Collection of LC App Brief Notes in Accordance to the United States Pharmacopoeia (USP) Methods
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Application Note

Collection of LC App Brief Notes in Accordance to the United States Pharmacopeia (USP) Methods

Introduction

The official requirements for Pharmacopeia can be found in the general notices, individual monographs, and general tests and assays chapters. Monographs contain tests, procedures, and criteria to ensure the identity, strength, quality, and purity of the active pharmaceutical ingredient (API) and drug product.

This collection of app brief notes demonstrates the use of our Epic C18 HPLC Columns fulfilling all the requirements described in the monographs for the top generic medicines approved by FDA.

HPLC Analysis of Betamethasone Dipropionate Using Epic C18 HPLC Column

Betamethasone dipropionate is classified as a ‘super-potent’ steroid in the treatment of psoriasis in comparison with betamethasone valerate (another common analogue of betamethasone) which is rated as upper mid-strength. This application brief describes the use of an Epic C18 column for the analysis of betamethasone dipropionate in accordance with the official USP monograph.

HPLC Analysis of Finasteride Using an Epic C18 HPLC Column

Finasteride is commonly sold under the brand name Proscar and in 2016 was the 75th most prescribed drug in the USA. This application brief describes the use of an Epic C18 column to analyze finasteride in accordance with the official Finasteride Tablets USP monograph.

HPLC Analysis of Amlodipine Besylate in Accordance with the USP

Amlodipine is listed on the World Health Organization’s (WHO) list of essential medicines as an antihypertensive medicine, meaning that it considered among the safest and most effective compounds needed to meet the requirements of a basic healthcare system. This application brief describes the use of our Epic C18 column to analyze amlodipine besylate in accordance with the official USP monograph.

HPLC Analysis of the Semi-Synthetic Antibiotic Azithromycin Using an Epic C18 Column

The mode of action of azithromycin is like other macrolide antibiotics, it inhibits bacterial protein synthesis by binding to and interfering with the assembly of the 50S large ribosomal subunit of the bacteria, thereby inhibiting translation of mRNA. This application brief describes the use of an Epic C18 column for the simple analysis of azithromycin.