PerkinElmer
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QSight LX50 Solvent Delivery Module

Our QSight® LX50 UHPLC integrates seamlessly to our QSight Triple Quad LC/MS/MS and its Simplicity software to deliver the highest levels of performance from sample handling through data collection and reporting. The system includes three key technologies that help optimize your workflow and enable high productivity.

Part Number N2991000
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Overview

For the QSight triple quad LC/MS/MS, we’ve paired the industry’s most flexible mass spectrometer with the equally capable QSight LX50 UHPLC system, delivering all the sensitivity and specificity you need for demanding applications such as pesticide-residue and nutritional-component analysis. And with its robust design and carryover-elimination capabilities, the system is perfect for a host of other applications in the food and environmental arenas.

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Application Note

"No Dilute” Just Shoot: Robustness of a QSight LC-ESI-MS/MS for Pesticide Residue Analysis in Wine

QSight LC/MS/MS evaluates eliminating sample preparation for trace level pesticide in wine

PDF 962 KB
A New, Sensitive Method for Lignan Metabolite Detection of Flaxseed-Fed Mice Using LC/MS/MS

A New, Sensitive Method for Lignan Metabolite Detection of Flaxseed-Fed Mice Using LC/MS/MS

PDF 1 MB
A Single Cannabis Method to Meet California Pesticide and Mycotoxin Residues Regulatory Requirements

Testing for the levels of pesticide and mycotoxins in cannabis is important to ensure consumer safety and quality control. In this work, the PerkinElmer application development team analyzed all 66 pesticides (including very hydrophobic and chlorinated pesticides typically analyzed by GC-MS/MS) and five mycotoxins spiked in cannabis flower extracts well below the action limits specified by the state of California. A LC-MS/MS instrument was used with ESI and APCI sources and a simple solvent extraction method with excellent recoveries for all analytes in acceptable range of 70-120%.

PDF 2 MB
Analysis of Acrylamide in Potato Chips by Isotopically Standard Addition UHPLC-MS/MS

Acrylamide is a probable carcinogen organic compound that is found in some foods that are cooked at elevated temperatures. It’s origins are due to the condensation of the amino acid asparagine and glucose as part of Maillard reaction. In 2002, Acrylamide was found to be present in french fries and baked bread. This compound has now also been found in some other food stuff like coffee, black olives, dried pears, and peanuts. As a result the and World Health Organizations have promptly limited its presence for human consumption.

PDF 1 MB
Analysis of Aflatoxins by UHPLC

Aflatoxin B1 is considered to be the most genotoxic of the mycotoxins, and, when ingested by cows, is converted to aflatoxin M1 which has been shown to cause liver cancer in certain animals.

PDF 1 MB
Analysis of Multi-Residue Pesticides in Rice by LC/MS/MS

Liquid chromatography tandem mass spectrometry (LC/MS/MS) has become the method of choice for pesticide analysis due to its high selectivity and sensitivity as well as its suitability for a wide range of compounds in various sample matrices. 0 In this study, a fast, sensitive and selective multi- residue method has been developed for analysis of over 200 pesticides in rice samples by coupling a modified QuEChERS extraction method with LC/MS/MS. Using time-managed- MRM in the QSight® triple quadrupole mass spectrometer, the optimum dwell time of multiple MRM transitions can be generated automatically for the targeted analytes. This not only saves time in method development but also improves data quality and analytical performance, as demonstrated in this study by the results of multi- residue pesticide analysis in rice samples.

PDF 1 MB
Analysis of Mycotoxins in Multi-Grain and Corn Cereals

Mycotoxins produced by fungi as toxic secondary metabolites, leave grains, maize and cereals particularly vulnerable. With this in mind, and considering that an estimated 25% of all crops show some signs of mycotoxin contamination, many countries have established regulatory guidelines for maximum mycotoxin limits in not only feed and grain, but also in processed food products.

PDF 991 KB
Analysis of Pesticide Residues in Cannabis Regulated by Oregon State Using LC/MS/MS

Liquid chromatography-tandem mass spectrometry (LC/MS/MS) has become the method of choice for pesticide. The state of Oregon has issued regulatory limits for 59 pesticide residues in both cannabis flower and concentrates, while other states have come up with their own lists of pesticide residues relating to medical marijuana and cannabis testing.

PDF 1 MB
Analysis of Target Pesticide Residues in Berries with LC/MS/MS Coupled with a QuEChERS Sample Prep

Analysis of target pesticide residues in berries using a unique laminar flow UHPLC-ESI-MS/MS

PDF 1 MB
Analysis of Water-Soluble Vitamins in Infant Formula by UHPLC-MS MS

Water-soluble vitamins (WSV), comprised primarily of the vitamin B complex, are essential ingredients in many foods, particularly in infant formulas. When analyzing fortified foods, this can be particularly challenging due to the wide range in concentration of vitamins, in keeping with daily allowances. This application note presents a LC-MS/MS method for the efficient, routine and robust chromatographic analysis of B-vitamins in infant formula. Eight water soluble vitamins over a wide concentration range were identified and quantified in under four minutes. The results showed excellent retention time repeatability and the method was able to detect vitamin B12 at 0.5 ppb, well below the expected level of ~2 ppb in infant formulas.

PDF 1 MB
Analysis of illegal dyes in Chili Spices via UHPLC-MS/MS

Since 2003 the usage of azo and non-azo dyes for food coloring has been declared as illegal by many of the food international authorities across the globe. That is because these substances such as Sudan I,II,III,IV and Rhodamine B, are potentially carcinogens and genotoxin in nature. As of now, no official methods have been published for the detection of illegal dyes however, the most used analytical technology is GC-MS or HPLC coupled with UV or MS detection.

PDF 4 MB
Detection of Fipronil and Metabolites in Eggs by LC-MS/MS

Fipronil is a broad-spectrum phenylpyrazole insecticide almost used to protect corps from insects but also to treat lice and ticks in chickens. The U.S. EPA classified fipronil as Group C, possible human carcinogen, therefore International organizations defined admissible limits for the fipronil usage which in egg is of 5 µg/L4. LC-MS/MS technology can provide a robust and reliable method to detect such a contaminant in food.

PDF 719 KB
Determination of Polycyclic Aromatic Hydrocarbons in Seafood by UHPLC- MS/MS

Polycyclic aromatic hydrocarbons (PAHs) can contaminate foods during smoking, heating, and drying processes that allow combustion products to come into direct contact with food. They can also enter food supply chains through contaminated air and water, and accumulate in various food chains. Regulations are in place to monitor PAHs levels in foods; the EU set a stringent maximum residue limit (MRL) for BaP in muscle meat of smoked fish and smoked fishery products at 2 µg/kg.2 In this study, seafood samples were prepared using a QueChERS extraction method followed by a dispersive solid-phase extraction clean-up step. The samples were subsequently analyzed by coupling a UHPLC system with a triple quadrupole mass spectrometer.

PDF 1 MB
Determination of Sulfonamides in Honey

In apiculture, sulfonamides are the most commonly used antibiotics to treat American and European Foulbrood, a type of disease that infects bees. This application note demonstrates how QSight 200 System can provides a very sensitive and robust platform for the analysis of sulfonamides in honey.

PDF 1 MB
Determination of Sulfonamides in milk by Ultra-Performance Liquid Chromatography coupled with Tandem Mass Spectrometry (QSight™)

Antibiotics are used in dairy cattle for different treatments, but it leads to accumulation of these residues in milk. Presence of such residues in human food can be responsible for allergic reactions, toxic effects and develops resistant strains of bacteria. To protect consumers, regulatory agencies in the European Union published several official documents to regulate the control of veterinary drugs. Council Directive 96/23/EC establishes the veterinary residue control in food producing animals. In India, as per FSSAI (gazette notification dated 20th July 2018) and EIC (RMP for Aquaculture, Egg, Honey, Milk Poultry etc.) it is a mandate to do the analysis of antibiotics. EIC and FSSAI both have maximum residue limits (MRLs) for various antibiotic residues for food matrices from animals. It is essential to test milk for residues of sulfonamides considering safety and prevent exposure of consumers to veterinary drugs. In this work, we present a fast and sensitive LC-MS/MS method for the quantitative analysis of sulfonamides antibiotics in milk.

PDF 579 KB
PDF 1 MB
Direct Analysis of Glyphosate and Similar Polar Pesticides in Oatmeal by UHPLC-MS/MS

Analysis of glyphosate and similiar polar pesticides in oatmeal using the PerkinElmer QSight LCMSMS.

PDF 1 MB
Estimation of 136 pesticide residue in Black Pepper using QuEChERS extraction technique and QSight™ LC-MS/MS

It is very well known that Black pepper is a complex matrix that requires a proper extraction and clean-up method for interferences. In this study, a fast, sensitive and selective multi-residue method has been developed for analysis of over 136 pesticides in Pepper samples by coupling a modified QuEChERS extraction method with LC/MS/MS. Using time-managed- MRM in the QSight triple quadrupole mass spectrometer, the optimum dwell time of multiple MRM transitions can be generated automatically for the targeted analytes. This not only saves time in method development but also improves data quality and analytical performance of instrument.

PDF 1 MB
Method Validation for Atrazine Analysis in Fresh, Atypical Mineral and Carbonated Waters

EU water policies are reevaluated on a consistent basis to ensure water sources do not contain contaminants at levels above regulatory levels. As regulations are reviewed, regulatory limits are often lowered, and analytical techniques must adapt to meet the new stringent requirements.

In this application note, an LC/MS/MS method for the determination of 214 regulated contaminants is presented. The direct injection method, utilizing a PerkinElmer® QSight 420, is optimized with the use of dual ionization sources (APCI and ESI). Additionally, an inter-laboratory study is detailed to illustrate the method transferability between instruments, utilizing the compound Atrazine.

PDF 1 MB
Multi-residue Analysis of Pesticides in Animal Feed Using the QSight LC/MS/MS

Pesticides are employed in the growing of crops to prevent damage from a number of pests and fungi. When crops are grown to produce feed for livestock, there is a potential for pesticides residues to remain on the feeding stuffs, posing a risk to the livestock ingesting them. Pesticide residues are regulated by a number of governmental agencies, necessitating analytical methods that are robust enough to analyze complex matrices for a variety of analytes, while also being sensitive and selective enough to meet stringent regulations. In this application note, a fast, sensitive, and selective multi-residue method has been developed for the analysis of 94 pesticides in animal feeding stuffs, with reporting limits below European Commission MRLs of 0.01 mg/kg.

PDF 3 MB
NDMA in ranitidine drug substance by QSight™ UHPLC-MS/MS

N-nitroso dimethylamine (NDMA) is one of nitrosamine class impurities classified as a probable human carcinogen (a substance that could cause cancer). NDMA is a known environmental contaminant and found in water and foods, including meats, dairy products and vegetables. The European Medicines Agency (EMA) and theUS Food and Drug Administration (US FDA) have been investigating NDMA and similar nitrosamines compounds since 2018 when they were found in a number of angiotensin II receptor blockers (ARBs), blood pressure medicines known as ‘sartans’, leading to some recalls.

PDF 2 MB
Novel ESI and APCI LC/MS/MS Method for Testing Cannabis and Hemp Concentrate Samples

The use of cannabis concentrates and CBD products (edibles, topicals, vape products, etc.) has increased in popularity as new regulation has been passed legalizing medicinal and recreational use in a number of states and provinces. Testing to ensure that pesticide and mycotoxin levels in cannabis products are below regulatory levels is critical, however, the cannabis concentrate matrix presents many analytical challenges including higher sample matrix effects and an increased concentration of cannabinoids in the sample.

In this application note, an LC/MS/MS method for the analysis of 66 pesticides (including hydrophobic and chlorinated pesticides typically analyzed by GC/MS/MS) and five mycotoxins in a cannabis concentrate matrix is presented. Utilizing a QSight® 420 LC/MS/MS instrument with dual APCI and ESI sources, the analysis yielded excellent recoveries and detection limits below those specified by the state of California cannabis regulations.

PDF 1 MB
Pesticide Residues and Illegal Additives in Wine

Both pesticides and illegal additives, if present in significant levels in wine, can pose health risk to consumers. In this study, a simple and sensitive LC-MS/MS method has been developed and applied for the determination of both pesticides and pigments in a single analytical run.

PDF 1006 KB
Rapid Determination of Trace Amounts of Aniline and Its Derivatives by Direct Injection UHPLC/MS/MS

Aniline and aniline derivatives are widely used as raw materials and intermediates in the polymer, rubber, dye, pesticide and pharmaceutical industries. Unintended releases of aniliane or its derivatives into the environment pose a serious threat, with release possible during any stage of production, storage, transport, use, or disposal. Therefore, it is important and necessary to develop fast, simple, sensitive, selective and efficient methods for the determination of aniline and its derivatives in drinking and environmental waters. The aim of this study is to develop an LC/MS/MS method for rapid analysis of aniline and its derivatives in water samples by direct injection, without using time consuming sample preparation steps.

PDF 587 KB
Simultaneous Detection of Estrogenic and Progestogenic Hormones in Edible Bird's Nest

This application note presents a sensitive and reliable LC/MS/MS method using the PerkinElmer QSight

PDF 859 KB
Simultaneous Determination of Plant Growth Regulators in Bean Sprouts

A simple and sensitive method for the simultaneous determination of plant growth regulators

PDF 2 MB

Brochure

QSight Pesticides Analyzer Brochure

Pesticides can adversely affect human health through the food we consume but can also leach into soil and groundwater and impact us through the environment. To keep up with a complex and constantly changing regulatory environment, your pesticide analysis solution needs to keep up with your burgeoning sample load.

PDF 9 MB
QSight Triple Quadrupole LC/MS/MS

Whether you’re a lab manager or a bench chemist, you know firsthand how things are changing quickly in food and environmental analysis. And your lab needs to change to keep pace.

PDF 8 MB

Product Note

PDF 890 KB
QSight Simplicity 3Q Software Suite

Our modular Simplicity 3Q™ software is ideal for acquiring, quantifying and reporting

PDF 1 MB
QSight Triple Quadrupole LC/MS/MS Preparing Your Lab

Lab reequirements for QSight triple quad LC/MS/MS systems, including storage, suppleis, space, electrical, power, gas supply requirements

PDF 660 KB

Technical Note

Flow Characteristics of a Laminar Flow Interface for LC/MS/MS

Simulation using sophisticated modeling techniques has become a powerful tool for mass spectrometry

PDF 1 MB
Ion Transmission Through a Quadrupole Ion Guide

Ion Transmission Through a Quadrupole Ion Guide Under the Combined Influence of Viscous Flow and RF

PDF 1 MB
Theoretical Studies of Swirling Flow and Heating Methods

Theoretical Studies of Swirling Flow and Heating Methods on Droplet Evaporation in a Heated Coaxial

PDF 503 KB