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The NexSAR™ HPLC, is a next-generation Speciation Analysis Ready system engineered with a completely inert and metal-free fluid path, enabling laboratories to meet low chromatographic background requirements on the most challenging speciation applications. Plus, it is fully customizable, with the flexibility to select only the parts that you need for your application(s).
This system is part of the NexSAR HPLC-ICP-MS Speciation Solution, which couples the NexSAR HPLC with our revolutionary NexION® ICP-MS and is seamlessly integrated using the proven Clarity™ software.
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Speciation studies can provide comprehensive information regarding ion mobility, bioavailability, and toxicity. Consequently, many modern labs are expanding their analytical portfolio to include HPLC-ICP-MS. For such studies, it is advantageous to have an intuitive, user-friendly system that meets the user requirements for automation, ultra-low baseline, powerful integration, and flexible data export. And no one offers a more integrated, versatile, and inert speciation solution than PerkinElmer - accelerate your speciation analysis with the NexSAR™ HPLC-ICP-MS Speciation Solution.
This application describes an analytical method for the chromatographic separation and quantitative monitoring of seven primary cannabinoids, including THC and THC-A, in cannabis extracts by HPLC with PDA detection. Naturally occurring cannabinoids, the main biologically active component of the cannabis plant, form a complex group of closely related compounds, of which 113 are known and 70 are well described. Of these, the primary focus has been on ?9-tetrahydrocannabinol (THC), as the primary active ingredient due to its pharmacological and toxicological characteristics, upon which strict legal limits have been enforced.
Indoxyl sulfate is one of the most extensively studied solutes that accumulates in the plasma when the kidneys fail. Originally called "indican", it was first isolated by Obermayer and Popper in 1911. High concentrations of indoxyl sulfate in blood plasma are known to be associated with the development and progression of a number of pathological conditions including chronic kidney disease and vascular disease. The scientific literature documents the use of older generation C18 columns, using type A silicas. This application brief will illustrate the application of a new generation C18 column, based on type B silica, for the analysis of indoxyl sulfate, Figure 1, as part of a research study to measure the total levels in a simulated blood serum environment.
Water polluted by herbicides leach and runoff can cause human health problems including cancer tumors, reproduction deformity, disruption of the endocrine system and DNA damage. This application presents a sensitive and robust liquid chromatography method to test nine widely used herbicides (Figure 1), using a 3 µm UHPLC column to achieve very high throughput at a low flow rate to reduce testing time and solvent consumption. The throughput is compared to that of a conventional C18 HPLC column. Method conditions and performance data including precision and linearity, are presented.