The application brief details the use of the PerkinElmer Pyris™ TGA 9 for determining the loss on drying of a pharmaceutical excipient, specifically microcrystalline cellulose. Loss on drying is essential to measure because it affects the stability, processing characteristics, and longevity of pharmaceutical products. The Pyris TGA 9 allows for rapid quantification of moisture content without additional cooling accessories, starting at sub-ambient temperatures to prevent premature evaporation of volatiles. The Pyris software facilitates the data analysis, helping to accurately determine sample characteristics. The app brief emphasizes the Pyris TGA 9's ability to perform accurately in sub-ambient conditions, enhancing the reliability of loss on drying measurements for pharmaceuticals and other materials.