The DSC 8500 is a double-furnace DSC, featuring our second-generation HyperDSC technology. Now you can gain unlimited insight into the structure, properties and performance of your materials.
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|21 CFR Part 11 Compatible||Yes|
|Maximum Temperature||750 °C|
|Minimum Temperature||-180 °C|
|Technology Type||Thermal Analysis|
This application note demonstrates the use of the Double Furnace DSC for the better and more complete characterization of hot melt adhesives.
Many materials have complex molecular structures that areable to exist in more than one crystalline form, a phenomenontermed polymorphism. Different forms may have differentproperties and, for pharmaceutical use, it is important tobe able to produce a pure and stable crystalline form of any material to be used as a drug compound. Using a Differential Scanning Calorimeter (DSC), different forms of such materials may be identified from their melting profiles and differing melting points.
Many polymers are semi-crystalline material. The percentage of crystallinity depends on many factors including chemical structure; interaction between polymer chains and processing conditions.
Differential scanning calorimetry (DSC) is commonly used to analyze foods in both quality control and research labs. DSC is often used to compare materials on heating, but cooling studies often give more information as materials can respond more thermodynamically under controlled cooling.
When an aluminum alloy is solution annealed andafterwards cooled too slowly, an exothermal precipitationreaction occurs. With increasing cooling rate, theprecipitation heat decreases. Since the precipitation reaction is relatively fast, a fast cooling rate on the differential scanning calorimeter (DSC) is essential to obtain the critical cooling rate which is the minimum cooling rate at which no precipitation heat is detectable. In this case, it was determined to be 375 (±10) K/min. Such a fast cooling rate can be realized through PerkinElmer’s HyperDSC® technology.
Differential scanning calorimetry (DSC) is a commonly used technique for studying polymeric; pharmaceutical; and energetic; materials. When considering which type of DSC to use to perform a specified measurement one typically chooses either a Power Compensation, or heat flux design.
Many pharmaceutical materials exhibit polymorphism, which means that, depending upon the given processing conditions, the crystalline form may exist in two or more states. The crystalline states or forms exhibit different levels of thermodynamic stabilities and an unstable form can melt at a temperature significantly less than the melting point of the thermodynamically stable form. Depending upon the conditions used to generate the crystalline form(s), the drug may exhibit one or more unstable, polymorphic crystalline states.
The concept of High-Throughput Design has gained more and more interest as a way to increase profitability and to decrease research costs. One technique that can increase the ability of a laboratory to evaluate formulations is HyperDSC™ or High Ramping Rate DSC. HyperDSC is the ability to quantitatively measure small samples at extreme heating and cooling rates, typically 100-500 °C/min.
Therefore, it is a sensitive test and can be used to show the difference between various batches of material, which may show little difference under a conventional heating experiment. Batches with different crystallization behavior will lead to variation in the quality of the final processed product. For polymer resin manufacture, it can be used for, quality assurance purposes, the optimization of resin formula or the evaluation of a competitor’s resin.
In designed formulations for lyophilized drugs, it is important to know the collapse temperature of the cake. If the, collapse temperature is exceeded, the cake will collapse and the batch will be ruined. The collapse temperature is often associated with the Tg’ of the frozen material and measuring this transition is the best way to approximate it.
DSC and Raman spectroscopy are both used to investigate crystallinity but in rather different ways. DSC can determine the degree of crystallinity very precisely and can also follow the kinetics of crystallization by measuring the associated enthalpy changes.
DSC and Raman spectroscopy are complementary techniques that are often applied to the same problems, principally to study phase transitions in solids. PerkinElmer’s state-of-the-art double-furnace DSC is heavily used in material characterization.
This note describes a number of important food applications utilising the PerkinElmer DSC demonstrating the versatility of the technique as a tool in the food industry.
StepScan DSC is a temperature modulated,DSC technique that operates in conjunction,with the Power Compensation Diamond,DSC from PerkinElmer. The approach,applies a series of short interval heating,and isothermal hold steps to cover the temperature range of interest. With the,StepScan™ DSC approach, two signals are obtained: the Thermodynamic Cp,signal represents the thermodynamic aspects of the material, while the Iso K,signal reflects the kinetic nature of the sample during heating. The following,basic equation mathematically describes the StepScan DSC approach:
Heat capacity measurement has been performed in order to detect a possible second Tg on nanocomposites of polymethyl methacrylate (PMMA) with silicon oxide nanoparticles of different shape. StepScan™ DSC was used for determination of precise heat capacity and HyperDSC® to prevent degradation and identify devitrification of the RAF at elevated temperatures.
The UV curing of resins is important in materials science. Direct energy measurement and true isothermal operation are essential to a successful UV curing experiment. Since the UV curing reaction is fast, a fast response DSC is needed to capture the process. The double-furnace power-controlled DSC 8000/8500 with UV accessory is the ideal tool to study the UV curing process and to characterize the material properties before and after the UV curing.
D-Mannitol is a common excipient used in the pharmaceutical formulation of tablets. It is often desirable to process the formula into an amorphous glassy state to improve some physical biological properties of the drug.
Truly comprehensive, our DSC portfolio of applications, instruments and services, combined with our expertise in materials characterization, can help you push the edge of science.
As the demand for solar power continues to grow, there needs to be a clear focus on different key issues in the life cycle of a solar cell. These issues are: efficiency, durability and cost. Coupling PerkinElmer’s application knowledge and experience together with our product portfolio, we can help manufacturers overcome these obstacles. At PerkinElmer, we’re taking action to ensure the quality of our environment.
The differential scanning calorimeter (DSC) is a fundamental tool in thermal analysis. It can be used in many industries - from pharmaceuticals to polymers and from nanomaterials to food products. The information these instruments generate is used to understand amorphous and crystalline behavior, polymorph and eutectric transitions, curing and degree of cure, and many other material properties used to design, manufacture and test products.
Product Note, Thermal Analysis, Polymenr Recycling Pack, Polyethylene Terephthalate, PET, polyethylene, PE, Polycarbonate, PC, Polystyrene, PS, Spectrum Two, Fourier Transform Infrared, FT-IR, Universal Attenuated Total Relectance, UATR, High Density Polyethylene, HDPE, Low Density Polyethylene LDPE, Differential Scanning Calorimetry, DSC, Thermogravimetric Analysis, TGA, Thermal Analysis
Product Note, Thermal, Differential Scanning Calorimetry, HyperDSC, UV, Visible, UV/Vis, UV Vis, DSC 8000, DSC 8500, 8000/8500
Modulated Temperature Differential Scanning Calorimetry (MTDSC) is a capability for determining from a single, multi-step DSC method both the specific heat capacity and the heat flow data drom a kinetically controlled process (e.g., reaction or crystallization). PerkinElmer provides this capability with its StepScan software, which is also especially suggested for high accuracy specific heat capacity (Cp) measurement.
Modulated Temperature Differential Scanning Calorimetry, MTDSC, Single and Multi-Step DSC Methods, StepScan, DSC 8500, DSC 8000, Modulated DSC, sinusoidal, Diamond DSC, Pyris 1, SmartScan
A simple experiment is suggested to demonstrate the response time of a DSC and to show how much time is needed for equilibration.
A calorimeter is a device that measures the heat exchange of a sample with its environment. Since heat is usually generated or consumed during a physical transition or chemical reaction; calorimetry is a universal tool to study such processes.
High throughput is a common concern for manufacturing environments. Recently, it has grown in importance for today’s busy research and analytical laboratories as well. Automation can be key to increasing a laboratory’s capabilities while freeing an analyst’s time for other work.
Differential Scanning Calorimetry, DSC, Simultaneious Thermal Analyzers, STA, Thermomechanical Analyzers, TMA, Cooking Accessories, Chillers, Refridgerated Coolers, LN2 Systems, non-cfc, non-chlorofluorocarbon, liquid nitrogen, portable cooling device, cryofill.