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IVISense™ Cat K 680 FAST NIR fluorescent probe enables monitoring and quantifying cathepsin K (Cat K) activity.
Cat K is a lysosomal cysteine protease expressed in osteoclasts, chondrocytes, and synovial fibroblasts and is involved in bone resorption and collagen degradation. Women with osteoporosis, breast cancer and bone metastases are reported to have high levels of Cat K. The high expression levels of Cat K is a good marker for not only better understanding bone modeling and remodeling, but evaluating inhibitors of Cat K for potential therapeutics.
For research use only. Not for use in diagnostic procedures.