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DNA-PK, a nuclear DNA-dependent serine/threonine protein kinase, consists of two components, a DNA-dependent protein kinase, catalytic subunit (DNA PKcs) and an autoimmune antigen (KU). DNA-PKcs is inactive and relies on KU to direct it to DNA ends and trigger kinase activity where it is required for the non-homologous end joining pathway of DNA repair which rejoins double-strand breaks. DNA repair genes likely underlie many forms of cancer, and reduced expression of DNA PKcs is associated with cancers such as breast, prostate, and gastric.
The AlphaLISA SureFire Human Phospho-DNA PKcs (Ser2056) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-DNA PKcs (Ser2056) in cellular lysates, using Alpha Technology.
|Assay Points (200-50,000)||500 Assay Points|
|Assay Target||DNA PKcs|
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Unit Size||500 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...