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AngioSense® 750 EX is a fluorescent in vivo blood pool imaging agent. AngioSense® 750 EX is a near-infrared labeled fluorescent macromolecule that remains localized in the vasculature for extended periods of time and enables imaging of blood vessels and angiogenesis.,AngioSense® 750 EX can be used to study angiogenesis, as a marker for blood vessel density, in animal tumor models. AngioSense® 750 EX can be used to characterize vascular changes and therapeutic responses associated with animal models of arthritis.
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In vivo optical imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. In oncology, increases in tumor vascular permeability can be an early indicator of tumor angiogenesis. In inflammatory disease increased vascular permeability can indicate alterations in fluid homeostasis in an acute edema response or in chronic organ conditions.
PerkinElmer’s AngioSense® NIR fluorescent probes are designed to evaluate vascular changes to better understand various disease states or provide valuable information on effects of drug candidates earlier in the development process.