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QSight Triple Quad 400 Series

Ideal for analyzing food, cannabis, and environmental samples, our robust and reliable QSight® triple quad systems consistently deliver the throughput and productivity you need in your analytical testing lab. Now we’ve added the premier model to our QSight family: the high performance 400 series. This ready-to-implement solution has the highest sensitivity and throughput the industry has ever seen and the capability to test for the most challenging, complex samples, including cannabis.

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BC003844
QSight 400 Series
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BC003382
QSight 200 Series
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BC003264
QSight 100 Series
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Overview

Future proof your lab with the flagship QSight triple quad 400 series. This powerful LC/MS/MS system is engineered to deliver exponentially better sensitivity that commercial testing labs, global food manufacturers and exporters, and highly regulated cannabis labs need to meet their most stringent requirements – today and tomorrow.

  • Highest sensitivity to meet the most demanding regulations
  • Easy-to-use with ready to implement methods – just set and forget
  • Patented flow-based technology that enables up to 15% more productivity StayClean Source, self-cleaning design for maximum sensitivity and exceptional uptime
  • Laminar Flow Ion Guide for highly efficient field-free transmission, providing virtually no maintenance requirements
  • Dual Source technology gives you the capability to set ESI or APCI modes, with two independent probes for true multiplexing
  • Modular Simplicity 3Q software to acquire, quantify, and report with flexible data viewing options and powerful remote diagnostics.

Specifications

Model Name QSight 400 Series
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Application Note

"No Dilute” Just Shoot: Robustness of a QSight LC-ESI-MS/MS for Pesticide Residue Analysis in Wine

In this study, we used the QSight LC/MS/MS system to evaluate the potential of eliminating sample preparation for trace level pesticide analysis in a complex sample such as wine. We injected undiluted red and white wine samples into the mass spectrometer and studied reproducibility in analysis of the spiked pesticides over 200 injections. The instrument showed excellent reproducibility with minimal signal drift during the duration of the study (over a week), confirming the robustness of the QSight mass spectrometer.

PDF 962 KB
A Multiclass Multiresidue Method for Analysis of Veterinary Drugs in Chicken by UHPLC/MS/MS

Multiclass, multiresidue method for analysis of 73 veterinary drugs (covering 13 different chemical classes) in chicken samples by coupling solvent extraction method with LC/MS/MS. Better recoveries were obtained for all the analytes without sample clean-up when comparing with different sample cleanup methods. Due to the high sensitivity of QSight mass spectrometer and its unique StayClean technology (hot-surface induced desolvation (HSID) and Laminar Flow Ion Guide),20 sample extracts can be analyzed directly without timeconsuming solvent evaporation and analyte concentration steps.

PDF 1 MB
A New, Sensitive Method for Lignan Metabolite Detection of Flaxseed-Fed Mice Using LC/MS/MS

A New, Sensitive Method for Lignan Metabolite Detection of Flaxseed-Fed Mice Using LC/MS/MS

PDF 1 MB
A Simple and Sensitive Method for Rapid Determination of PFOA and PFOS in Water Samples by Direct Injection UHPLC/MS/MS

Per- and polyfluoroalkyl substances (PFASs), or Per- and polyfluorinated compounds (PFCs), represent a group of anthropogenic chemicals that have been produced and widely used in industrial applications and consumer products since the 1950s. The unique physical and chemical characteristics of these compounds (highly stable and resistant to degradation), along with their ubiquitous use, have led to the accumulation of PFAS in the environment, with growing concern of human exposure to these chemicals. The most widely used analytical method for PFAS monitoring is LC/MS/MS owing to its high sensitivity, selectivity and robustness. Recently, with the advancement and availability of highly sensitive mass spectrometers, a trend towards developing a high throughput analytical method for monitoring PFASs by direct injection without SPE has been appreciated. The direct injection approach can achieve higher levels of sample throughput, and reduce potential analyte loss and contamination caused by SPE sample preparation, as demonstrated by this study using PerkinElmer’s QSight® 420 mass spectrometer, coupled with UHPLC for the determination of trace amount of PFOA and PFOS in drinking and surface water samples.

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A Single Cannabis Method to Meet California Pesticide and Mycotoxin Residues Regulatory Requirements

Testing for the levels of pesticide and mycotoxins in cannabis is important to ensure consumer safety and quality control. In this work, the PerkinElmer application development team analyzed all 66 pesticides (including very hydrophobic and chlorinated pesticides typically analyzed by GC-MS/MS) and five mycotoxins spiked in cannabis flower extracts well below the action limits specified by the state of California. A LC-MS/MS instrument was used with ESI and APCI sources and a simple solvent extraction method with excellent recoveries for all analytes in acceptable range of 70-120%.

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Analysis of Acrylamide in Potato Chips

Acrylamide is an amide-type organic compound that can be formed by cooking or processing food at elevated temperatures . We have developed a rapid, sensitive and reproducible HPLC-MS/MS method for analysis of acrylamide in potato chips, using a simple sample preparation procedure. The LOQ is 25 µg/kg. The QSight mass spectrometer provides a robust platform for analysis of trace acrylamide levels in compilance with European Regulation. This method can also be applied to other types of regulated matrices such as bread, biscuits, breakfast cereals, and more.

PDF 1 MB
Analysis of Aflatoxins by UHPLC

This application note demonstrates the effective chromatographic separation of aflatoxins B1, B2, G1, G2 and M1 by UHPLC-MS/MS, achieving the 0.05-ppb control limit for M1 without the need for derivatization.

PDF 1 MB
Analysis of Challenging Polar Contaminants in Water by LC/MS/MS with Direct Injection

Several directives throughout the EU provide guidance on environmental quality standards for water, and define more than 30 priority substances as significant risk to humans. Many of the monitoring limits within these directives are set at low µg/L (ppb) levels, and as such, require highly sensitive methods and instrumentation.

In this study, various methods for the separation, detection and quantitation of complex polar contaminants by UHPLC/MS/MS are presented. Utilizing two columns and three separate analytical methods, metabolites such as trifluoracetic acid, the antidiabetic metformin, and various inorganic contaminants, such as chlorate and bromate are successfully and efficiently quantified.

PDF 1 MB
Analysis of Haloacetic Acids in Drinking Water

Haloacetic acids (HAAs) are a class of undesired by-products resulting from the reaction of chlorinated disinfectants with natural organic matter in water. The resulting substances are considered major disinfection by-products (DBP), which are known for being carcinogenic and also associated with reproductive problems in humans. The five major HAAs of particular concern include monochloroacetic acid (MCAA), monobromoacetic acid (MBAA), dichloroacetic acid (DCAA), dibromoacetic acid (DBAA) and trichloroacetic acid (TCAA). Haloacetic acids are regulated by the U.S. Environmental Protection Agency (EPA) government. In this application note, a reliable and fast method for determination and quantification of five HAAs in potable drinking water is presented using a PerkinElmer QSight® LX50 UHPLC system coupled to a PerkinElmer QSight 220 MS/MS detector. The five HAAs eluted within three minutes with excellent reproducibility.

PDF 1 MB
Analysis of Multi-Residue Pesticides in Rice by LC/MS/MS

Liquid chromatography tandem mass spectrometry (LC/MS/MS) has become the method of choice for pesticide analysis due to its high selectivity and sensitivity as well as its suitability for a wide range of compounds in various sample matrices. 0 In this study, a fast, sensitive and selective multi- residue method has been developed for analysis of over 200 pesticides in rice samples by coupling a modified QuEChERS extraction method with LC/MS/MS. Using time-managed- MRM in the QSight® triple quadrupole mass spectrometer, the optimum dwell time of multiple MRM transitions can be generated automatically for the targeted analytes. This not only saves time in method development but also improves data quality and analytical performance, as demonstrated in this study by the results of multi- residue pesticide analysis in rice samples.

PDF 1 MB
Analysis of Mycotoxins in Multi-Grain and Corn Cereals

An effective, reliable and robust LC-MS/MS method, using time-managed MRM (Multiple Reaction Monitoring) transitions, for the monitoring of mycotoxins in multi-grain and corn cereals at low µg/kg levels, without the need for derivatization. The analyzed mycotoxins included aflatoxins B1, B2, G1, G2, ochratoxin A, HT-2 and T-2 toxins, ergocristine and fumonisins F-B1 and F-B2.

PDF 991 KB
Analysis of Pesticide Residues in Cannabis Regulated by Oregon State Using LC/MS/MS

Liquid chromatography-tandem mass spectrometry (LC/MS/MS) has become the method of choice for pesticide The state of Oregon has issued regulatory limits for 59 pesticide residues in both cannabis flower and concentrates. In this study, all 59 pesticides were spiked into cannabis flower samples and analyzed by coupling QuEChERS sample preparation with LC/MS/MS. All the 59 pesticides in Oregon’s regulated list were detected using this methodology, with results well below the current action limits specified. Recoveries of pesticides from spiked cannabis flower extracts are shown to be between 70-120%.

PDF 1 MB
Analysis of Pork Adulterated Meat

A selective and sensitive LC/MS/MS method for fast identification and analysis of meat samples using three peptides specific for pork as biomarkers. . The optimized sample preparation procedure is easy to follow and can be used for analyzing raw, cooked and processed meat products. This method can selectively detect peptides from pork meat species at a threshold detection limit of 1% w/w (10 mg/g) in a variety of food products and thus the method can be useful for analysis of Halal food (or pork related food products) samples.

PDF 1 MB
Analysis of Target Pesticide Residues in Berries with LC/MS/MS Coupled with a QuEChERS Sample Prep

In the present study, a unique laminar flow UPLC-ESI-MS/MS triple quad mass spectrometer was used to identify and quantitate 40 pesticides in four brands of nonorganic berries. The QuEChERs extraction method proved both rapid and reliable for extracting pesticide residues in the heavily pigmented berry samples. These results obtained demonstrate this methods applicability and effectiveness in detecting and quantitating pesticides lower than 10 parts per billion (ppb), per regulatory limits set by the EU directive 91/414/EEC.

PDF 1 MB
Analysis of Water-Soluble Vitamins in Infant Formula by UHPLC-MS MS

Water-soluble vitamins (WSV), comprised primarily of the vitamin B complex, are essential ingredients in many foods, particularly in infant formulas. When analyzing fortified foods, this can be particularly challenging due to the wide range in concentration of vitamins, in keeping with daily allowances. This application note presents a LC-MS/MS method for the efficient, routine and robust chromatographic analysis of B-vitamins in infant formula. Eight water soluble vitamins over a wide concentration range were identified and quantified in under four minutes. The results showed excellent retention time repeatability and the method was able to detect vitamin B12 at 0.5 ppb, well below the expected level of ~2 ppb in infant formulas.

PDF 1 MB
Detection of Fipronil and its Metabolites in Eggs

A recent recall of contaminated eggs in Europe has generated a serious health concern for fipronil poisoning. Fipronil is a highly toxic insecticide and it is used to protect crops. The U.S. EPA has classified fipronil as a group C carcinogen. In this study, we describe a fast and robust analytical method for identifying fipronil and its metabolites with the PerkinElmer QSight® 200 series LC/MS/MS triple quadrupole instrument. The results demonstrate excellent recovery, linearity and reproducibility and superior sensitivity for this method. The three-step sample preparation procedure is quick and easy, and the LC/MS/MS analysis time can be carried out within six minutes with great separation for all analytes.

PDF 719 KB
Determination of Polycyclic Aromatic Hydrocarbons in Seafood by UHPLC- MS/MS

Polycyclic aromatic hydrocarbons (PAHs) can contaminate foods during smoking, heating, and drying processes that allow combustion products to come into direct contact with food. They can also enter food supply chains through contaminated air and water, and accumulate in various food chains. Regulations are in place to monitor PAHs levels in foods; the EU set a stringent maximum residue limit (MRL) for BaP in muscle meat of smoked fish and smoked fishery products at 2 µg/kg.2 In this study, seafood samples were prepared using a QueChERS extraction method followed by a dispersive solid-phase extraction clean-up step. The samples were subsequently analyzed by coupling a UHPLC system with a triple quadrupole mass spectrometer.

PDF 1 MB
Determination of Sulfonamides in Honey

In apiculture, sulfonamides are the most commonly used antibiotics to treat American and European Foulbrood, a type of disease that infects bees. This application note demonstrates how QSight 200 System can provides a very sensitive and robust platform for the analysis of sulfonamides in honey.

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Direct Analysis of Glyphosate and Similar Polar Pesticides in Oatmeal by UHPLC-MS/MS

Glyphosate (N-(phosphonomethyl) glycine), an organophosphorus compound, is used to kill weeds (e.g. annual broadleaf weeds and grasses) that compete with crops. Like other pesticides, glyphosate is directly administered to food products and can come in contact with both food workers and the environment, resulting in the bio burden of exposure in uncontrolled regional populations. Our study reports a 12 minute LC/MS/MS method with an amino-based column to analyze glyphosate and other related polar compounds in underivatized states, with exceptional selectivity and sensitivity.

PDF 1 MB
Efficient LC/MS/MS Method for Testing Hemp Samples for Pesticide Residues

Agricultural growing of hemp products for the purposes of cannabidiol (CBD) extraction was legalized in the United States with the passing of the Agricultural Improvement Act of 2018. Since the act passed, heightened concern over the use of pesticides in hemp production has been appreciated. However, no federal guidance is currently available in the United States to standardize analytical methods for the detection and quantification of pesticide residues in hemp products.In this application note, a robust and efficient single-run LC/MS/MS method for the determination of 66 pesticides, including hydrophobic and chlorinated pesticides typically analyzed by GC/MS/MS, is presented. Utilizing a PerkinElmer QSight® 420 UHPLC with MS/MS detector and dual ESI and APCI sources, excellent recoveries in the range of 70-120% were achieved. The application note also outlines participation in an Emerald Scientific blind proficiency test, with acceptable results for all 66 pesticides.

PDF 1 MB
High Sensitivity Analysis of Estrogens in Water and Urine by Direct Injection UHPLC/MS/MS

Estrogen plays an important role in the human body, but excess concentrations of endogenous estrogens, a known endocrine disrupting compound (EDC), in urine have been linked to the development and growth of breast cancer and tumors in females. Endogenous estrogens, including estrone (E1), 17ß-estradiol (E2), and estriol (E3), have also been detected in environmental matrices such as surface, waste and drinking water, even after extensive removal treatments. The accurate and efficient quantification of estrogen in both urine and water is paramount to ensuring the health of humans and animals in impacted ecosystems.

This application note details a method for the analysis of three endogenous estrogens at low ng/L (ppt) levels in both urine and water matrices. The method presented utilizes a PerkinElmer QSight® 420 triple quadrupole LC/MS/MS, and demonstrates good linearity, precision and accuracy, without the need for derivatization and concentration with SPE.

PDF 1 MB
Method Validation for Atrazine Analysis in Fresh, Atypical Mineral and Carbonated Waters

EU water policies are reevaluated on a consistent basis to ensure water sources do not contain contaminants at levels above regulatory levels. As regulations are reviewed, regulatory limits are often lowered, and analytical techniques must adapt to meet the new stringent requirements.

In this application note, an LC/MS/MS method for the determination of 214 regulated contaminants is presented. The direct injection method, utilizing a PerkinElmer® QSight 420, is optimized with the use of dual ionization sources (APCI and ESI). Additionally, an inter-laboratory study is detailed to illustrate the method transferability between instruments, utilizing the compound Atrazine.

PDF 1 MB
Pesticide Residues and Illegal Additives in Wine

Both pesticides and illegal additives, if present in significant levels in wine, can pose health risk to consumers. In this study, a simple and sensitive LC-MS/MS method has been developed and applied for the determination of both pesticides and pigments in a single analytical run.

PDF 1006 KB
Pesticide in Grapes by LC-MS/MS

Pesticide residue is a major concern for the stakeholders of the grape industry, due to more and more stringent regulations and safety standards in most countries. In this study, a fast, sensitive and selective multi-residue method has been developed by coupling QuEChERS sample preparation with LC-MS/MS. Using time-managed-MRM in the QSight triple quadrupole mass spectrometer, the optimum dwell time can be generated automatically for MRM transitions based on the number of co-eluting transitions, expected cycle time, retention time and tolerance time window of the targeted analytes. Such method automation results in improved data quality, better sensitivity, accuracy, and reproducibility, as demonstrated in this study by the results of 213 pesticide residues analyzed in grape samples.

PDF 1 MB
Polymer Applications Compendium

Today’s plastics are some of the most used materials on a global volume basis. Broadly integrated into today’s industrial and commercial lifestyles, they make a major, irreplaceable contribution to virtually every product category.

In this compendium you will find a wide range of applications for polymers, plastics, rubbers and advanced materials. Discover how to put these applications to work for you simply and efficiently.

PDF 57 MB
Rapid and Sensitive Analysis of 17 Per-and Polyfluoroalkyl Substances in Water by Direct Injection with QSight 420

Per- and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic organic compounds which have been utilized as aqueous film forming foams (AFFF) for firefighting purposes, and as stain and water resistant coatings on a number of consumer products such as clothing, furniture or cookware. PFAS compounds are highly stable from a chemical and physical standpoint, and their resistance to degradation in the environment has led to concerns over accumulating levels of PFAS in environmental habitats.

In this application note, a versatile and efficient direct inject approach to the analysis of 17 PFAS compounds in drinking and surface water samples utilizing a PerkinElmer QSight® 420 LC/MS/MS is presented. The method offers improved sample throughput, while reducing the potential of analyte loss and contamination that can result from SPE sample preparation.

PDF 3 MB
Simultaneous Detection of Estrogenic and Progestogenic Hormones in Edible Bird's Nest

This application note presents a sensitive and reliable LC/MS/MS method using the PerkinElmer QSight

PDF 859 KB
Simultaneous Determination of Plant Growth Regulators in Bean Sprouts

A simple and sensitive method for the simultaneous determination of plant growth regulators

PDF 2 MB

Brochure

Cannabis Testing Solutions Brochure

Learn more about our various testing methods and applications for cannabis analyses by reading through our Cannabis Testing brochure.

PDF 9 MB
Grain Testing Solutions Brochure

The grain industry is very complex. It’s global, diverse, and can also present analytical challenges. Today’s grain users demand more when it comes to quality, safety, and uniformity. In addition, they seek diverse products with unique characteristics.

PerkinElmer is equipped to help the grain industry in its quest to feed the world – nutritiously and economically. Our testing and analysis solutions encompass the three primary areas required for complete knowledge of grains and their derivatives – composition, functionality, and safety.

PDF 6 MB
QSight Pesticides Analyzer Brochure

Pesticides can adversely affect human health through the food we consume but can also leach into soil and groundwater and impact us through the environment. To keep up with a complex and constantly changing regulatory environment, your pesticide analysis solution needs to keep up with your burgeoning sample load.

PDF 9 MB
QSight Triple Quad LCMSMS 400 Series Interactive Brochure

Our QSight triple quad LC/MS/MS family has always been known for its robust and reliable performance. But now there’s something new – something better: the high performance 400 series. Our ready-to-implement solution has the highest sensitivity and throughput the industry has ever seen and the capability to test for the most challenging samples and analytes.

PDF 6 MB
QSight Triple Quadrupole LC/MS/MS

Whether you’re a lab manager or a bench chemist, you know firsthand how things are changing quickly in food and environmental analysis. And your lab needs to change to keep pace.

PDF 8 MB

Poster

Advanced Solutions for Polymers and Plastics Poster

The Polymer Market consists of a huge diversity of manufacturers of industrial products running many different processes yet still facing similar challenges. There is more and more pressure to achieve high product quality and reduce costs in order to stay one step ahead of the competition.

PDF 3 MB

Product Note

PDF 890 KB
QSight Simplicity 3Q Software Suite

Our modular Simplicity 3Q™ software is ideal for acquiring, quantifying and reporting

PDF 1 MB
QSight Triple Quadrupole LC/MS/MS Preparing Your Lab

Lab reequirements for QSight triple quad LC/MS/MS systems, including storage, suppleis, space, electrical, power, gas supply requirements

PDF 660 KB

Technical Note

Flow Characteristics of a Laminar Flow Interface for LC/MS/MS

Simulation using sophisticated modeling techniques has become a powerful tool for mass spectrometry

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Ion Transmission Through a Quadrupole Ion Guide

Ion Transmission Through a Quadrupole Ion Guide Under the Combined Influence of Viscous Flow and RF

PDF 1 MB
Theoretical Studies of Swirling Flow and Heating Methods

Theoretical Studies of Swirling Flow and Heating Methods on Droplet Evaporation in a Heated Coaxial

PDF 503 KB