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NexION 5000 Multi-Quadrupole ICP Mass Spectrometer for Non-Cleanroom Applications

R&D 100 Award winner NexION 5000 ICP-MS

The NexION® 5000 multi-quadrupole ICP-MS – the first in its category to boast four quads – is innovatively designed to meet and exceed the demanding requirements of ultra-trace elemental applications. It takes ICP-MS performance beyond traditional triple quad to deliver exceptionally low background equivalent concentrations and outstanding detection limits, key to ensuring accurate, repeatable results. Plus, the NexION 5000 provides superior interference removal, phenomenal stability and unmatched matrix tolerance, for performance you can rely on.

In addition to boasting four quads, the NexION 5000 is also the proud recipient of three awards: Wiley Analytical Science Award, The Analytical Scientist Innovation Award, and R&D 100 Award.

Part Number
Model Name
Technology Type
NexION 5000 Cleanroom ICP-MS
Multi-Quad ICP-MS for Cleanroom Applications
NexION 5000 Non-Cleanroom ICP-MS
Multi-Quad ICP-MS for Non-Cleanroom Applications
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The NexION 5000 Non-Cleanroom ICP-MS is highly recommended for applications which do not require the use of a cleanroom, but which still benefit from the unmatched sensitivity and interference removal capabilities of the NexION 5000 series. It features a host of new and proprietary technologies that deliver outstanding detection limits, astounding accuracy, excellent repeatability and the long-term stability required by your applications:

  • Four quadrupoles:
    • First: Quadrupole Ion Deflector (Q0) directs ions to the entrance of the first mass filter
    • Second: Transmission Analyzer Quadrupole 1 (Q1, full-sized for <0.7 amu mass resolution), acts as a mass filter or as an ion guide to direct ions to the Quadrupole Universal Cell
    • Third: Quadrupole Universal Cell (Q2), empowered by dynamic bandpass tuning, prevents side reactions with residual reaction gases in the cell
    • Fourth: Transmission Analyzer Quadrupole 2 (Q3, full-sized for <0.7 amu mass resolution), acts as a mass filter or as an ion guide to direct ions to the detector
  • Extended Dynamic Range (EDR) increases linear dynamic range to 1012, allowing the accurate analysis of both high- and low-concentration analytes in a single analytical run, resulting in fewer re-runs
  • Low maintenance for greater uptime:
    • Triple Cone Interface with patent-pending OmniRing combined with Quadrupole Ion Deflector deliver no maintenance beyond cones, for continual operation and improved stability
    • 34 MHz free-running RF generator offers trouble-free user experience - the plasma is generated by the unique LumiCoil RF load coil, which is air cooled (does not require water or gas cooling), so maintenance-free, eliminating need to replace plasma load coils
  • External status lighting provides easy visibility of state of analysis, optimizing efficiencies
  • Syngistix for ICP-MS software (v. 3.0 or higher) brings together the power of the triple-quad ion optics with automated startup, optimization, batch analysis and shutdown, user-friendly workflows, and more in a contemporary user interface


Depth 85.0 cm
Height 85.0 cm
Model Name NexION 5000 Non-Cleanroom ICP-MS
Product Brand Name NexION
Technology Type Multi-Quad ICP-MS for Non-Cleanroom Applications
Weight 191.0 kg
Width 114.0 cm
Resources, Events & More
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Application Brief

Determination of Heavy Metals in Cassava Flours Using NexION ICP-MS Following U.S. FDA EAM 4.7 Method

Cassava is a root vegetable and a major source of calories and carbohydrates in many countries around the globe. As one of the most important staple crops, its levels of harmful chemicals and pathogens are strictly controlled – these include organic chemicals and heavy metals. Metals, such as cad ...

Determination of Organotin in Tap Water by HPLC-ICP-MS in Accordance with Chinese Method HJ 1074-2019

Organotin compounds are widely used across industry and agriculture, resulting in widespread pollution of various environmental media, including potable water. Among these compounds are tributyltin (TBT), triphenyltin (TPT), dibutyltin (DBT), and diphenyltin (DPT), in the following order of persi ...

PDF 506 KB
PM10 and PM2.5 Air Pollution Monitoring and Source Apportionment in Asia Using the NexION ICP-MS

Concern about air pollution has been growing rapidly, with most of the focus on gaseous pollutants. Airborne particulates, especially small ones, are rapidly gaining attention due to their impact on human health, as smaller particles can be carried over long distances by wind and penetrate deep i ...


Application Note

Analysis of Blood Using NexION 5000 ICP-MS

For many years, inductively coupled plasma mass spectrometry (ICP-MS) has been the tool of choice for the trace analysis of elements like lead (Pb), arsenic (As), mercury (Hg), and copper (Cu) in bodily fluids such as urine, blood, serum and saliva, as well as in tissues.

Blood and serum ar ...

Analysis of Samples Rich in Rare Earth Elements Prepared by Lithium Borate Fusion on the NexION 5000 ICP-MS

Rare earth elements (REEs) have many uses in the advanced technology and electronics that are utilized in automobiles, airplanes, camera lenses, medical devices, televisions, smartphones, and computers, to name a few. With the growing demand for REEs to support technological advancement, the sear ...

Determination of Bromine in Ultra-High-Purity Copper using the NexION 5000 ICP-MS

Copper (Cu) is widely used due to its high electrical and thermal conductivity, strong corrosion resistance, excellent workability and moderate strength. It is one of the few metals used most commonly in its pure form, and ultra-pure copper specifically is the standard material used in the bondin ...

Determination of Impurities in Lithium Materials with the NexION 5000 ICP-MS

The capability to identify the presence of impurities in lithium (Li) battery materials is critical for manufacturers and suppliers to ensure that the performance of the final battery is not compromised. Li salts used in battery production are generally extracted from brines and, subsequently, ha ...

PDF 639 KB
Determination of Rare Earth Impurities in High-Purity CeO2 with NexION 5000 ICP-MS per Chinese Method GB/T 18115.2-2020

With the development of optoelectronic communication technology, the demand for radio and television materials is increasing, especially that of high-purity rare earths. As such, rare earth elements (REEs) are often referred to as “industrial vitamins”. In these applications, the purity of the RE ...

PDF 278 KB
Determination of Toxic and Other Trace Elements in Baby Foods Using the NexION ICP-MS

For many children around the globe, commercial baby foods are the main source of nutrients and energy, and therefore their quality and safety are critical and must be monitored. In March 2021, the U.S. House of Representatives introduced the “Baby Food Safety Act of 2021” to regulate the presence ...

PDF 699 KB
Direct Analysis of Trace Elements in Open-Ocean Seawater using the NexION 5000 ICP-MS

Due to high total dissolved solids (TDS), seawater is considered one of the most difficult matrices to analyze for the presence of heavy metals and other trace elements. Plus, trace elements in open-ocean seawater are even lower than in coastal areas, thus are more challenging to accurately measu ...

Direct Determination of Rare Earth Impurities in High-Purity Gadolinium Oxide with the NexION 5000 ICP-MS

Gadolinium (Gd) is commonly used in the production of magnetic compounds. Another application is in Mg-Gd-based alloys, which are used primarily for their excellent corrosion-resistance properties, and it is for this reason that they can be used in many other applications which require high-stren ...

Direct Determination of Rare Earth Impurities in High-Purity Neodymium Oxide with the NexION 5000 ICP-MS

Since the purity of the rare earth elements (REEs) governs their efficacy and the price, it is of great interest to produce ultra-high purity rare earth oxides. Neodymium oxide (Nd2O3) is one such REE and is mainly used as a colorant for glass and ceramics, a raw material fo ...

Direct Determination of Rare Earth Impurities in High-Purity Ytterbium Oxide with the NexION 5000 ICP-MS

Rare earth elements (REEs) are crucial components in many advanced materials for industrial use, as well as consumer electronics. As the properties and prices of REEs are dependent on their purity, it is of great interest to produce rare earth oxides of high purity. High-purity ytterbium oxide (Y ...

Direct Determination of Trace Rare Earth Impurities in High-Purity Europium Oxide using the NexION 5000 ICP-MS

Rare earth elements (REEs) exhibit many optical, electrical, and magnetic properties, and therefore play an irreplaceable role in high-tech photoelectromagnetic materials. At present, the widely used color TV phosphors, Ni-H batteries, high-performance magnetic materials, etc. are all examples of ...

Direct Determination of Trace Rare Earth Impurities in High-Purity Praseodymium Oxide with the NexION 5000 ICP-MS

Rare earth elements (REEs) are often referred to as "industrial vitamins", as they are used in a variety of traditional industrial fields as well as in new materials. A particularly important application of some REEs, for example high-purity praseodymium oxide (Pr6O11), is t ...

Direct Trace-Element Analysis in Cell Culture Media and Raw Materials with the NexION 5000 ICP-MS

Raw material preparation and formulation is a known source of elemental content and variation in cell culture media. Other sources of trace metal concentrations and variability include the leaching of trace metals from bioreactors, preparation vessels and storage containers. Quality control in ce ...

PDF 756 KB
Lead and Strontium Isotope Ratio Analysis Using the NexION 5000 ICP-MS

Isotope ratio measurements are used in many application fields, such as nuclear, geological, geochronological dating, clinical, and others. Depending on the industry, there is interest in measuring natural, depleted, or enriched isotope ratios and exact abundances of all isotopes for the element( ...

PDF 665 KB
Measurement of Impurities in High-Purity Copper Concentrate using the NexION 5000 ICP-MS

Most of the copper (Cu) concentrates produced globally contain some impurities, which can affect the price as copper concentrates containing high levels of impurities are not accepted by some smelters. To permit treatment and to maximize the value of a Cu concentrate, the levels of impurities in ...



NexION 5000 Multi-Quadrupole ICP-MS - Interactive Brochure

In the fast-paced analytical world, accurate and reproducible results are essential to guaranteeing quality and ensuring safety. What many industries have in common is the need for trace-element analysis with superior interference removal, extremely low detection limits, and outstanding backgroun ...



New Developments in Multi-Quadrupole ICP-MS Technology for Challenging Applications

Laboratories conducting trace-elemental analyses require high-performance instrumentation capable of delivering accurate and reproducible results, even at low concentrations. Find out how recent developments in multi-quadrupole ICP-MS technology address these evolving needs.

  • Advantages ...

NexION 5000 Multi-Quadrupole ICP-MS - Digest of Application Spotlights

Welcome to the application digest for PerkinElmer’s NexION® 5000 Multi-Quadrupole ICP-MS.

The multi-award-winning NexION 5000 is the industry’s first and only four-quadrupole ICP-MS system, engineered to remove the most complex interferences and address the most challenging a ...



NexION 5000 ICP-MS – Innovation Recognized

Perfect for your most challenging applications, the cutting-edge, multi-award-winning NexION® 5000 Multi-Quadrupole ICP-MS is the industry’s first and only four-quadrupole ICP-MS instrument – taking performance well beyond everyday triple-quad technology. And the scientific community i ...

PDF 204 KB


Atomic Spectroscopy - A Guide to Selecting the Appropriate Technique and System

Atomic spectroscopy is a family of techniques for determining the elemental composition of an analyte by its electromagnetic or mass spectrum. Several analytical techniques are available:

  • Atomic absorption (AA): flame and graphite furnace
  • Inductively coupled plasma optical emis ...

NexION 1000/2000/5000 ICP-MS Consumables & Supplies Guide

Look to PerkinElmer for all of your consumables and supplies for your NexION 1000, 2000, or 5000 ICP-MS system.

NexION 5000 ICP-MS Preparing Your Lab

This document provides information to assist in preparing your laboratory for the PerkinElmer NexION® 5000 ICP-MS system prior to instrument delivery and installation.


Product Note

NexION 5000 Multi-Quadrupole ICP-MS

The NexION® 5000 is a multi-quadrupole-based ICP-MS instrument engineered to remove the most complex interferences, ideal for multi-element analysis applications requiring ultra-trace-level detection. Download this product note to discover all of its innovative features.

PDF 760 KB

Regulatory Compliance Certification

Product Certificate - Nexion 5000

Product Certificate for the Nexion 5000

PDF 137 KB

Technical Note

Advantages of a Novel Interface Design for NexION 5000 ICP-MS

The novel design of the second-generation Triple Cone Interface with patent-pending OmniRing was developed specifically for the NexION® 5000 multi-quadrupole ICP-MS with both sensitivity and stability in mind. It builds on the Triple Cone Interface geometry of the ...

Advantages of a Novel Plasma Generator for the NexION 1000/2000/5000 ICP-MS Systems

Unlike other ICP-MS systems on the market that utilize conventional 40-MHz or 27-MHz commercially available generators which are typically customized and modified to work with ICP-MS instruments, the NexION® 1000/2000/5000 ICP-MS systems feature a 34-MHz frequency free-running RF g ...

PDF 986 KB
All Matrix Solution System for NexION ICP-MS Platforms

PerkinElmer’s AMS system provides a number of benefits to simplify analysis of high-matrix samples with theNexION family of ICP-MS instruments. By introducing a flow of argon into the spray chamber neck, the aerosol stream is diluted,allowing for more efficient ionization, fewer matrix effects, a ...

Interferences in ICP-MS: Do we still have to worry about them?

Interferences will always occur in ICP-MS and need to be dealt with. However, the NexION® 5000 multi-quadrupole ICP-MS with quadrupole Universal Cell is able to effectively and reproducibly remove spectral interferences leading to improved accuracy, repeatability and reproducibilit ...

Novel Interference Removal Opportunities with the NexION 5000 ICP-MS

The NexION® 5000 ICP-MS, with multi-quadrupole technology and Universal Cell, is able to take full advantage of element reactivity with 100% pure gases by analyzing them as cluster ions at higher masses where no interferences reside, and the background is clean. The Universal Cell, ...

TotalQuant Analysis in NexION ICP Mass Spectrometers

TotalQuant, a software feature unique to PerkinElmer's NexION® ICP-MS systems, intelligently interprets the complete mass spectrum, providing semi-quantitative to quantitative results for all elements. TotalQuant and survey scan can provide supplementary and confirmatory information ab ...

Unlocking Carbon-13 with Single Particle ICP-MS: Feasibility Study for Microplastic Detection

Carbon is difficult to measure with ICP-MS because of its high ionization potential and its presence in both the argon used to generate the plasma (primarily in the form of CO2, as an impurity) and in reagents, including acids and water. As a result, extremely high backgrounds exist at ...




White Paper

The Determination of Metals in Non-Medical Face Masks

With the onset of the COVID-19 pandemic, the use of face masks by the general public has become a critical personal protective measure to minimize person-to-person transmission. While health care workers use medical or surgical masks, the general population uses non-medical, otherwise known as hy ...

PDF 683 KB