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Analysis of USP Grade Isopropyl Alcohol Impurities

Application Note

Analysis of United States Pharmacopeia (USP) Grade Isopropyl Alcohol Impurities

Analysis of USP Grade Isopropyl Alcohol Impurities

Introduction

Isopropyl alcohol, also known as Isopropanol or IPA, is commonly used as a sanitizer especially on skin surfaces such as prior to an injection of a vaccine or medicine. It is imperative this solution does not contain any impurities that are known to be a health hazard thus, the requirement for quality testing. The USP has published specifications for the maximum levels of known IPA targeted impurities including ethyl ether, acetone, diisopropyl ether, 1-propanol, and 2-butanol at 0.1% or less.

This analysis is explored with gas chromatography (GC) in two parts; the USP recommend conditions producing a 42-minute analysis time and a speed optimized method for rapid, accurate and precise result in less than 6 minutes.