Designed for fast-paced, high-volume laboratories that need to increase analytical cycle times, the Clarus 690 GC provides superior sensitivity, capacity, and throughput – with flexibility to handle more. Our industry-leading portfolio of TurboMatrix™ options include headspace (HS), manual and automated thermal desorption (TD, ATD) and MultiPrep Autosampler solutions.
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When the highest levels of throughput are critical to your operations, choose the Clarus 690 gas chromatograph. Its patented high-performance oven delivers the fastest heat-up and cool-down of any oven in the business, and that means shorter injection-to-injection times, and the ability to run more samples per day. Plus, the oven’s twin-wall design with concentric air exhaust provides exceptional cooling to near-ambient temperatures without resorting to liquid cryogen – critical for analysis of VOCs. The Clarus 690 GC features a wide-range flame ionization detector (FID), a new high-performance capillary injector with decreased reactivity, and autosampler technology that delivers multiple options for liquid injection, headspace, and SPME on one system.
This system is driven by our TotalChrom™ chromatography data system (CDS) that serves as both an instrument controller and a data management system, making it the best choice for data handling in demanding multiuser, multisite environments where a number of instruments are in use. Plus, the TotalChrom system’s unique data protection features ensure that data acquisition processes aren’t disrupted or compromised. Plus, our GC instruments feature an intuitive touch-screen interface with real-time signal display and eight-language support for greatly simplified user interaction.
The calibration/Internal standards are available but must be ordered separately.
The purpose of this app note is to apply novel oven technology, a short GC column and high oven heating and cooling rates to a modified 8015 DRO method.
At the height of the first wave of the COVID-19 pandemic, consumers around the world experienced a supply shortage related to alcohol-based hand sanitizer. As new producers entered the market, and existing manufacturers sought to ramp-up production to meet the growing demand, lower grades of ethanol and isopropanol (IPA) started to appear on the market. To ensure the safety and efficacy of hand sanitizer products, it is recommended that manufacturers test their products to ensure appropriate levels of active ingredients, as well as a means of ensuring label-claim accuracy. This application note outlines a fast, robust and accurate GC-FID solution for the quantification of ethanol and IPA in hand sanitizers for label claim purposes.
Microplastics are a major concern due to their impact on the environment. There is growing research into microplastics, typically submillimeter in size, and which often end up in waterways and oceans. They remain in a suspended state and can be ingested by marine organisms; thereby entering and accumulating within the food chain. Hyphenated thermogravimetric analysis (TGA) and gas chromatography mass spectrometry (GC/MS), referred to as TG-GC/MS, enables in-depth characterization of evolved gases through real-time analysis of the products resulting from the thermal decomposition of the suspended microplastic matter. This results in greater information on the identify of the degradation products as well as details on when the degradation products are formed.
This application note describes a powerful analytical technique to measure constituents of microplastics using a hyphenated TG-GC/MS system.
Solvent such as supercritical CO2, butane, propane, other hydrocarbons, water, or alcohol are used to extract out the cannabinoids and terpenes from the plant material. In some cases, the solvent and impurities from the solvent remain in the extracted material. This study will shows the analysis of residual solvents using pressure-balanced headspace (HS) sample introduction coupled with Gas Chromatography/Mass Spectrometry (GC/MS). Unambiguous separation of all compounds is obtained while maximizing sample throughput.
Trimethylamine (TMA) is a volatile organic compound known to be a major contributor to malodor pollution. Created in a gaseous form as a result of the manufacture, use and disposal of materials utilized in sewage treatment plants, the low odor threshold of TMA results in regular poor air quality complaints of residents living near treatment plants.
In this application note, a method for the analysis of TMA in the exhaust gas of a station pollution source is presented. Utilizing a PerkinElmer TurboMatrix™ HS-40 sampler and a Clarus® GC with nitrogen phosphorus detector (NPD), TMA is detected with MDLs well below the standards developed by US and Chinese regulatory bodies.
Optimized methods are needed for the analysis of toxic compounds in air to understand the impact to human health. People breathe approximately 20,000 liters of air a day so this concern is significant. EPA Method TO-17 is used to determine toxic compounds in air after they have been collected onto sorbent tubes. This application note demonstrates that the PerkinElmer TurboMatrix™ Thermal Desorber and the PerkinElmer Clarus® SQ 8 GC/MS will meet and exceed the criteria set forth in EPA method TO-17. Detailed instrument method parameters are presented, with precision, recovery, linearity and detection limit results.
The European Union directives assist the member states to define the activities to be programmed and the objectives to be achieved. In this framework, the chemical analysis of the water system is the main activity to preserve the healthiness of the waterways through monitoring and detection of substances that are harmful to the environment and to the health of citizens.
This application shows this framework could be achieved with GC/MS analysis.
Although considered pharmacologically inert, pharmaceutical excipients have been shown to interact with active drug substances to affect the safety and efficacy of drug products.Therefore, there is an increasing awareness of the necessity to understanding interactions between excipients and the active pharmaceutical ingredient (API) in finished dosage forms.
Global demand is increasing for environmentally friendly waste treatment options for used mineral oils such as motor oil, lubricants, insulating liquids and hydraulic oils. New waste treatment options allow for the recycling of used oils into new useful raw materials, thus reducing carbon emissions and contributing to a cleaner environment. During the recycling process, contaminants, such as ethylene glycol, are removed from the used oil and a clean base oil is produced which can later be used in the production of new lubricant oils or can be mixed with freshly refined base oils.
In this application note, a simple and effective method for the extraction and analysis of ethylene glycol in a used oil sample is presented. Utilizing a solvent extraction method, followed by analysis utilizing a Clarus® GC with FID detector, the cost of the analysis can be significantly reduced, while maintaining method efficiency and data quality.
Furan is naturally occurring at low levels in many foods and drinks. Furan consumption is of concern because it been classified by IARC as possibly carcinogenic to humans, based on studies in laboratory animals.
Malodor pollution in water has emerged as an increasingly worrisome consequence of continued worldwide urbanization and industrialization. Volatile organic sulfur compounds (VOSCs), such as dimethyl disulfide (DMDS) and dimethyl trisulfide (DMTS), have been identified as a primary contributor to malodor pollution in water, and are considered a serious safety and environmental threat, rendering drinking water sources unpalatable. In this study, a method for the determination of DMDS and DMTS in water was established using a PerkinElmer Clarus® GC/FPD with the TurboMatrix™ HS-40 Trap. The methodology offers a simple, sensitive and efficient means of detecting DMDS and DMTS in water.
The existing ASTM® D4815 method is designed to monitor oxygenated compounds in gasoline at percentage concentrations. The method described in this application note is intended to enable these analytes to be monitored down to low-ppm concentrations.
Ethanol is often utilized in commercial denatured fuel products to improve performance, and does not exhibit many of the environmentally dangerous characteristics of tetraethyl lead (TEL) and methyl-tert-butyl ether (MTBE). The primary ingredient of denatured fuel is ethanol, with a small amount of methanol also utilized in the product. Producers of denatured fuel often face a unique analytical challenge when performing compositional quality checks on their products, as they must quantify both ethanol at nearly 100% of the weight of the product, as well as methanol at approximately 0.1 to 0.6 wt%.
To mitigate this challenge, PerkinElmer’s Clarus® GC systems’ wide-range flame ionization detector (FID) measures hydrocarbon compounds at very low and very high levels. In this study, a method for the determination of both ethanol and methanol in denatured fuel is presented.
ASTM® D7059-04 is an established method that has been well validated for the determination of methanol in crude oils. In this application note, a method based on a PerkinElmer® Clarus® 600 GC with an S-Swafer™ splitting device is described.
A common QC test in plastic production is the analysis of residual monomers in the final polymer material. This analysis is well suited for headspace sampling because headspace eliminates the sample preparation. The sample is analyzed directly with no need to dissolve the polymer.
Multiple headspace extraction (MHE) is a technique to exhaustively extract a sample and calculate the amount of analyte by comparison to an external standard. This application note will discuss the testing of polymers for residual monomers by MHE-GC/MS. The polymers tested in this application are used for the manufacturing of corrective eyeglass lenses. This material is monitored for acrylic acids, such as methylmethacrylic acid methyl ester (MMA).
Thymopentin (TP5), a 5-amino-acid polypeptide, is a safe and effective immunostimulant utilized in the treatment of a variety of immune disorders. Several residual solvents are used in the manufacture of TP5, including the "universal solvent" N,N-dimethylformamide (DMF), known for its high solubility to a variety of organic compounds. United States Pharmacopoeia has established an 880 ppm maximum concentration level for DMF to reduce potentially negative influences on the human body. This application note describes a GC/FID method for the determination of DMF utilizing a PerkinElmer Clarus® 680 GC/FID with TurboMatrix™ HS-40. The method offers a simple, sensitive and efficient means of detecting DMF with good linearity, repeatability and low reporting limits.
Volatile organic compounds (VOCs) are a series of compounds with high vapor pressure and boiling points from 50 to 250 degrees centigrade. These characteristics lead to the tendency for large numbers of molecules to evaporate, or volatilize, from their solid state into the air. VOCs are present in the environment from a number of sources, both anthropogenic and naturally occurring. In soil, VOCs are mainly derived from discharged industrial and domestic sewage, oil spills, and chemical solvent leakages. Monitoring of VOC contamination in soils by both qualitative and quantitative analyses is important to ensure that the potential negative health impacts of VOC exposure are mitigated. In this study, thirty seven VOCs are investigated in a soil matrix, using a PerkinElmer Clarus® GC/FID and TurboMatrix™ HS-40. Detailed instrument method parameters are presented with precision, linearity and reporting limit results.
As an alternative to tetraethyl lead, t-Butyl methyl ether (MTBE) has been widely used as an octane enhancer for gasoline. Studies have found increasingly high levels of MTBE in groundwater, often a result of accidental spills or leaking underground storage tanks. In this paper, a method for the determination of MTBE in water and soil was established using the PerkinElmer Clarus® 690 GC/FID with the TurboMatrix™ HS-40 Trap.
To meet the demands of complex petrochemical testing, our new Clarus® 590 and 690 gas chromatography (GC) instruments are preconfigured to provide a turnkey solution for a wide range of applications, including Simulated Distillation. We deliver a complete, ready-to-go system for faster, more efficient analysis in compliance with ASTM methods. Discover how the Clarus GC instruments enable the superior sensitivity and throughput you need for your most critical applications – plus the versatility to handle more.
The contamination of aviation fuel with fatty acid methyl esters (FAMEs) can arise due to the use of multi-product pipelines for fuel supply and distribution. This application note demonstrates the use of the Clarus 600 GC/MS to identify and determine the contamination.
Need to ensure quality, safety and reliability of food packaging? This compendium of Application Notes will provide you with R&D and QA/QC insights from plastic food trays, to bags, films and canned goods. The compendium provides research data and experimental results for; mechanical durability testing, analyzing multi-layer flexible laminates, studying extractables and leachables such as epoxyphenal-based coating, and other volatile organic compounds.
The rapid development of natural ,gas from unconventional sources in ,North America has created an energy ,“gold rush” not seen in contemporary ,times. The advent of horizontal drilling ,technologies and hydraulic fracturing has ,made this production economical and ,presents an energy source of sufficient ,magnitude that could last 100 years.
Beer is one of the most commonly consumed alcoholic beverages, and thorough and robust analysis of the raw materials used in the brewing process, as well as the finished product, is paramount to ensure consistent product quality and taste. There are a number of potential by-products and spillover products of the beer fermentation process which can potentially negatively impact the beer’s flavors, including vicinal diketone (VDK) compounds 2,3-butanedione (diacetyl) and 2,3-pentanedione, as well as acetaldehyde. Historically, breweries use two separate GCs, or two separate analytical runs in the testing of beers - one for the analysis of VDKs, and another for the analysis of acetaldehyde, which is potentially cost-prohibitive to many breweries. In this application note, an optimized method for the simultaneous analysis of VDK and acetaldehyde in beer in presented, using a PerkinElmer Clarus® 690 GC ECD/FID with a TurboMatrix™ HS-40.
This Application Note talks about pesticide residues analysis tested by Clarus 690 Gas Chromatograph
Residual solvents are used in the manufacture of active pharmaceutical ingredients (APIs), excipients, or in preparation of drug products, and are not removed during the purification processes. Residual solvents are one of the three main impurities in pharmaceutical materials; the other two are organic and inorganic impurities. Residual solvents do not provide any therapeutic benefit and should be removed to the extent possible, fulfilling quality-based requirements as per International Conference on Harmonization (ICH) guidelines – this is one of the standards to control the quality and the purity of the pharmaceutical substances, excipients, or drug products.
This paper will demonstrate the analysis of all three classes of residual solvents by pressure-balanced headspace sample introduction and GC-FID analysis. In addition to a discussion of the instrumental technique, the choice of the diluent will also be studied; two diluents will be used throughout.
Residual solvents are used in the manufacture of active pharmaceutical ingredients (APIs), excipients, or in preparation of drug products and are not removed during the purification processes. Residual solvents are one of the three main impurities in pharmaceutical materials.
Residual solvents do not provide any therapeutic benefit and should be removed to the extent possible, fulfilling quality based requirements as per International Conference on Harmonization (ICH) guidelines – this is one of the standards to control the quality and the purity of the pharmaceutical substances, excipients, or drug products.
This paper will demonstrate the analysis of all three classes of residual solvents by pressure-balanced headspace sample introduction and GC-FID analysis.
Although considered pharmacologically inert, pharmaceutical excipients have been shown to interact with active drug substances to affect the safety and efficacy of drug products. One of the areas of major concern is the potential chemical interaction between impurities in the excipient and the drug molecules, leading to the formation of reaction products. Formaldehyde present in excipients has been implicated in the degradation of several drug products where it can form adducts with primary and/or secondary amine groups. It has also been reported that formaldehyde can induce cross-linking in gelatin capsules causing an adverse effect on in-vitro dissolution rates of drugs.
This application note presents a simple and effective method for the determination of formaldehyde in pharmaceutical excipients using SHS-GC/MS. The method is fast, reliable and can be used for the quantification of low-molecular-weight aldehydes in most excipients commonly used in pharmaceutical products.
The use of Food Contact Materials (FCM) can potentially be detrimental to human health. In the PerkinElmer quantification of Phthalate Leaching from FCMs, using the Clarus GC/MS, we explore how to quantify FCMs.
Bioethanol, as defined by the U.S. Department of Energy, is a renewable fuel made from biomasses. It has widespread use in producing gasohol, a blend of alcohol and gasoline, which is utilized as an alternative fuel for cars and other vehicles in various countries. As part of Thailand’s effort in fighting pollution and climate change, there is a gradual national effort to shift the usage of gasoline to gasohol. Volatile congeners, such as C3-C5 mono-alcohols, are undesirable production by-products that can be present within the biofuel. To safeguard consumer confidence, the Thai government has developed regulatory guidelines to ensure the composition and quality of ethanol fuel products. In this application note, a method utilizing a PerkinElmer Clarus® 590 GC/FID for the analysis of samples in support of the Thailand Industrial Standard is presented.
Ethylene oxide (EO) is a highly reactive, toxic and flammable gas which can act as an irritant to humans at room temperature. Since the 1950s, EO has been utilized for the sterilization of medical instruments that cannot be exposed to moisture or high temperatures, including those made of polymers, plastics or those containing electronic components. Although the EO method ensures medical instruments can be sterilized without the deleterious effects of high-temperature sterilization, potentially dangerous side effects are possible, namely owing to the hazardous nature of the chemical.
In this application note, a rapid analytical method for the determination of EO in medical supplies was established using a PerkinElmer Clarus® GC/FID with the TurboMatrix™ HS-40. Empower® software was utilized throughout the entire experiment. This method demonstrates results with high efficiency, good linearity, sensitivity and repeatability for EO analysis.
The synthesis of active pharmaceutical ingredients(API) may require multiple reaction steps that produce undesirable reaction byproducts or utilize various solvents that have to be removed from the finished product. These solvents and byproducts may be measured with headspace gas chromatography for those volatile residual organic solvents according to the USP chapter 467 method.
This application note describes a method that is based on the original ASTM® D-3606 method with the main difference being that capillary columns are used. This approach completely eliminated all chromatographic interference from the ethanol (even solutions made up in pure ethanol could be run), improved the quality of the chromatography in general and reduced the analysis time significantly (by 50% or 75% depending on the column set).
The determination of light hydrocarbons in refinery and other gases is typically performed through the use of packed columns and mechanical rotary valves. For example ASTM Method D-2597 adopts this approach. A gas sampling valve delivers a small metered quantity of the sample gas into a non-polar packed column. The C1 to C5 hydrocarbons are allowed to elute from this column and into a second packed column with a polar stationary phase. At that point a rotary valve is actuated to reverse the flow of carrier gas through the precolumn and backflush any residual sample in that column to a detector to determine the total C6+ content in the sample. In the meantime, chromatography of the C1 to C5 content proceeds on the second column for separation, identification and quantification. The whole analysis takes about 20 minutes and getting acceptable chromatographic separation is often a challenge because of normal variations in the columns. In this application note, a new method is described for this analysis that uses a Swafer™ backflushing technology with capillary columns under isothermal conditions to both improve the chromatographic separation and to reduce the analysis cycle time to just over 5 minutes.
ASTM® Test Method, D2427-06, is designed to determine the C2 to C5 hydrocarbon content in gasolines. This method validates gasoline samples that are depentanized using ASTM® method D2001-07. These samples are intended for functional group hydrocarbon analysis by mass spectrometry according ASTM® Test Method D2789-95 (2005).
In today’s budget-constrained, yet highly competitive laboratory environments, the samples you’re being asked to analyze - whether food, pharmaceutical, petrochemical, or environmental - are increasingly difficult. But for some labs, having a dedicated GC for every application isn’t an option. For them, a GC that can do it all isn’t just a nice-to have, it’s a necessity.
Feed milling today is a complex business, and agribusinesses both large and small need to balance the nutritional and safety needs of livestock with availability of raw ingredients and their seasonality and variability. Add to that the valuable supplementation and medication that millers supply, and it’s clear: you’re creating a complete nutritional delivery system, not just a simple mix of grains.
The Deepwater Horizon oil spill has contaminated parts of the Gulf of Mexico and estuaries in several coastal states in the southern region of the US.
Innovation is the lifeblood of industrial polymer development – the push to improve materials or develop new ones infuses new life into the industry from R&D through to QA/QC. Manufacturers are continually challenged to ensure effective quality control and streamline processes while meeting stringent standards. Increasingly they must design for recycling and/or reuse in an ever more waste-adverse economy, keep a watchful eye on costs and stay ahead of the competition.
In response, we've gained years of experience developing a range of analytical capabilities to address a wide range of polymer analysis needs.
Download the interactive brochure to learn more about the most common challenges and our solutions in the market.
Increasing demands for efficiency, productivity, data quality, and profitability pose ongoing challenges for lubricant testing labs, like yours. Whether you need to achieve quick turnaround times, minimize downtime, or maximize lab efficiencies, you can rely on PerkinElmer for a comprehensive set of simple-to-use and proven testing solutions to help you achieve accurate results in record time. Learn more about our solutions.
Food testing labs like yours are constantly challenged with accurately analyzing samples quickly and efficiently - all while striving to reduce costs due to market forces. Your commitment to ensuring meat and seafood are safe for consumption, as demand increases, is an uphill battle.
Our commitment to you: to provide a range of solutions across multiple technologies, products, and services that meets or exceeds the testing needs of food processors. Our solutions offer more efficiency and increased accuracy and sensitivity for better yields in real time with minimal training.
From instrumentation and software to consumables and reagents to service and support, we are dedicated to providing you with end-to-end solutions that ease your everyday challenges of automation, throughput, service, and time to results.
Oil refineries and natural gas producers around the world require their lab operations to perform large numbers of analyses before their products are used in industries and by consumers. Detection of even the slightest impurities, accurate process control and hydrocarbon distribution analysis is critical to the success of these operations.That’s how PerkinElmer can help. As a global scientific leader and solutions provider to refining and natural gas labs, PerkinElmer's proven technology and experience meets the ever-changing needs of the oil and gas industry. PerkinElmer is committed to the success of your oil and gas sample analysis by providing the instrumentation, software, consumables, and services you need for fast, easy and precise testing. The result: better control of your operations and improved product quality.
Headspace gas chromatography offers an efficient sample-preparation technique that can save both time and money in the analysis of VOCs in a number of matrices. Headspace sampling is a separation technique which allows for the extraction of headspace vapor from a sealed sample, with subsequent injection directly into a GC. The technique obviates the need for time consuming and expensive solvent extractions, while also reducing the potential for human error in sample extraction.
PerkinElmer's TurboMatrix™ Headspace (HS) and Headspace Trap samplers utilize an array of proven technologies to ensure they deliver outstanding precision in any application. Learn more about PerkinElmer's HS solutions for up to 110 vials by downloading this brochure.
Today’s advanced and increasingly diverse chromatography laboratories are facing new challenges on a daily basis – starting from raw materials right up to the finished product. Our comprehensive portfolio of analytical solutions is designed to give you the higher accuracy, sensitivity, and ease of use your laboratory demands for examining with confidence, the purity, composition, and performance of your compounds. What’s more, a range of complementary services is available to keep your laboratory up and running, meeting the stringent requirements of a variety of environments and working practices.
Trust the consumables engineered for your instruments.
Quality control-monitoring and testing are important in ensuring the quality of palm oil. The quality control parameters are used to judge the quality of palm oil products and it can be monitored and tested to ensure that the palm oil is not deliberately or accidentally adulterated.
This report shows an example of three general degradation processes. The analytical system consisted of a Clarus GC/MS interfaced with a Pyrolysis Autosampler. Samples are rapidly pyrolyzed, automatically introduced into the GC carrier stream
Whatever your separation challenge, your choice of liquid chromatography (LC) column can make all the difference. Our Quasar portfolio of LC columns combined with the improved work? Workflow and usability of the LC 300 system allows you to achieve rugged and reproducible results. Now, with the purchase of an LC 300 system, you can pick out a Quasar LC column free of charge. Learn more below.
Increasing demands for efficiency, productivity, data quality, and profitability pose ongoing challenges for lubricant testing laboratories, like yours, performing new lubricant or in-service oil analyses.
Whether you need to achieve quick turnaround times, minimize downtime, or maximize lab efficiencies, you can rely on PerkinElmer as a trusted partner for simple-to-use and reliable testing solutions.
Partnering with leading global standards organizations and hundreds of oil laboratories, we continually address laboratory needs and ever-changing standards while developing new methods and protocols that conform with ASTM®, regulatory, and customer-defined requirements.
Download this infographic to learn more about our broad range of proven lubricant testing solutions.
The needs for polymer, pharmaceutical, chemicals, food and beverage, and environmental analyses are constantly changing due to innovation demands and regulation changes.
Evolved Gas Analysis (EGA) solutions combine multiple analytical technologies to empower speed and advanced information acquisition. Coupling Thermogravimetric Analyzer (TGA) systems with other analytical systems such as Gas Chromatography Mass Spectrometry (GC/MS) and Fourier Transform Infrared (FT-IR) Spectroscopy represents the most complete and advanced EGA solutions for gaining insights beyond decomposition of materials, by carrying out in-depth characterization of the evolved gases.
This comprehensive technology guide is your guide to understanding how hyphenation provides the insights - not just WHEN something has happened, but also WHAT happened.
Poster summarizing solutions of thermal analysis, molecular spectroscopy, chromatography and hyphenated techniques for polymers focused on providing more insight into product performance and process optimization that make easier
The Polymer Market consists of a huge diversity of manufacturers of industrial products running many different processes yet still facing similar challenges. There is more and more pressure to achieve high product quality and reduce costs in order to stay one step ahead of the competition.
With the new TurboMatrix MultiPrep+ and TurboMatrix MultiPrep autosamplers, PerkinElmer offers more choices than ever before to help you optimize the workflow of your gas chromatography instrument and maximize the throughput of your lab.
Based on EPA modeling, Method EPA 325 A/B will lead to a reduction of an estimated 52,000 tons per year of volatile organic compounds being emitted into the environment. In the face of this major new environmental standard, we can all breathe a bit easier knowing that PerkinElmer’s innovative technologies, operational effectiveness, and environmental expertise is available to help you become compliant.
This white paper discusses the role of System Suitability Tests (SSTs) in the context of Analytical Instrument Qualification (AIQ) and is based upon; the United States Pharmacopoeia (USP) general chapter 1058 on AIQ.