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Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.
The presence of ethylene glycol in used motor oil is an indication of antifreeze coolant leakage into the crankcase of an internal combustion engine, thus predicting engine-wear problems. A practical method has been developed and tested which will allow for high throughput testing of ethylene glycol as a diluent in used motor oil. Up to 400 samples per day can be analyzed using this method, which provides results directly comparable to established methods.