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Astemizole is known to be a potent blocker of the hERG (human ether-a-go-go-related gene) potassium ion channel. Astemizole, [O-Methyl-3H]- was developed as a radioligand for the hERG K+ channel binding assay. The radioligand binding assay of the hERG channel is used to identify compounds which may have potential cardiotoxicity.
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