Ideal for analyzing food, cannabis, and environmental samples, our robust and reliable QSight® triple quad systems consistently deliver the throughput and productivity you need in your analytical testing lab. Now we’ve added the premier model to our QSight family: the high performance 400 series. This ready-to-implement solution has the highest sensitivity and throughput the industry has ever seen and the capability to test for the most challenging, complex samples, including cannabis.
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This workhorse system provides exceptional sensitivity for difficult matrices in commercial testing labs and the food, environmental, and cannabis industries – it’s the perfect instrument for labs that need uncompromising performance.
Achieve the highest levels of performance from sample handling right through results and reporting with QSight triple quad LC/MS/MS systems.
| Model Name | QSight 200 Series |
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In this study, we used the QSight LC/MS/MS system to evaluate the potential of eliminating sample preparation for trace level pesticide analysis in a complex sample such as wine. We injected undiluted red and white wine samples into the mass spectrometer and studied reproducibility in analysis of the spiked pesticides over 200 injections. The instrument showed excellent reproducibility with minimal signal drift during the duration of the study (over a week), confirming the robustness of the QSight mass spectrometer.
Multiclass, multiresidue method for analysis of 73 veterinary drugs (covering 13 different chemical classes) in chicken samples by coupling solvent extraction method with LC/MS/MS. Better recoveries were obtained for all the analytes without sample clean-up when comparing with different sample cleanup methods. Due to the high sensitivity of QSight mass spectrometer and its unique StayClean™ technology (hot-surface induced desolvation (HSID™) and Laminar Flow Ion Guide™),20 sample extracts can be analyzed directly without timeconsuming solvent evaporation and analyte concentration steps.
A New, Sensitive Method for Lignan Metabolite Detection of Flaxseed-Fed Mice Using LC/MS/MS
Testing for the levels of pesticide and mycotoxins in cannabis is important to ensure consumer safety and quality control. In this work, the PerkinElmer application development team analyzed all 66 pesticides (including very hydrophobic and chlorinated pesticides typically analyzed by GC-MS/MS) and five mycotoxins spiked in cannabis flower extracts well below the action limits specified by the state of California. A LC-MS/MS instrument was used with ESI and APCI sources and a simple solvent extraction method with excellent recoveries for all analytes in acceptable range of 70-120%.
Acrylamide is an amide-type organic compound that can be formed by cooking or processing food at elevated temperatures . We have developed a rapid, sensitive and reproducible HPLC-MS/MS method for analysis of acrylamide in potato chips, using a simple sample preparation procedure. The LOQ is 25 µg/kg. The QSight mass spectrometer provides a robust platform for analysis of trace acrylamide levels in compilance with European Regulation. This method can also be applied to other types of regulated matrices such as bread, biscuits, breakfast cereals, and more.
This application note demonstrates the effective chromatographic separation of aflatoxins B1, B2, G1, G2 and M1 by UHPLC-MS/MS, achieving the 0.05-ppb control limit for M1 without the need for derivatization.
Haloacetic acids (HAAs) are a class of undesired by-products resulting from the reaction of chlorinated disinfectants with natural organic matter in water. The resulting substances are considered major disinfection by-products (DBP), which are known for being carcinogenic and also associated with reproductive problems in humans. The five major HAAs of particular concern include monochloroacetic acid (MCAA), monobromoacetic acid (MBAA), dichloroacetic acid (DCAA), dibromoacetic acid (DBAA) and trichloroacetic acid (TCAA). Haloacetic acids are regulated by the U.S. Environmental Protection Agency (EPA) government. In this application note, a reliable and fast method for determination and quantification of five HAAs in potable drinking water is presented using a PerkinElmer QSight® LX50 UHPLC system coupled to a PerkinElmer QSight 220 MS/MS detector. The five HAAs eluted within three minutes with excellent reproducibility.
Liquid chromatography tandem mass spectrometry (LC/MS/MS) has become the method of choice for pesticide analysis due to its high selectivity and sensitivity as well as its suitability for a wide range of compounds in various sample matrices. 0 In this study, a fast, sensitive and selective multi- residue method has been developed for analysis of over 200 pesticides in rice samples by coupling a modified QuEChERS extraction method with LC/MS/MS. Using time-managed- MRM™ in the QSight® triple quadrupole mass spectrometer, the optimum dwell time of multiple MRM transitions can be generated automatically for the targeted analytes. This not only saves time in method development but also improves data quality and analytical performance, as demonstrated in this study by the results of multi- residue pesticide analysis in rice samples.
An effective, reliable and robust LC-MS/MS method, using time-managed MRM (Multiple Reaction Monitoring) transitions, for the monitoring of mycotoxins in multi-grain and corn cereals at low µg/kg levels, without the need for derivatization. The analyzed mycotoxins included aflatoxins B1, B2, G1, G2, ochratoxin A, HT-2 and T-2 toxins, ergocristine and fumonisins F-B1 and F-B2.
Pharmaceutical and Personal Care Products (PPCPs) are an emerging environmental concern, and include human and veterinary prescription and over-the-counter medications, sunscreens, lotions, soaps, and insect repellants. These commonly encountered products can enter the environment through various sources, including municipal wastewater, polluting ground water, surface water, and even drinking water. The analytical challenge associated with PPCP testing is the wide variety of chemical classes/ types that are typically present at parts per trillion (ng/L) concentrations in drinking water. The automated approach described in this application note allows for significant and efficient analyte concentration, obviating the need for elaborate and time-consuming sample preparation procedures, and thus improving productivity, reducing solvent usage and laboratory waste.
A selective and sensitive LC/MS/MS method for fast identification and analysis of meat samples using three peptides specific for pork as biomarkers. . The optimized sample preparation procedure is easy to follow and can be used for analyzing raw, cooked and processed meat products. This method can selectively detect peptides from pork meat species at a threshold detection limit of 1% w/w (10 mg/g) in a variety of food products and thus the method can be useful for analysis of Halal food (or pork related food products) samples.
In the present study, a unique laminar flow UPLC-ESI-MS/MS triple quad mass spectrometer was used to identify and quantitate 40 pesticides in four brands of nonorganic berries. The QuEChERs extraction method proved both rapid and reliable for extracting pesticide residues in the heavily pigmented berry samples. These results obtained demonstrate this methods applicability and effectiveness in detecting and quantitating pesticides lower than 10 parts per billion (ppb), per regulatory limits set by the EU directive 91/414/EEC.
Water-soluble vitamins (WSV), comprised primarily of the vitamin B complex, are essential ingredients in many foods, particularly in infant formulas. When analyzing fortified foods, this can be particularly challenging due to the wide range in concentration of vitamins, in keeping with daily allowances. This application note presents a LC-MS/MS method for the efficient, routine and robust chromatographic analysis of B-vitamins in infant formula. Eight water soluble vitamins over a wide concentration range were identified and quantified in under four minutes. The results showed excellent retention time repeatability and the method was able to detect vitamin B12 at 0.5 ppb, well below the expected level of ~2 ppb in infant formulas.
A recent recall of contaminated eggs in Europe has generated a serious health concern for fipronil poisoning. Fipronil is a highly toxic insecticide and it is used to protect crops. The U.S. EPA has classified fipronil as a group C carcinogen. In this study, we describe a fast and robust analytical method for identifying fipronil and its metabolites with the PerkinElmer QSight® 200 series LC/MS/MS triple quadrupole instrument. The results demonstrate excellent recovery, linearity and reproducibility and superior sensitivity for this method. The three-step sample preparation procedure is quick and easy, and the LC/MS/MS analysis time can be carried out within six minutes with great separation for all analytes.
Coumarin (1,2-benzopyrone) occurs as a natural component in some plants, and is utilized as a flavoring ingredient in some foods, tobaccos and cosmetic products. In recent years, coumarin has been added to electronic cigarette liquid nicotine solutions as a flavoring component, producing a complex flavor profile with aromas of vanilla, almond, cherry and cinnamon. Coumarin has been found to exhibit hepatoxic effects, and has been banned by the FDA in food products, but this ban does not extend to tobacco products, such as electronic cigarettes.
This application note details a method for the analysis of coumarin in electronic cigarette liquid nicotine cartridges, utilizing PerkinElmer UHPLC system coupled to a QSight® 220 triple quadrupole mass detector with a dual ionization source.
Mycotoxins are toxic secondary metabolites produced by fungi, and are capable of causing disease and death in both humans and animals. Sample preparation is a critical step in the successful analysis of mycotoxins in food matrices. The “dilute and shoot” approach is a quick and easy way to introduce the sample into the LC/MS/MS analysis. However, due to the complexity of food matrices, this approach will often result in irreproducible matrix effects. To overcome these problems and improve sensitivity, this application note details the use of online solid phase extraction (SPE), coupled to an LC/MS/MS system for sample enrichment.
Polycyclic aromatic hydrocarbons (PAHs) can contaminate foods during smoking, heating, and drying processes that allow combustion products to come into direct contact with food. They can also enter food supply chains through contaminated air and water, and accumulate in various food chains. Regulations are in place to monitor PAHs levels in foods; the EU set a stringent maximum residue limit (MRL) for BaP in muscle meat of smoked fish and smoked fishery products at 2 µg/kg.2 In this study, seafood samples were prepared using a QueChERS extraction method followed by a dispersive solid-phase extraction clean-up step. The samples were subsequently analyzed by coupling a UHPLC system with a triple quadrupole mass spectrometer.
In apiculture, sulfonamides are the most commonly used antibiotics to treat American and European Foulbrood, a type of disease that infects bees. This application note demonstrates how QSight 200 System can provides a very sensitive and robust platform for the analysis of sulfonamides in honey.
Antibiotics are used in dairy cattle for different treatments, but it leads to accumulation of these residues in milk. Presence of such residues in human food can be responsible for allergic reactions, toxic effects and develops resistant strains of bacteria. To protect consumers, regulatory agencies in the European Union published several official documents to regulate the control of veterinary drugs. Council Directive 96/23/EC establishes the veterinary residue control in food producing animals. In India, as per FSSAI (gazette notification dated 20th July 2018) and EIC (RMP for Aquaculture, Egg, Honey, Milk Poultry etc.) it is a mandate to do the analysis of antibiotics. EIC and FSSAI both have maximum residue limits (MRLs) for various antibiotic residues for food matrices from animals. It is essential to test milk for residues of sulfonamides considering safety and prevent exposure of consumers to veterinary drugs. In this work, we present a fast and sensitive LC-MS/MS method for the quantitative analysis of sulfonamides antibiotics in milk.
In this work, we present a fast and sensitive LC/MS/MS method
Glyphosate (N-(phosphonomethyl) glycine), an organophosphorus compound, is used to kill weeds (e.g. annual broadleaf weeds and grasses) that compete with crops. Like other pesticides, glyphosate is directly administered to food products and can come in contact with both food workers and the environment, resulting in the bio burden of exposure in uncontrolled regional populations. Our study reports a 12 minute LC/MS/MS method with an amino-based column to analyze glyphosate and other related polar compounds in underivatized states, with exceptional selectivity and sensitivity.
It is very well known that Black pepper is a complex matrix that requires a proper extraction and clean-up method for interferences. In this study, a fast, sensitive and selective multi-residue method has been developed for analysis of over 136 pesticides in Pepper samples by coupling a modified QuEChERS extraction method with LC/MS/MS. Using time-managed- MRM™ in the QSight™ triple quadrupole mass spectrometer, the optimum dwell time of multiple MRM transitions can be generated automatically for the targeted analytes. This not only saves time in method development but also improves data quality and analytical performance of instrument.
Endocrine disrupting chemicals (EDCs) have been found to have harmful effects on the health of both humans and wildlife. Of these EDCs, endogenous estrogens, such as estriol, 17ß-estriadiol, and estrone are of particular interest due to their potency/physiological activity even at very low levels. These hormones are particularly challenging to monitor, as concentrations are typically expected to be in the low ng/mL (ppb) to low pg/mL (ppt) range.
To improve sensitivity, this work utilizes the addition of on-line solid phase extraction (SPE) coupled to an LC/MS/MS system for sample enrichment and quantitation. This approach allows for significant/efficient analyte concentration, obviating the need for elaborate and time-consuming sample preparation procedures. Due to enrichment, compared to other methods, large sample volumes (= ½ liter) are no longer needed to reach part per trillion levels for estrogen monitoring in river water.
Drugs of abuse, which can trigger the user’s central nervous system and induce an altered state of mind, can be divided into different types, including stimulants such as cocaine, psychoactive substances such as LSD (lysergic acid diethylamide) and marijuana, and painkillers such as morphine and heroin. The identification and determination of these drugs in different matrices is essential for forensic and toxicology studies.
This work outlines a rapid LC/MS/MS method for the separation and detection of 44 drug of abuse compounds in urine samples, and evaluates the selectivity, linearity, and sensitivity of the QSight® 220 LC/MS/MS system.
Both pesticides and illegal additives, if present in significant levels in wine, can pose health risk to consumers. In this study, a simple and sensitive LC-MS/MS method has been developed and applied for the determination of both pesticides and pigments in a single analytical run.
Pesticide residue is a major concern for the stakeholders of the grape industry, due to more and more stringent regulations and safety standards in most countries. In this study, a fast, sensitive and selective multi-residue method has been developed by coupling QuEChERS sample preparation with LC-MS/MS. Using time-managed-MRM™ in the QSight™ triple quadrupole mass spectrometer, the optimum dwell time can be generated automatically for MRM transitions based on the number of co-eluting transitions, expected cycle time, retention time and tolerance time window of the targeted analytes. Such method automation results in improved data quality, better sensitivity, accuracy, and reproducibility, as demonstrated in this study by the results of 213 pesticide residues analyzed in grape samples.
Aniline and aniline derivatives are widely used as raw materials and intermediates in the polymer, rubber, dye, pesticide and pharmaceutical industries. Unintended releases of aniliane or its derivatives into the environment pose a serious threat, with release possible during any stage of production, storage, transport, use, or disposal. Therefore, it is important and necessary to develop fast, simple, sensitive, selective and efficient methods for the determination of aniline and its derivatives in drinking and environmental waters. The aim of this study is to develop an LC/MS/MS method for rapid analysis of aniline and its derivatives in water samples by direct injection, without using time consuming sample preparation steps.
This application note presents a sensitive and reliable LC/MS/MS method using the PerkinElmer QSight
A simple and sensitive method for the simultaneous determination of plant growth regulators
Learn more about our various testing methods and applications for cannabis analyses by reading through our Cannabis Testing brochure.
The grain industry is very complex. It’s global, diverse, and can also present analytical challenges. Today’s grain users demand more when it comes to quality, safety, and uniformity. In addition, they seek diverse products with unique characteristics.
PerkinElmer is equipped to help the grain industry in its quest to feed the world – nutritiously and economically. Our testing and analysis solutions encompass the three primary areas required for complete knowledge of grains and their derivatives – composition, functionality, and safety.
Pesticides can adversely affect human health through the food we consume but can also leach into soil and groundwater and impact us through the environment. To keep up with a complex and constantly changing regulatory environment, your pesticide analysis solution needs to keep up with your burgeoning sample load.
Our QSight triple quad LC/MS/MS family has always been known for its robust and reliable performance. But now there’s something new – something better: the high performance 400 series. Our ready-to-implement solution has the highest sensitivity and throughput the industry has ever seen and the capability to test for the most challenging samples and analytes.
Our QSight triple quad LC/MS/MS family has always been known for its robust and reliable performance. But now there’s something new – something better: the high performance 400 series.
Our modular Simplicity 3Q™ software is ideal for acquiring, quantifying and reporting
Lab reequirements for QSight triple quad LC/MS/MS systems, including storage, suppleis, space, electrical, power, gas supply requirements
Product Certificate for the QSight 110 & 120
Product Certificate for the QSight 210 & 220
Simulation using sophisticated modeling techniques has become a powerful tool for mass spectrometry
Ion Transmission Through a Quadrupole Ion Guide Under the Combined Influence of Viscous Flow and RF
Theoretical Studies of Swirling Flow and Heating Methods on Droplet Evaporation in a Heated Coaxial
