3D Cell Culture & Analysis

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3D cell cultures, microtissues, and organoids are increasingly being used to bridge the gap between 2D cell cultures and in vivo animal models. 3D cell models are more physiologically relevant than biochemical assays and 2D cell cultures, as they more closely represent the microenvironments, cell-to-cell interactions, and biological processes that occur in vivo. 3D cell models show a higher degree of morphological and functional differentiation – again, similar to in vivo cell characteristics.

Grow, detect, and analyze 3D cell cultures with our best-in-class solutions, and begin generating more physiologically relevant data that can power better-informed decisions.

Grow 3D cell culture with speciality microplates

Our CellCarrier Spheroid ULA microplates enable the use of three-dimensional (3D) cell culture models for cell-based microplate assays. The unique Ultra-Low Attachment (ULA) surface promotes the formation of consistently round spheroids. The optically-clear, round bottom wells produces high-quality imaging results.

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CellCarrier Spheroid ULA 96-well Microplates, pack of 10

Detect with sensitive detection and high-content imaging solutions

Our multimode microplate readers and high-content analysis systems, plus innovative reagents, provide you with highly sensitive solutions for 3D cell culture imaging and detection.

Opera Phenix™ high-content screening system is the premier confocal solution for 3D high-content screening, enabling fast multichannel 3D acquisition at high image quality.
With its unique combination of technologies, the Operetta CLS™ high-content analysis system provides flexibility, sensitivity, and resolution for 3D imaging.
With the EnSight multimode plate reader you can monitor the growth and health of your 3D cell cultures by measuring size, shape, and more using image cytometry. Combine imaging with other technologies such as AlphaLISA® to detect secreted proteins.
ATPlite™ 3D and ATPlite 1step 3D reagent kits for cell viability and proliferation provide a simple, robust protocol for ATP-content endpoint measurements of 3D spheroids.

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PreciScan Intelligent Acquisition ATPlite 3D, 300 assay point kit EnSight Multimode Plate Reader Operetta CLS High-Content Analysis System Opera Phenix High-Content Screening System

Analyze with powerful and intuitive informatics solutions to uncover new insights

Our scientific software and informatics solutions give you the tools to optimize imaging of 3D cell models and then aggregate, search, mine, and visualize critical data - and turn it into actionable insights.

Turn data into understanding with the intuitive Harmony™ imaging and analysis software for the Opera Phenix and Operetta CLS systems. You can accelerate 3D image acquisition and analysis, better understand spatial relationships, discover new perspectives not visible in 2D and measure volume and morphology in 3D. Optional PreciScan™ intelligent acquisition lets you pre-scan to locate your sample in the well for significantly reduced acquisition and analysis times.
Manage the large amounts of data that high-content analysis generates with Columbus™ image data storage and analysis software. Add cluster computing capabilities for even greater power when acquiring large datasets for working with 3D samples.

Suggested Products

Columbus Image Data Storage and Analysis System

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Clearing Strategies for 3D Spheroids 3D Volumetric and Zonal Analysis of Solid Spheroids 5 Top Tips for a Successful High-content Screening Assay with a 3D Cell Model System 3D Cell Culture Solutions Brochure Seeing Cell Culture in 3D Imaging Bile Canaliculi in 3D Liver Microtissues Quantitative Analysis of 3D Microtissue Growth and Biomarker Intensity

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Operetta CLS High-Content Analysis System

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Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS^™ high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS^™ lets you find even subtle phenotypic changes.
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Opera Phenix High-Content Screening System

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The Opera Phenix^™ High Content Screening System is the premier confocal solution for today's most demanding high content applications. Drawing on over a decade of experience with the industry-leading Opera^® High Content Screening System, the Opera Phenix is designed for high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells and microtissues.
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EnSight Multimode Plate Reader

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The EnSight^™ multimode plate reader offers HTS Alpha, Ultra-sensitive Luminescence and fast well-imaging technologies alongside conventional multimode detection technologies. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido^™ data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.
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ATPlite 1Step 3D, 10 mL kit

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ATP-monitoring luminescence assay for quantitative evaluation of proliferation and cytotoxicity of mammalian cells cultured in 3D spheroids. The 1-step format only requires one addition step, and can be used for continuous processing.
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ATPlite 3D, 300 assay point kit

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ATP-monitoring luminescence assay for quantitative evaluation of proliferation and cytotoxicity of mammalian cells cultured in 3D spheroids.
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CellCarrier Spheroid ULA 96-well Microplates

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Round bottom, clear 96-well polystyrene microplates coated with Ultra Low Attachment (ULA) surface for 3D culture of mammalian cells. This ULA coating in round-bottom wells facilitates formation of round spheroids after incubating seeded cells.
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Columbus Image Data Storage and Analysis System

ColumbusPlus , Columbus

Our Columbus^™ Image Data Storage and Analysis system is an instrument agnostic image analysis and management platform. The Columbus system is the only system that provides universal high-volume image data storage and analysis and brings access to images from a wide range of sources including all major high content screening instruments.
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Harmony High-Content Imaging and Analysis Software

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Easily quantify complex cellular phenotypes with Harmony^® high-content analysis software. Harmony software is designed for PerkinElmer high-content screening systems.
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PreciScan Intelligent Acquisition

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Harness the power of intelligent image acquisition with PreciScan for more efficient high-content imaging and analysis. This optional plug-in for Harmony high-content analysis software enables you to more accurately target your object of interest for significantly reduced acquisition and analysis times, particularly valuable for 3D microtissue and rare event studies.