NexION 2000 B ICP Mass Spectrometer

In this work, we demonstrate that PerkinElmer's NexION® 2000 ICP-MS, with its unique RF generator and ion optics, coupled with the Syngistix™ Nano Application Software Module, can be used to accurately measure and characterize NP sizes of 10 nm and smaller, both alone and in a mixture of NPs of various sizes.

This work demonstrates a robust method using SP-ICP-MS technology to detect CeO2 NPs which were extracted from soil samples with tetrasodium pyrophosphate (TSPP). Over the past few decades, engineered nanoparticles (ENPs) have been increasingly used in many commercial products. As a result, more and more ENPs have been released into the environment, which raises concerns over their fate, toxicity and transport therein.

This work has demonstrated the ability of the NexION 2000 ICP-MS to analyze both natural and drinking water samples in Standard (i.e. non-cell) mode, in accordance with U.S. EPA Method 200.8. Accuracy has been demonstrated through the analysis of several reference materials and spike recoveries, with stability of at least nine hours. Method detection limits allow for trace-level determinations, while the ability to selectively suppress user-defined isotopes also allows the measurement of analyte levels usually only possible by ICP-OES or Flame AA. The NexION 2000 provides a comprehensive solution to the challenge of U.S. EPA Method 200.8 and other drinking and natural water analytical requirements across the globe.

Measuring the amount of metals in CNTs presents a challenge. High levels can be measured directly in the solid by several techniques, including XRF and TEM, while low-level analysis requires complete digestion of the sample prior to analysis by ICP-OES or ICP-MS.

Through the years, both industry and analytical instrumentation have advanced. With the development of new chemicals and processes, new pollutants may enter the environment. However, the capabilities of analytical instruments have also increased, allowing the measurement of ever lower levels of environmental contaminants, as well as new pollutants.

In the textile industry, the use of titanium dioxide (TiO2) nanoparticles (NPs) is increasing due to their ability to provide UV protection, increase the hydrophilic nature of fabrics, provide antibacterial characteristics, and reduce odors. This work studies the release of TiO2 NPs from various commercial textile products which do not advertise that TiO2 NPs have been added.

Eye drops are commonly used medications which are available both over-the-counter and as prescriptions in various forms. Because eye drops are classified as a parenteral medication and have relatively large daily doses, the inorganic components in eye drops must be present at low concentrations. As a result, ICP-MS is the most appropriate technique for the determination of trace elements in eye drops.

The International Conference on Harmonization Guideline for Elemental Impurities Q3D (ICH Q3D) has established maximum permitted daily exposure limits for elemental impurities in pharmaceutical products. This work discusses the sample preparation and analysis of Class 1, 2, and 3 elements in a variety of eye drops with the NexION ICP-MS, following the criteria defined in ICH Q3D. The developed methodology (both sample preparation and analytical) demonstrates both accuracy and stability.

This work demonstrates how Single Cell ICP-MS (SC-ICP-MS) can be used to monitor gold nanoparticle uptake by algae with PerkinElmer's NexION ICP-MS.

Cisplatin, carboplatin, and oxaliplatin are the most widely used of platinum-based cancer chemotherapy drugs in the Western world. Cisplatin's effectiveness is due to its ability to bind to the DNA, resulting in DNA-platinum (Pt) adducts, which bend the DNA. The cells must then repair the DNA damage, otherwise DNA replication is blocked resulting in cell death. Many cancers are initially sensitive to platinum-based treatment, but patients frequently relapse with tumors displaying resistance to further cisplatin therapy.

This work demonstrates the ability of PerkinElmer's NexION 2000 ICP-MS to perform accurate, stable analyses of blood and serum samples, leveraging the benefits of the Universal Cell and the ability to use three cell gases in a single method.

Owing to the toxicity of heavy metals, it is increasingly important to test cannabis flowers and other cannabis derivatives so that patient and consumer safety is maintained as the use of cannabis becomes more common. This need has translated into an increasing demand for testing cannabis flowers and other cannabis derivatives for toxins such as the heavy metals cadmium (Cd), lead (Pb), arsenic (As), and mercury (Hg). In this application note, we present data to illustrate the successful validation of the Titan MPS™ Microwave Sample Preparation System and the NexION® ICP-MS for the determination of heavy metals in cannabis flower according to the validation protocols set in USP General Chapter <233>, which are commonly used for evaluation of the levels of elemental impurities in samples.

Nanoparticles (NPs) have been of significant interest over the last two decades as they offer attractive benefits for drug delivery to overcome limitations in conventional chemotherapy. Nanoparticles can be engineered to carry both drugs and imaging probes to simultaneously detect and treat cancer. They may also be designed to specifically target diseased tissues and cells in the body. A number of nanoparticlebased cancer therapeutics have been approved for clinical use and/or are currently under development.

The United States Pharmacopeia (USP) has announced that its new standards for elemental impurities in drug products has been implemented since January 1, 2018. General Chapters <232> and <2232> specify the list of elements and their permissible daily exposure (PDE) limits based on the route of administration.

This work investigated the transfer of Ag and CuO nanoparticles from consumer products via simulated dermal contact by using textile wipes as a surrogate using PerkinElmer’s NexION ICP-MS single particle analyzer with the unique Syngistix Nano Application software module for data collection and analysis

Learn more about our various testing methods and applications for cannabis analyses by reading through our Cannabis Testing brochure.

PerkinElmer's NexION 2000 ICP-MS is the most versatile ICP-MS on the market, featuring an array of unique technologies that combine to deliver the highest performance no matter what your analytical challenge.

Oil refineries and natural gas producers around the world require their lab operations to perform large numbers of analyses before their products are used in industries and by consumers. Detection of even the slightest impurities, accurate process control and hydrocarbon distribution analysis is critical to the success of these operations.That’s how PerkinElmer can help. As a global scientific leader and solutions provider to refining and natural gas labs, PerkinElmer's proven technology and experience meets the ever-changing needs of the oil and gas industry. PerkinElmer is committed to the success of your oil and gas sample analysis by providing the instrumentation, software, consumables, and services you need for fast, easy and precise testing. The result: better control of your operations and improved product quality.

With instruments that are the industry standard worldwide, PerkinElmer accessories, consumables, methods and application support meet the most demanding requirements and are the preferred choice in thousands of laboratories globally.

This guide provides a basic overview of the most commonly used atomic spectroscopy techniques and provides the information necessary to help you select the one that best suits your specific needs and applications.

Look to PerkinElmer for all of your consumables and supplies for your NexION 1000 or 2000 ICP-MS system.

PerkinElmer ICP-MS instruments are complete systems with the exception of the following items which must be provided by the customer: electrical power, exhaust vents, argon gas supplies with approved regulator, cell gas supply with approved regulators

PerkinElmer’s Syngistix Enhanced Security software for AA, ICP and ICP-MS meets the special needs of highly regulated labs such as those that must comply with the U.S. FDA’s 21 CFR Part 11 regulations.

Product Certificate for the NexION 1000/2000

PerkinElmer's NexION 1000/2000’s patented RF generator combined with the novel design of the self-cooling LumiCoil RF coil provides a reliable plasma source for a wide range of demanding trace-element detection applications.

PerkinElmer’s All Matrix Solution system provides a number of benefits to simplify analysis of high-matrix samples with the NexION family of ICP-MS instruments.

Discover how the PerkinElmer Asperon Spray Chamber can deliver "intact individual cells" to ICP-MS Plasma.

Extractables and leachables studies are critical for maintaining the quality of your drug product and complying with GMP regulations during drug development and final batch release. Exposure to extractables and leachables could have a detrimental impact on the safety and efficacy of a final drug product. Testing for these contaminants is critical in every part of pharmaceutical packaging including the packaging system used to store drug products.