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The DSC 8500 is a double-furnace DSC, featuring our second-generation HyperDSC technology. Now you can gain unlimited insight into the structure, properties and performance of your materials.

Part Number N5340501
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Detail Information

  • Extremely fast controlled scanning rates to 750ºC/min
  • In-situ ballistic cooling to 2100ºC/min, enabling experiments that mimic real-world processes
  • Extremely fast data readout rates (100 points/second) providing high data integrity
Typical applications for the DSC 8500:
  • Characterization of pharmaceutical materials
  • Polymorph characterization in pharmaceuticals
  • Process studies in pharmaceuticals
  • Process simulation in plastics


21 CFR Part 11 Compatible Yes
Maximum Temperature 750 °C
Minimum Temperature -180 °C
Portable No
Technology Type Thermal Analysis
Warranty 1 year
Resources, Events & More
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Application Note

Better Characterization of Hot Melt Adhesives Using the Double Furnace DSC

This application note demonstrates the use of the Double Furnace DSC for the better and more complete characterization of hot melt adhesives.

PDF 822 KB
Confirming Polymorphic Purity with HyperDSC

Many materials have complex molecular structures that areable to exist in more than one crystalline form, a phenomenontermed polymorphism. Different forms may have differentproperties and, for pharmaceutical use, it is important tobe able to produce a pure and stable crystalline form of any material to be used as a drug compound. Using a Differential Scanning Calorimeter (DSC), different forms of such materials may be identified from their melting profiles and differing melting points.

PDF 335 KB
Detecting Weak Glass Transition (Tg) in Polymers by HyperDSC

Many polymers are semi-crystalline material. The percentage of crystallinity depends on many factors including chemical structure; interaction between polymer chains and processing conditions.

PDF 475 KB
Detecting the Adulteration of Extra Virgin Olive Oil by Controlled Cooling DSC

Differential scanning calorimetry (DSC) is commonly used to analyze foods in both quality control and research labs. DSC is often used to compare materials on heating, but cooling studies often give more information as materials can respond more thermodynamically under controlled cooling.

Determination of Critical Cooling Rate for Hardening Aluminum Alloys using HyperDSC

When an aluminum alloy is solution annealed andafterwards cooled too slowly, an exothermal precipitationreaction occurs. With increasing cooling rate, theprecipitation heat decreases. Since the precipitation reaction is relatively fast, a fast cooling rate on the differential scanning calorimeter (DSC) is essential to obtain the critical cooling rate which is the minimum cooling rate at which no precipitation heat is detectable. In this case, it was determined to be 375 (±10) K/min. Such a fast cooling rate can be realized through PerkinElmer’s HyperDSC® technology.

Differential Scanning Calorimetry Performance Comparison

Differential scanning calorimetry (DSC) is a commonly used technique for studying polymeric; pharmaceutical; and energetic; materials. When considering which type of DSC to use to perform a specified measurement one typically chooses either a Power Compensation, or heat flux design.

PDF 541 KB
High Resolution Characterization of Pharmaceutical Polymorphs Using Power Compensation DSC

Many pharmaceutical materials exhibit polymorphism, which means that, depending upon the given processing conditions, the crystalline form may exist in two or more states. The crystalline states or forms exhibit different levels of thermodynamic stabilities and an unstable form can melt at a temperature significantly less than the melting point of the thermodynamically stable form. Depending upon the conditions used to generate the crystalline form(s), the drug may exhibit one or more unstable, polymorphic crystalline states.

PDF 562 KB
HyperDSC for High Throughput Formulation Development

The concept of High-Throughput Design has gained more and more interest as a way to increase profitability and to decrease research costs. One technique that can increase the ability of a laboratory to evaluate formulations is HyperDSC™ or High Ramping Rate DSC. HyperDSC is the ability to quantitatively measure small samples at extreme heating and cooling rates, typically 100-500 °C/min.

PDF 720 KB
Isothermal Crystallization Study for Quality Assurance

Therefore, it is a sensitive test and can be used to show the difference between various batches of material, which may show little difference under a conventional heating experiment. Batches with different crystallization behavior will lead to variation in the quality of the final processed product. For polymer resin manufacture, it can be used for, quality assurance purposes, the optimization of resin formula or the evaluation of a competitor’s resin.

PDF 666 KB
Measurement of the Tg' in Formulations

In designed formulations for lyophilized drugs, it is important to know the collapse temperature of the cake. If the, collapse temperature is exceeded, the cake will collapse and the batch will be ruined. The collapse temperature is often associated with the Tg’ of the frozen material and measuring this transition is the best way to approximate it.

PDF 349 KB
Polymer Crystallinity Studies by DSC - Raman Spectroscopy

DSC and Raman spectroscopy are both used to investigate crystallinity but in rather different ways. DSC can determine the degree of crystallinity very precisely and can also follow the kinetics of crystallization by measuring the associated enthalpy changes.

PDF 350 KB
Polymorphism in Acetaminophen Studied by Simultaneous DSC and Raman Spectroscopy

DSC and Raman spectroscopy are complementary techniques that are often applied to the same problems, principally to study phase transitions in solids. PerkinElmer’s state-of-the-art double-furnace DSC is heavily used in material characterization.

PDF 391 KB
Practical Food Applications of Differential Scanning Calorimetry (Dsc)

This note describes a number of important food applications utilising the PerkinElmer DSC demonstrating the versatility of the technique as a tool in the food industry.

PDF 765 KB
StepScan DSC for Obscured Transitions

StepScan DSC is a temperature modulated,DSC technique that operates in conjunction,with the Power Compensation Diamond,DSC from PerkinElmer. The approach,applies a series of short interval heating,and isothermal hold steps to cover the temperature range of interest. With the,StepScan™ DSC approach, two signals are obtained: the Thermodynamic Cp,signal represents the thermodynamic aspects of the material, while the Iso K,signal reflects the kinetic nature of the sample during heating. The following,basic equation mathematically describes the StepScan DSC approach:

PDF 822 KB
Study Rigid Amorphous Fraction in Polymer Nano-Composites by StepScan and HyperDSC

Heat capacity measurement has been performed in order to detect a possible second Tg on nanocomposites of polymethyl methacrylate (PMMA) with silicon oxide nanoparticles of different shape. StepScan™ DSC was used for determination of precise heat capacity and HyperDSC® to prevent degradation and identify devitrification of the RAF at elevated temperatures.

PDF 949 KB
UV-DSC Study on New Double Furnace DSC

The UV curing of resins is important in materials science. Direct energy measurement and true isothermal operation are essential to a successful UV curing experiment. Since the UV curing reaction is fast, a fast response DSC is needed to capture the process. The double-furnace power-controlled DSC 8000/8500 with UV accessory is the ideal tool to study the UV curing process and to characterize the material properties before and after the UV curing.

PDF 934 KB


Characterization of D-Mannitol by Thermal Ananlysis, FTIR, and Raman Spectroscopy

D-Mannitol is a common excipient used in the pharmaceutical formulation of tablets. It is often desirable to process the formula into an amorphous glassy state to improve some physical biological properties of the drug.

PDF 487 KB


DSC Family Brochure

Truly comprehensive, our DSC portfolio of applications, instruments and services, combined with our expertise in materials characterization, can help you push the edge of science.

The Power of the Sun, Solar Energy Development Solutions

As the demand for solar power continues to grow, there needs to be a clear focus on different key issues in the life cycle of a solar cell. These issues are: efficiency, durability and cost. Coupling PerkinElmer’s application knowledge and experience together with our product portfolio, we can help manufacturers overcome these obstacles. At PerkinElmer, we’re taking action to ensure the quality of our environment.



Differential Scanning Calorimetry (DSC) Frequently Asked Questions

The differential scanning calorimeter (DSC) is a fundamental tool in thermal analysis. It can be used in many industries - from pharmaceuticals to polymers and from nanomaterials to food products. The information these instruments generate is used to understand amorphous and crystalline behavior, polymorph and eutectric transitions, curing and degree of cure, and many other material properties used to design, manufacture and test products.


Product Information Bulletin

Product Note

Polymer Recycling Pack

Product Note, Thermal Analysis, Polymenr Recycling Pack, Polyethylene Terephthalate, PET, polyethylene, PE, Polycarbonate, PC, Polystyrene, PS, Spectrum Two, Fourier Transform Infrared, FT-IR, Universal Attenuated Total Relectance, UATR, High Density Polyethylene, HDPE, Low Density Polyethylene LDPE, Differential Scanning Calorimetry, DSC, Thermogravimetric Analysis, TGA, Thermal Analysis

PDF 554 KB
UV/DSC Study on New Double Furnace DSC

Product Note, Thermal, Differential Scanning Calorimetry, HyperDSC, UV, Visible, UV/Vis, UV Vis, DSC 8000, DSC 8500, 8000/8500

PDF 964 KB

Regulatory Compliance Certification

Technical Note

DSC 8000 Equilibration

Modulated Temperature Differential Scanning Calorimetry (MTDSC) is a capability for determining from a single, multi-step DSC method both the specific heat capacity and the heat flow data drom a kinetically controlled process (e.g., reaction or crystallization). PerkinElmer provides this capability with its StepScan software, which is also especially suggested for high accuracy specific heat capacity (Cp) measurement.

Modulated Temperature DSC and DSC 8500: A Step Up in Performance

Modulated Temperature Differential Scanning Calorimetry, MTDSC, Single and Multi-Step DSC Methods, StepScan, DSC 8500, DSC 8000, Modulated DSC, sinusoidal, Diamond DSC, Pyris 1, SmartScan

New Design Improvements of the DSC 8000/8500 Double-Furnace Differential Scanning Calorimeter

A simple experiment is suggested to demonstrate the response time of a DSC and to show how much time is needed for equilibration.

PDF 659 KB
New Design Improvements of the DSC 8000/8500 Double-Furnace Differential Scanning Calorimeter

A calorimeter is a device that measures the heat exchange of a sample with its environment. Since heat is usually generated or consumed during a physical transition or chemical reaction; calorimetry is a universal tool to study such processes.

PDF 453 KB
The New Optima Family Computer-Controlled Solid-State RF Power Supply

High throughput is a common concern for manufacturing environments. Recently, it has grown in importance for today’s busy research and analytical laboratories as well. Automation can be key to increasing a laboratory’s capabilities while freeing an analyst’s time for other work.

Thermal Cooling Accesories

Differential Scanning Calorimetry, DSC, Simultaneious Thermal Analyzers, STA, Thermomechanical Analyzers, TMA, Cooking Accessories, Chillers, Refridgerated Coolers, LN2 Systems, non-cfc, non-chlorofluorocarbon, liquid nitrogen, portable cooling device, cryofill.

PDF 483 KB

White Paper

White Paper - Mercedes GP Petronas Formula One Team Racing to the Championship With PerkinElmer

The Fédération Internationale de l’Automobile (FIA) Sporting Regulations requires that gearboxes must be used on the race car for four races. This ruling places a direct emphasis upon the requirement for a method of periodically analyzing the gearbox for an indication of deterioration.