Search Results for 'LAMBDA Bio'

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  • Application Note

    Characterization of Iron Gall Ink on Paper in Artificial Aging Processes

    Historical manuscripts are subject to deterioration due to aging processes under different storage and handling conditions. There can be physical, chemical and biological factors with different impact on papers and parchments or inks and dyes. Optical methods are preferred for the evaluation of historic manuscripts because of its non-destructive character. Changes in color and material composition can be correlated to optical parameters. Iron gall inks are known to cause damage to cellulose, the main component in papers. Light-induced fading or color change of a material, a form of photochemical damage caused by the absorption of optical radiation, can be monitored by absorption and reflection measurements.

    This application note describes how the PerkinElmer LAMBDA 1050+ Wide Band spectrometer in combination with the 150 mm integrating sphere combination provides an excellent platform for the spectral characterization of manuscript materials in ageing processes.

  • Application Note

    The Determination of Total Protein Using the LAMBDA UV/Vis Spectrophotometer: Bradford Method

    Quantification methods for total protein are among the longest-established fundamental and important experiments of bioscience. UV/Vis Spectrophotometry is widely used for the determination of protein. This application note describes a typical protein method, the Bradford method. Data is rapidly acquired using the LAMBDA™ 465 UV/Vis Spectrophotometer and processed using the UV Lab Software.

  • Application Brief

    Determination of Monoclonal Antibody Aggregation using UV/Vis Spectroscopy

    Monoclonal antibodies are becoming more widespread as treatments for a variety of diseases including osteoporosis and various cancers. Furthermore, monoclonal antibodies have received emergency authorization for use as treatment for SARS-CoV-2, or COVID-19, from the FDA under the drug names casirivimab and imdevimab. Aggregation of antibodies may take place due to unwanted folding of the protein structure and can be influenced by a wide variety of factors including pH, presence of other free bases and, most importantly for this application, temperature.

    Aggregation index provides a semi-quantitative view of the extent of aggregation in antibodies and can be determined by simply measuring the UV/Visible spectrum of the material. UV/Visible spectroscopy provides a fast method for estimation of the extent to which antibodies have become aggregated. This application brief describes how the PerkinElmer LAMBDA 465 with UVLab software allows users to measure samples in less than one minute.

  • Poster

    Infographic - Solutions for your Toxicology Lab

    Infographic Poster showing the range of different analytical solutions for Toxicology Labs; from GC and LC, to ICP-MS and UV-Vis. Benchtop and floor standing chromatography, spectroscopy and thermal solutions for everyday robust and reliable analyses.


  • Application Note

    Spectral Transmission of Pharmaceutical Containers in Accordance with USP <671>

    All medicinal products need to be protected and packaged in containers which conform to prescribed standards. The quality of pharmaceutical packaging can have a significant impact on the performance of pharmaceutical products and can reduce shelf-life if the improper packaging is used. The USP chapter, <671>, “Containers – Performance Testing” provides standards for the functional properties of packaging systems used for solid and liquid oral dosage forms for pharmaceuticals and dietary supplements. This application note demonstrates the determination of spectral transmission of plastic pharmaceutical containers using the PerkinElmer LAMBDA 1050+ UV/Vis/NIR spectrophotometer, in accordance with USP <671>.