Ideal for analyzing food, cannabis, and environmental samples, our robust and reliable QSight® triple quad systems consistently deliver the throughput and productivity you need in your analytical testing lab. Now we’ve added the premier model to our QSight family: the high performance 400 series. This ready-to-implement solution has the highest sensitivity and throughput the industry has ever seen and the capability to test for the most challenging, complex samples, including cannabis.
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This workhorse system provides exceptional sensitivity for difficult matrices in commercial testing labs and the food, environmental, and cannabis industries – it’s the perfect instrument for labs that need uncompromising performance.
Achieve the highest levels of performance from sample handling right through results and reporting with QSight triple quad LC/MS/MS systems.
|Model Name||QSight 200 Series|
QSight LC/MS/MS evaluates eliminating sample preparation for trace level pesticide in wine
Mycotoxins are toxic secondary metabolites produced by various fungal species growing in foods and animal feeds. To minimize risk and protect consumers, mycotoxin levels in foods and/or feeds have been regulated by agencies in many countries around the world. A number of analytical methods for the determination of mycotoxins have been utilized in the past, however LC/MS/MS method has become the method of choice for quantification and confirmation of mycotoxins in various food sample matrices owing to its superior sensitivity, selectivity and capability of analyzing multiple target mycotoxins in a single run.
In this application note, a method for the analysis of 12 mycotoxins in a number of common food matrices (yellow corn, white corn, wheat, soybean, almond, oat breakfast cereal, and peanut butter) utilizing a QSight 220 LC/MS is presented. A stable isotope dilution assay (SIDA) technique is used, which has been proven to be the most effective and preferred calibration approach for mycotoxin analysis in complex sample matrices because it can not only compensate for sample matrix effects, but also minimize variations in analytical procedures.
Veterinary drugs are used in animal production to treat diseases, prevent infection and protect growth of animals, which helps provide quality marketplace. However the uncontrolled use may cause heavy human disease so regulatory agencies around the world have established maximum residue levels (MRLs) or tolerances of veterinary drugs in foods. Drug analysis is generally challenging, due to the complexity of sample matrices and diversity of analytes from various classes of chemical properties. In this study, a fast, sensitive and selective method has been developed for analysis of 73 veterinary drugs (covering 13 different chemical classes) in chicken samples by coupling solvent extraction method with LC/MS/MS.
A New, Sensitive Method for Lignan Metabolite Detection of Flaxseed-Fed Mice Using LC/MS/MS
Testing for the levels of pesticide and mycotoxins in cannabis is important to ensure consumer safety and quality control. In this work, the PerkinElmer application development team analyzed all 66 pesticides (including very hydrophobic and chlorinated pesticides typically analyzed by GC-MS/MS) and five mycotoxins spiked in cannabis flower extracts well below the action limits specified by the state of California. A LC-MS/MS instrument was used with ESI and APCI sources and a simple solvent extraction method with excellent recoveries for all analytes in acceptable range of 70-120%.
Aflatoxin B1 is considered to be the most genotoxic of the mycotoxins, and, when ingested by cows, is converted to aflatoxin M1 which has been shown to cause liver cancer in certain animals.
Benzo[a]pyrene (B[a]P) is a well-known carcinogenic compound found in tobacco products and tobacco smoke. The Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) has recommended a gas chromatography/ mass spectrometry (GC/MS) method to determine concentrations of B[a]P in tobacco products. In the proposed method, B[a]P is extracted from the tobacco with methanol, followed by a solid phase extraction (SPE) and subsequent concentration prior to GC/MS analysis. The CORESTA recommended method is time-consuming, especially in sample preparation procedures, and showed low sensitivity. In this application note, a simple, reliable and fast analytical method for the determination and quantification of B[a]P in tobacco products has been developed using a PerkinElmer QSight® LX50 UHPLC system, coupled to a PerkinElmer QSight 220 MS/MS detector.
Mycotoxins produced by fungi as toxic secondary metabolites, leave grains, maize and cereals particularly vulnerable. With this in mind, and considering that an estimated 25% of all crops show some signs of mycotoxin contamination, many countries have established regulatory guidelines for maximum mycotoxin limits in not only feed and grain, but also in processed food products.
Liquid chromatography-tandem mass spectrometry (LC/MS/MS) has become the method of choice for pesticide. The state of Oregon has issued regulatory limits for 59 pesticide residues in both cannabis flower and concentrates, while other states have come up with their own lists of pesticide residues relating to medical marijuana and cannabis testing.
A selective and sensitive LC/MS/MS method for fast identification and analysis of meat samples using three peptides specific for pork as biomarkers. . The optimized sample preparation procedure is easy to follow and can be used for analyzing raw, cooked and processed meat products. This method can selectively detect peptides from pork meat species at a threshold detection limit of 1% w/w (10 mg/g) in a variety of food products and thus the method can be useful for analysis of Halal food (or pork related food products) samples.
Analysis of target pesticide residues in berries using a unique laminar flow UHPLC-ESI-MS/MS
Since 2003 the usage of azo and non-azo dyes for food coloring has been declared as illegal by many of the food international authorities across the globe. That is because these substances such as Sudan I,II,III,IV and Rhodamine B, are potentially carcinogens and genotoxin in nature. As of now, no official methods have been published for the detection of illegal dyes however, the most used analytical technology is GC-MS or HPLC coupled with UV or MS detection.
Veterinary drugs are utilized extensively in modern day farming to prevent and treat animal diseases. However, use of these drugs must be carefully monitored, and failure to regulate the presence of residual veterinary drugs in animal tissues could pose a risk to human health if animal tissues with residual veterinary drugs are consumed. Many regulatory bodies, including the US FDA and Health Canada have developed maximum residue levels (MRLs) for residual veterinary drugs as a means to safe-guarding human health.
In this application note, a robust, high-throughput method for the analysis of 73 veterinary drugs in chicken tissue is presented. The method utilizes a fully automated solid phase micro-extraction (SPME) sample preparation technique, with subsequent analysis on a QSight® UHPLC/MS/MS.
Aflatoxin B1 is often found in animal feeds such as corn, cottonseed cake, groundnut meal, and other agricultural commodities. When these contaminated feeds are ingested by milk-producing animals, such as cattle, aflatoxin B1 can be converted to aflatoxin M1 (a hydroxy derivate of aflatoxin B1) by oxidation metabolism, and then excreted in milk. To protect consumers from the potential toxicity and carcinogenicity of aflatoxin M1, regulatory agencies have established regulatory limits or action levels for aflatoxin M1 in milk products.
In this study, a simple, fast, selective and sensitive LC/MS/MS method for the analysis of aflatoxin M1 is presented, along with the evaluation of three sample preparation methods.
Coumarin (1,2-benzopyrone) occurs as a natural component in some plants, and is utilized as a flavoring ingredient in some foods, tobaccos and cosmetic products. In recent years, coumarin has been added to electronic cigarette liquid nicotine solutions as a flavoring component, producing a complex flavor profile with aromas of vanilla, almond, cherry and cinnamon. Coumarin has been found to exhibit hepatoxic effects, and has been banned by the FDA in food products, but this ban does not extend to tobacco products, such as electronic cigarettes.
This application note details a method for the analysis of coumarin in electronic cigarette liquid nicotine cartridges, utilizing PerkinElmer UHPLC system coupled to a QSight® 220 triple quadrupole mass detector with a dual ionization source.
Mycotoxins are toxic secondary metabolites produced by fungi, and are capable of causing disease and death in both humans and animals. Sample preparation is a critical step in the successful analysis of mycotoxins in food matrices. The "dilute and shoot" approach is a quick and easy way to introduce the sample into the LC/MS/MS analysis. However, due to the complexity of food matrices, this approach will often result in irreproducible matrix effects. To overcome these problems and improve sensitivity, this application note details the use of online solid phase extraction (SPE), coupled to an LC/MS/MS system for sample enrichment.
Polycyclic aromatic hydrocarbons (PAHs) can contaminate foods during smoking, heating, and drying processes that allow combustion products to come into direct contact with food. They can also enter food supply chains through contaminated air and water, and accumulate in various food chains. Regulations are in place to monitor PAHs levels in foods; the EU set a stringent maximum residue limit (MRL) for BaP in muscle meat of smoked fish and smoked fishery products at 2 µg/kg.2 In this study, seafood samples were prepared using a QueChERS extraction method followed by a dispersive solid-phase extraction clean-up step. The samples were subsequently analyzed by coupling a UHPLC system with a triple quadrupole mass spectrometer.
Antibiotics are used in dairy cattle for different treatments, but it leads to accumulation of these residues in milk. Presence of such residues in human food can be responsible for allergic reactions, toxic effects and develops resistant strains of bacteria. To protect consumers, regulatory agencies in the European Union published several official documents to regulate the control of veterinary drugs. Council Directive 96/23/EC establishes the veterinary residue control in food producing animals. In India, as per FSSAI (gazette notification dated 20th July 2018) and EIC (RMP for Aquaculture, Egg, Honey, Milk Poultry etc.) it is a mandate to do the analysis of antibiotics. EIC and FSSAI both have maximum residue limits (MRLs) for various antibiotic residues for food matrices from animals. It is essential to test milk for residues of sulfonamides considering safety and prevent exposure of consumers to veterinary drugs. In this work, we present a fast and sensitive LC-MS/MS method for the quantitative analysis of sulfonamides antibiotics in milk.
Beta-adrenergic receptor agonists (ß- agonists) are synthetic drugs utilized in the treatment of conditions such as asthma in humans, and are also used as a growth-promoting agent in food-producing animals. The use of ß- agonists in food-producing livestock has been either banned or regulated across many countries owing to human health concerns.
To aid in the monitoring and detection of ß- agonists in livestock, a highly sensitive and selective analytical method has been developed, and is presented in this study. This LC/MS/MS method details the analysis of 13 ß- agonists in pork samples, and utilizes isotopically-labeled internal standards to compensate for matrix effects present in complex food matrices.
In this work, we present a fast and sensitive LC/MS/MS method
Analysis of glyphosate and similiar polar pesticides in oatmeal using the PerkinElmer QSight LCMSMS.
It is very well known that Black pepper is a complex matrix that requires a proper extraction and clean-up method for interferences. In this study, a fast, sensitive and selective multi-residue method has been developed for analysis of over 136 pesticides in Pepper samples by coupling a modified QuEChERS extraction method with LC/MS/MS. Using time-managed- MRM™ in the QSight™ triple quadrupole mass spectrometer, the optimum dwell time of multiple MRM transitions can be generated automatically for the targeted analytes. This not only saves time in method development but also improves data quality and analytical performance of instrument.
Endocrine disrupting chemicals (EDCs) have been found to have harmful effects on the health of both humans and wildlife. Of these EDCs, endogenous estrogens, such as estriol, 17ß-estriadiol, and estrone are of particular interest due to their potency/physiological activity even at very low levels. These hormones are particularly challenging to monitor, as concentrations are typically expected to be in the low ng/mL (ppb) to low pg/mL (ppt) range.
To improve sensitivity, this work utilizes the addition of on-line solid phase extraction (SPE) coupled to an LC/MS/MS system for sample enrichment and quantitation. This approach allows for significant/efficient analyte concentration, obviating the need for elaborate and time-consuming sample preparation procedures. Due to enrichment, compared to other methods, large sample volumes (= ½ liter) are no longer needed to reach part per trillion levels for estrogen monitoring in river water.
Drugs of abuse, which can trigger the user’s central nervous system and induce an altered state of mind, can be divided into different types, including stimulants such as cocaine, psychoactive substances such as LSD (lysergic acid diethylamide) and marijuana, and painkillers such as morphine and heroin. The identification and determination of these drugs in different matrices is essential for forensic and toxicology studies.
This work outlines a rapid LC/MS/MS method for the separation and detection of 44 drug of abuse compounds in urine samples, and evaluates the selectivity, linearity, and sensitivity of the QSight® 220 LC/MS/MS system.
Pesticides are employed in the growing of crops to prevent damage from a number of pests and fungi. When crops are grown to produce feed for livestock, there is a potential for pesticides residues to remain on the feeding stuffs, posing a risk to the livestock ingesting them. Pesticide residues are regulated by a number of governmental agencies, necessitating analytical methods that are robust enough to analyze complex matrices for a variety of analytes, while also being sensitive and selective enough to meet stringent regulations. In this application note, a fast, sensitive, and selective multi-residue method has been developed for the analysis of 94 pesticides in animal feeding stuffs, with reporting limits below European Commission MRLs of 0.01 mg/kg.
This work shows a reliable, sensitive and selective method for multi-mycotoxin determination in food samples using a PerkinElmer QSight 220 LC-MS/MS system. The method has been validated in eight different matrices and can be used in routine testing labs to meet regulatory requirements.
The Grape crop is one of the most important fruit crops consumed in the world. Grapes are consumed both as fresh and as processed products, such as wine, jam, juice, jelly, grape seed extract, raisins, vinegar and grape seed oil. A large variety of pesticides are used in grape production throughout its growing season to control pests and diseases in vineyards and to increase crop yield. Pesticide residue is a major concern for the stakeholders of the grape industry, due to more and more stringent regulations and safety standards in most countries.
Haloacetic acids (HAAs) are a class of undesired by-products resulting from the reaction of chlorinated disinfectants with natural organic matter in water, Which is known to be carcinogenic. The Japan Ministry of Health revised the inspection method for HAAs, which led to expansion of the analytical technique to include LC/MS/MS) as an alternative to the GC-MS method.
Aniline and aniline derivatives are widely used as raw materials and intermediates in the polymer, rubber, dye, pesticide and pharmaceutical industries. Unintended releases of aniliane or its derivatives into the environment pose a serious threat, with release possible during any stage of production, storage, transport, use, or disposal. Therefore, it is important and necessary to develop fast, simple, sensitive, selective and efficient methods for the determination of aniline and its derivatives in drinking and environmental waters. The aim of this study is to develop an LC/MS/MS method for rapid analysis of aniline and its derivatives in water samples by direct injection, without using time consuming sample preparation steps.
Cartridges containing cannabis extract or CBD are some of the cannabis industry’s fastest-growing major product categories. It is imperative that the composition of these products is understood to ensure that components in the product do not contribute to e-cigarette or vaping product use-associated lung injury (EVALI). Vitamin E acetate, often used as a thickening agent in the production of vape oils obtained in the illicit market, has been suggested to be a cause for EVALI.
In this application note, an LC/MS/MS method for the determination of vitamin E acetate (tocopherol acetate) in vape oil cartridges is presented. The method, which quantifies vitamin E acetate in less than three minutes utilizing a QSight® 420 triple quadrupole system, addresses the diversity and complexity of the cannabis and CBD matrix which have historically resulted in interferences that prevent rapid and accurate analysis.
This application note presents a sensitive and reliable LC/MS/MS method using the PerkinElmer QSight
Whether your lab is well established or just starting up, having a single-source partner who can offer turnkey solutions that meet the current regulations is essential to a successful business. For years, we’ve worked with government and contract cannabis laboratories to develop industry-leading methods, technology, and exceptional return on investment. We help drive analytical standards and commit to ensuring your laboratory has maximum uptime. Learn about our various testing methods and applications for cannabis analyses. Let us work with you to build an efficient workflow, so you can focus on growing your business and brand.
For third party food testing labs or producers who want to conduct aflatoxin M1 analysis in dairy products, our automated aflatoxin M1 ELISA assay and QSight LC/MS/MS aflatoxin M1 analyzer provide sensitive, accurate, and fit for purpose screening and confirmative analysis solutions that you can use out of box.
The grain industry is very complex. It’s global, diverse, and can also present analytical challenges. Today’s grain users demand more when it comes to quality, safety, and uniformity. In addition, they seek diverse products with unique characteristics.
PerkinElmer is equipped to help the grain industry in its quest to feed the world – nutritiously and economically. Our testing and analysis solutions encompass the three primary areas required for complete knowledge of grains and their derivatives – composition, functionality, and safety.
Food testing labs like yours are constantly challenged with accurately analyzing samples quickly and efficiently - all while striving to reduce costs due to market forces. Your commitment to ensuring meat and seafood are safe for consumption, as demand increases, is an uphill battle.
Our commitment to you: to provide a range of solutions across multiple technologies, products, and services that meets or exceeds the testing needs of food processors. Our solutions offer more efficiency and increased accuracy and sensitivity for better yields in real time with minimal training.
From instrumentation and software to consumables and reagents to service and support, we are dedicated to providing you with end-to-end solutions that ease your everyday challenges of automation, throughput, service, and time to results.
Pesticides can adversely affect human health through the food we consume but can also leach into soil and groundwater and impact us through the environment. To keep up with a complex and constantly changing regulatory environment, your pesticide analysis solution needs to keep up with your burgeoning sample load.
Our QSight triple quad LC/MS/MS family has always been known for its robust and reliable performance. But now there’s something new – something better: the high performance 400 series. Our ready-to-implement solution has the highest sensitivity and throughput the industry has ever seen and the capability to test for the most challenging samples and analytes.
Whether you’re a lab manager or a bench chemist, you know firsthand how things are changing quickly in food and environmental analysis. And your lab needs to change to keep pace.
Today’s advanced and increasingly diverse chromatography laboratories are facing new challenges on a daily basis – starting from raw materials right up to the finished product. Our comprehensive portfolio of analytical solutions is designed to give you the higher accuracy, sensitivity, and ease of use your laboratory demands for examining with confidence, the purity, composition, and performance of your compounds. What’s more, a range of complementary services is available to keep your laboratory up and running, meeting the stringent requirements of a variety of environments and working practices.
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Whatever your separation challenge, your choice of liquid chromatography (LC) column can make all the difference. Our Quasar portfolio of LC columns combined with the improved work?ow and usability of the LC 300 system allows you to achieve rugged and reproducible results. Now, with the purchase of an LC 300 system, you can pick out a Quasar LC column free of charge. Learn more below.
Our QSight triple quad LC/MS/MS family has always been known for its robust and reliable performance. But now there’s something new – something better: the high performance 400 series.
Our modular Simplicity 3Q™ software is ideal for acquiring, quantifying and reporting
Lab reequirements for QSight triple quad LC/MS/MS systems, including storage, suppleis, space, electrical, power, gas supply requirements
Simulation using sophisticated modeling techniques has become a powerful tool for mass spectrometry
Ion Transmission Through a Quadrupole Ion Guide Under the Combined Influence of Viscous Flow and RF
Theoretical Studies of Swirling Flow and Heating Methods on Droplet Evaporation in a Heated Coaxial