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NexION 1000 ICP Mass Spectrometer

The NexION® 1000 ICP-MS is the ideal high-throughput system for routine, multi-elemental, trace-level analyses that meet regulatory standards – and that works within your budget. It features a host of proprietary technologies that combine to deliver exceptional speed and operational simplicity, making your lab more efficient than ever before.

Part Number N8150048
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NexION 1000是一款专为高通量实验室打造的ICP-MS,非常适合用于常规的多元素痕量分析,它具备下列独特的技术和功能:

  • 专门设计的SMARTintro进样系统,配备全基体进样系统(AMS),高固溶含量样品可直接进样的同时保证了信号的长期稳定性。
  • 三重四极杆结构。通用池具有的独有能力,可利用一路气体同时实现碰撞模式和反应模式,有效去除干扰,切换时间非常短,有效提升您的检测效率。
  • 智能电子稀释功能(EDR),实现高、低含量元素一次进样同时分析。
  • 满足各种微观颗粒检测的,业内数据采集速率最快的检测器(100,000数据点/秒)。
  • 全新的固态射频发生器配备革命性的LumiCoil技术,实现业内首款无需主动冷却(水冷或风冷)和维护的射频线圈。
  • 三锥接口和四极杆离子偏转器,锥后质谱系统完全免维护。
  • Syngistix操作软件拥有直观的界面,您的操作从未如此简单:从左至右、图标化的界面始终指导着您的检测工作。此外,它还是一款跨平台的操作软件,让您轻松实现在不同的原子光谱仪器间的操作。

NexION 1000 ICP-MS——精准or高效?无需纠结。


21 CFR Part 11 Compatible Yes
Depth 69.0 cm
Height 75.0 cm
Model Name NexION 1000
Portable No
Product Brand Name NexION
Warranty 1 Year
Weight 150.0 kg
Width 81.0 cm
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Application Note

A Single Cell-ICP-MS Method to Study the Treatment Efficiency of Algaecide for Toxic Algal Bloom Control

Toxic cyanobacterial blooms were reported worldwide in various aquatic systems, including freshwater rivers, lakes, reservoirs, and eutrophied coastal marine habitats. Cyanobacterial blooms might be caused by a combination of multiple factors, including eutrophication, solar radiation, temperature, current patterns and other associated factors. Their proliferation in aquatic environments can cause death or toxin accumulation in aquatic animals and then, indirectly or directly, affect human health. Microcystis aeruginosa (M. aeruginosa) bloom is the most common harmful algal bloom (HAB) and is widely studied in various fields.

Copper sulfate is an algaecide frequently used for controlling algae growth. The mechanism of copper (Cu)-based algaecide for algal bloom control is not well understood. The amount of Cu required to kill an individual algae cell and the morphology of the cell after being killed is still unknown. Quantification measurement of these phenomena is even more difficult due to the lack of appropriate methodology.

This work demonstrates that single cell (SC)-ICP-MS provides an effective method for the determination of copper algaecide at the cellular level, leveraging the NexION® ICP-MS with Syngistix Single Cell Application software module.

Advantages of a High Throughput Sample Introduction System for Drinking Water Analyses Using ICP-MS

Water forms 80% of the human body and is essential to all life. Due to increasing pollution and land disturbance, vast quantities of potentially harmful elements are mobilized into potable water sources, such as rivers, lakes and groundwater. As such, the concentrations of elements, which are known to elicit a toxicological response, are regulated throughout the world by international and national regulations, of which one of the most commonly used methods is the United States Environmental Protection Agency 200.8 (EPA 200.8). Since all drinking waters need to be tested prior to distribution to ensure fitness for consumption, this makes sample loads on water-testing laboratories high.

This study presents a high throughput method evaluating 27 analytes in drinking water following EPA 200.8 with a 3-5 fold reduction in sample analysis time through the use of PerkinElmer’s High Throughput System (HTS), a novel high-volume sample introduction module that is fully integrated with the NexION ICP-MS.

Analysis of Cerium Dioxide Nanoparticles in Soil Using Single Particle ICP-MS

This work demonstrates a robust method using SP-ICP-MS technology to detect CeO2 NPs which were extracted from soil samples with tetrasodium pyrophosphate (TSPP). Over the past few decades, engineered nanoparticles (ENPs) have been increasingly used in many commercial products. As a result, more and more ENPs have been released into the environment, which raises concerns over their fate, toxicity and transport therein.

Analysis of Drinking Water using Universal Collision-Reaction Gas Technology on the NexION 1000 ICP-MS

Due to increasing urbanization, industrialization, mining, and farming practices within catchment areas, the need to monitor potable drinking water for hazardous components has increased in importance. Many countries have implemented stringent criteria which need to be met before water can be distributed for human use and consumption. This require that analytical instrumentation be capable of reaching low detection limits so that trace concentrations of elements can be accurately and precisely quantified.

Characterization of TiO2 Nanoparticle Release from Fabrics By Single Particle ICP-MS

In the textile industry, the use of titanium dioxide (TiO2) nanoparticles (NPs) is increasing due to their ability to provide UV protection, increase the hydrophilic nature of fabrics, provide antibacterial characteristics, and reduce odors. This work demonstrates the ability of PerkinElmer's NexION® Single Particle ICP-MS with Syngistix Nano Application Software Module to both detect and measure TiO2 nanoparticles released from textiles.

PDF 516 KB
Determination of Trace Elements in Eye Drops with the NexION ICP-MS

Eye drops are commonly used medications which are available both over-the-counter and as prescriptions in various forms. Because eye drops are classified as a parenteral medication and have relatively large daily doses, the inorganic components in eye drops must be present at low concentrations. As a result, ICP-MS is the most appropriate technique for the determination of trace elements in eye drops.

The International Conference on Harmonization Guideline for Elemental Impurities Q3D (ICH Q3D) has established maximum permitted daily exposure limits for elemental impurities in pharmaceutical products. This work discusses the sample preparation and analysis of Class 1, 2, and 3 elements in a variety of eye drops with the NexION ICP-MS, following the criteria defined in ICH Q3D. The developed methodology (both sample preparation and analytical) demonstrates both accuracy and stability.

PDF 475 KB
Digestion, Testing, and Validation of Heavy Metals in Cannabis

Owing to the toxicity of heavy metals, it is increasingly important to test cannabis flowers and other cannabis derivatives so that patient and consumer safety is maintained as the use of cannabis becomes more common. This need has translated into an increasing demand for testing cannabis flowers and other cannabis derivatives for toxins such as the heavy metals cadmium (Cd), lead (Pb), arsenic (As), and mercury (Hg). In this application note, we present data to illustrate the successful validation of the Titan MPS™ Microwave Sample Preparation System and the NexION® ICP-MS for the determination of heavy metals in cannabis flower according to the validation protocols set in USP General Chapter <233>, which are commonly used for evaluation of the levels of elemental impurities in samples.

Monitoring the Fate of Silver Nanoparticles in Seawater Using Single Particle ICP-MS

Single Particle (SP) ICP-MS is an analytical technique that has demonstrated tremendous potential for the measurement and characterization of metal-containing nanoparticles (NPs) in a wide range of sample types, including environmental. One of the most challenging matrices is seawater due to its high salt content, which causes severe difficulties when analyzed for NPs due to matrix suppression and cone clogging.

This work demonstrates the ability of the NexION® ICP-MS, coupled to the dedicated Syngistix Nano Application software module, to measure silver (Ag) nanoparticles in seawater and track their transformations over time.

Quantification of Low Levels of Hexavalent Chromium in Water Using a NexSAR HPLC-ICP-MS

Due to rising concerns over the carcinogenic properties of hexavalent chromium (Cr6+) in drinking water, many national and regional water standards are looking to lower the maximum allowable levels of total chromium and hexavalent chromium in potable waters. And in order to assess trace concentrations of Cr6+ in drinking water, it is necessary to have an instrument capable of measuring parts per trillion (ppt) concentrations of Cr and possessing a wide linear dynamic range – HPLC-ICP-MS is often the instrumentation of choice in such applications.

This work demonstrates an ion exchange method for the characterization of Cr6+ in potable drinking water using our NexSAR HPLC-ICP-MS Speciation Solution. Discover the advantages of the inert and metal-free fluid path of the NexSAR Inert HPLC coupled with the NexION® ICP-MS’ Universal Cell Technology for these types of analyses – download this application note.

Quantification of Nanoparticle Uptake into Cancer Cells using Single Cell ICP-MS

Nanoparticles (NPs) have been of significant interest over the last two decades as they offer attractive benefits for drug delivery to overcome limitations in conventional chemotherapy. Nanoparticles can be engineered to carry both drugs and imaging probes to simultaneously detect and treat cancer. They may also be designed to specifically target diseased tissues and cells in the body. A number of nanoparticlebased cancer therapeutics have been approved for clinical use and/or are currently under development.

PDF 939 KB
Speciation of Hexavalent Chromium in Children's Toys According to EN 71-3 Category II with the NexSAR HPLC-ICP-MS

Testing for harmful metal(loid)s that may be included in raw materials, processes, paints and additives used in the manufacturing processes of children's toys has been mandated by the regulation EN 71-3. This regulation recommends specific testing methods and maximum allowable concentrations of leachable metals and metalloids such as Al, As, B, Ba, Cd, Co, Cr (III), Cr (VI), Cu, Hg, Mn, Ni, Pb, Sb, Se, Sn, organotin, Sr and Zn in parts of toys, with the exclusion of general packaging materials.

This work shows a method for the measurement of hexavalent chromium in different toy material categories in accordance with method EN 71-3 Category II, leveraging the unique combination and capabilities of the NexSAR Inert HPLC coupled to the robust NexION® ICP-MS.

PDF 918 KB
Transport of Nanoparticles From Coated Surfaces Through Physical Contact

This work investigated the transfer of Ag and CuO nanoparticles from consumer products via simulated dermal contact by using textile wipes as a surrogate using PerkinElmer’s NexION ICP-MS single particle analyzer with the unique Syngistix Nano Application software module for data collection and analysis



Grain Testing Solutions Brochure

The grain industry is very complex. It’s global, diverse, and can also present analytical challenges. Today’s grain users demand more when it comes to quality, safety, and uniformity. In addition, they seek diverse products with unique characteristics.

PerkinElmer is equipped to help the grain industry in its quest to feed the world – nutritiously and economically. Our testing and analysis solutions encompass the three primary areas required for complete knowledge of grains and their derivatives – composition, functionality, and safety.

NexION 1000 ICP Mass Spectrometer Brochure

PerkinElmer's NexION 1000 ICP-MS is the ideal high-throughput system for running routine, multielemental, trace-level analyses that meet regulatory standards – and that works within your budget.

PDF 1001 KB
USP <232>/<233> & ICH Q3D Capabilities Brochure

The International Conference on Harmonization Guideline for Elemental Impurities Q3D (ICH Q3D) has established maximum permitted daily exposure limits for elemental impurities in pharmaceutical products. In combination with the U.S. Pharmacopeia’s (USP) Chapters <232> and <233> on elemental impurities, they redefined how the pharmaceutical and related supply-chain industries will measure, document, and comply with strict new standards to limit the presence of elemental impurities in drug products.

PerkinElmer provides the tools and processes you need to take control of impurities testing for both drug substances and drug products, providing proven, reliable technology for the identification and quantification of elemental impurities and the accurate measurement of residual solvents in accordance with strict regulatory guidelines.

Download this brochure to learn more.



Atomic Spectroscopy 2018-2019 Consumables & Supplies Catalog

With instruments that are the industry standard worldwide, PerkinElmer accessories, consumables, methods and application support meet the most demanding requirements and are the preferred choice in thousands of laboratories globally.



Atomic Spectroscopy, A Guide to Selecting the Appropriate Technique and System

This guide provides a basic overview of the most commonly used atomic spectroscopy techniques and provides the information necessary to help you select the one that best suits your specific needs and applications.

NexION 1000/2000 ICP-MS Consumables & Supplies Guide

Look to PerkinElmer for all of your consumables and supplies for your NexION 1000 or 2000 ICP-MS system.

NexION 1000/2000 ICP-MS Preparing Your Laboratory

PerkinElmer ICP-MS instruments are complete systems with the exception of the following items which must be provided by the customer: electrical power, exhaust vents, argon gas supplies with approved regulator, cell gas supply with approved regulators


Product Note

Syngistix Atomic Spectroscopy Enhanced Security Software Product Note

PerkinElmer’s Syngistix Enhanced Security software for AA, ICP and ICP-MS meets the special needs of highly regulated labs such as those that must comply with the U.S. FDA’s 21 CFR Part 11 regulations.

Syngistix Cross-Platform Atomic Spectroscopy Software

PerkinElmer's Syngistix is a workflow-based software designed to offer a harmonized user experience


Regulatory Compliance Certification

NexION 1000/2000 Product Certificate

Product Certificate for the NexION 1000/2000


Technical Note

Advantages of a Novel Plasma Generator for the NexION 2000 ICP-MS

PerkinElmer's NexION 1000/2000’s patented RF generator combined with the novel design of the self-cooling LumiCoil RF coil provides a reliable plasma source for a wide range of demanding trace-element detection applications.

PDF 906 KB
All Matrix Solution System for NexION ICP-MS Platforms

PerkinElmer’s All Matrix Solution system provides a number of benefits to simplify analysis of high-matrix samples with the NexION family of ICP-MS instruments.