the NexION^® ICP-MS for the determination of heavy metals in cannabis flower according to the validation protocols set in USP General Chapter <233>, which are commonly used for evaluation of the levels of elemental impurities in samples.

Gold nanoparticles (AuNPs) are widely used in industrial and medical applications. They are known to form naturally during the weathering of Au-bearing mineral deposits, as well as the transformation of gold nuggets and particles. In freshwater systems, they bioaccumulate in aquatic organisms, as shown on test fish species such as zebrafish and guppy.

Several techniques are available to determine gold concentrations in samples – however, few methods have been developed to characterize the size fractions of nanoparticulate gold in complex organic materials. This work is a feasibility study to measure AuNPs in complex organic matrices using Single Particle ICP-MS, as may be applied to environmental monitoring or exploration, demonstrating the ability of PerkinElmer’s NexION^® ICP-MS Single Particle Analyzer to reliably detect and characterize nanoparticles in soil and aquatic samples.

Single Particle (SP) ICP-MS is an analytical technique that has demonstrated tremendous potential for the measurement and characterization of metal-containing nanoparticles (NPs) in a wide range of sample types, including environmental. One of the most challenging matrices is seawater due to its high salt content, which causes severe difficulties when analyzed for NPs due to matrix suppression and cone clogging.

This work demonstrates the ability of the NexION^® ICP-MS, coupled to the dedicated Syngistix^™ Nano Application software module, to measure silver (Ag) nanoparticles in seawater and track their transformations over time.

Due to rising concerns over the carcinogenic properties of hexavalent chromium (Cr⁶⁺) in drinking water, many national and regional water standards are looking to lower the maximum allowable levels of total chromium and hexavalent chromium in potable waters. And in order to assess trace concentrations of Cr⁶⁺ in drinking water, it is necessary to have an instrument capable of measuring parts per trillion (ppt) concentrations of Cr and possessing a wide linear dynamic range – HPLC-ICP-MS is often the instrumentation of choice in such applications.

This work demonstrates an ion exchange method for the characterization of Cr⁶⁺ in potable drinking water using our NexSAR HPLC-ICP-MS Speciation Solution. Discover the advantages of the inert and metal-free fluid path of the NexSAR Inert HPLC coupled with the NexION^® ICP-MS’ Universal Cell Technology^™ for these types of analyses – download this application note.

Nanoparticles (NPs) have been of significant interest over the last two decades as they offer attractive benefits for drug delivery to overcome limitations in conventional chemotherapy. Nanoparticles can be engineered to carry both drugs and imaging probes to simultaneously detect and treat cancer. They may also be designed to specifically target diseased tissues and cells in the body. A number of nanoparticlebased cancer therapeutics have been approved for clinical use and/or are currently under development.

Testing for harmful metal(loid)s that may be included in raw materials, processes, paints and additives used in the manufacturing processes of children's toys has been mandated by the regulation EN 71-3. This regulation recommends specific testing methods and maximum allowable concentrations of leachable metals and metalloids such as Al, As, B, Ba, Cd, Co, Cr (III), Cr (VI), Cu, Hg, Mn, Ni, Pb, Sb, Se, Sn, organotin, Sr and Zn in parts of toys, with the exclusion of general packaging materials.

This work shows a method for the measurement of hexavalent chromium in different toy material categories in accordance with method EN 71-3 Category II, leveraging the unique combination and capabilities of the NexSAR^™ Inert HPLC coupled to the robust NexION^® ICP-MS.

This work investigated the transfer of Ag and CuO nanoparticles from consumer products via simulated dermal contact by using textile wipes as a surrogate using PerkinElmer’s NexION^® ICP-MS single particle analyzer with the unique Syngistix^™ Nano Application software module for data collection and analysis.

The grain industry is very complex. It’s global, diverse, and can also present analytical challenges. Today’s grain users demand more when it comes to quality, safety, and uniformity. In addition, they seek diverse products with unique characteristics.

PerkinElmer is equipped to help the grain industry in its quest to feed the world – nutritiously and economically. Our testing and analysis solutions encompass the three primary areas required for complete knowledge of grains and their derivatives – composition, functionality, and safety.

Food testing labs like yours are constantly challenged with accurately analyzing samples quickly and efficiently - all while striving to reduce costs due to market forces. Your commitment to ensuring meat and seafood are safe for consumption, as demand increases, is an uphill battle.

Our commitment to you: to provide a range of solutions across multiple technologies, products, and services that meets or exceeds the testing needs of food processors. Our solutions offer more efficiency and increased accuracy and sensitivity for better yields in real time with minimal training.

From instrumentation and software to consumables and reagents to service and support, we are dedicated to providing you with end-to-end solutions that ease your everyday challenges of automation, throughput, service, and time to results.

PerkinElmer's NexION 1000 ICP-MS is the ideal high-throughput system for running routine, multielemental, trace-level analyses that meet regulatory standards – and that works within your budget.

The International Conference on Harmonization Guideline for Elemental Impurities Q3D (ICH Q3D) has established maximum permitted daily exposure limits for elemental impurities in pharmaceutical products. In combination with the U.S. Pharmacopeia’s (USP) Chapters <232> and <233> on elemental impurities, they redefined how the pharmaceutical and related supply-chain industries will measure, document, and comply with strict new standards to limit the presence of elemental impurities in drug products.

PerkinElmer provides the tools and processes you need to take control of impurities testing for both drug substances and drug products, providing proven, reliable technology for the identification and quantification of elemental impurities and the accurate measurement of residual solvents in accordance with strict regulatory guidelines.

Download this brochure to learn more.

With instruments that are the industry standard worldwide, PerkinElmer accessories, consumables, methods and application support meet the most demanding requirements and are the preferred choice in thousands of laboratories globally.

Quality control-monitoring and testing are important in ensuring the quality of palm oil. The quality control parameters are used to judge the quality of palm oil products and it can be monitored and tested to ensure that the palm oil is not deliberately or accidentally adulterated.

The S20 series is the next generation of high-performance, robust, and agile autosamplers designed specifically for PerkinElmer’s spectroscopy platforms - atomic and molecular. The series is comprised of two autosamplers: the S23 with three racks and the S25 with five racks. They are designed to meet the needs of all types of laboratories requiring:

This guide provides a basic overview of the most commonly used atomic spectroscopy techniques and provides the information necessary to help you select the one that best suits your specific needs and applications.

PerkinElmer ICP-MS instruments are complete systems with the exception of the following items which must be provided by the customer: electrical power, exhaust vents, argon gas supplies with approved regulator, cell gas supply with approved regulators

Look to PerkinElmer for all of your consumables and supplies for your NexION 1000, 2000, or 5000 ICP-MS system.

Our High Throughput System (HTS) is a uniquely designed modular sample introduction that integrates with the NexION^® series of ICP-MS and the Avio^® series of ICP-OES to dramatically reduce sample-to-sample time, thereby improving sample throughput while maintaining operation simplicity. The HTS maximizes productivity by significantly reducing the time required for the sample uptake, stabilization, and washout.

This valve-driven system is fully integrated with the Syngistix platform, eliminating the need for third-party software. Using a metal-free fluid path, the system quickly delivers the sample to the plasma, providing excellent results. With simple programming and workflow, the NexION ICP-MS and Avio ICP-OES with HTS simplifies method development for high-throughput analyses, allowing you to dramatically increase the number of samples you can analyze per day.

PerkinElmer’s Syngistix Enhanced Security software for AA, ICP and ICP-MS meets the special needs of highly regulated labs such as those that must comply with the U.S. FDA’s 21 CFR Part 11 regulations.

PerkinElmer's Syngistix is a workflow-based software designed to offer a harmonized user experience

Product Certificate for the NexION 1000/2000

PerkinElmer's NexION 1000/2000’s patented RF generator combined with the novel design of the self-cooling LumiCoil RF coil provides a reliable plasma source for a wide range of demanding trace-element detection applications.