1-6 of 6 Products & Services
This accessory allows the analysis of rabbit species in the Quantum line of microCT instruments.
Designed for use with PerkinElmer's IVIS® optical imaging systems, Living Image enables you to analyze 2D and 3D optical imaging data from your animal models with ease. With features such as wizard guidance for acquisition parameter setup and co-registration with other imaging modalities, Living Image allows you to seamlessly capture, visualize and analyze your 2D or 3D optical data to facilitate your drug discovery & development and biology research.
Living Image in vivo software is available for the IVIS Lumina and IVIS Spectrum Series.
1-3 of 3 Resource Library
Blood vessel mechanics and function are important aspects of cardiovascular research. Arterial changes have been associated with several pathophysiological conditions, disease states and treatment. Structural components of the arterial vessel wall, smooth vasculature tone, and transmural distending pressure are the primary determinants of vascular wall mechanical properties.
Pulmonary Arterial Hypertension (PAH) is a life-threatening disease that affects the arteries in the lungs and the right side of the heart. It is characterized by an increase in pulmonary arterial pressure leading to right ventricular (RV) hypertrophy, heart failure, and death.
Small animal models are often used in experimental PAH research due to their similarities to human cardiovascular physiology. MRI and Ultrasound are established tools in evaluating RV function and physiology but each can present certain challenges including complex acquisition techniques, long imaging times, high imaging costs and accessibility. Conversely, microCT offers superior special resolution, fast acquisition times, 4D imaging, and ease-of-use.
Read this application note highlighting how researchers used the Quantum GX microCT system to quantify distensibility measurements in a rodent model using contrast-enhanced retrospectively gated computed tomography imaging.
X-ray CT imaging is commonly used for skeletal imaging as bones are densely mineralized tissues with excellent x-ray attenuation properties. In contrast, soft, less dense tissues often prove to be challenging to image due to their lack of sufficient tissue density. Soft tissues such as muscle, blood vessels and internal organs share similar x-ray attenuation characteristics and are not distinguishable under typical CT settings. In order to introduce density that would improve soft tissue contrast, several contrast agents have been developed for use in clinical and preclinical settings. This application note outlines the use of iodine and nanoparticle-based contrast agents for imaging soft tissues and vasculature in various organs using the Quantum GX to gain further insights into disease and therapeutic response.
Osteoarthritis (OA) is the most common form of arthritis and affects a considerable portion of the elderly population. In the U.S., it is estimated that more than 630 million people worldwide have this chronic condition, generally in the knees. OA occurs when the cartilage that cushions the ends of bones within the joints gradually deteriorates, causing synovitis and joint deformation.
The goal of OA research is to identify new therapeutic strategies that could prevent, reduce, halt progression, or repair the existing damage to the joint. Non-invasive in vivo imaging such as microCT is the standard modality for bone research due to its ability to obtain high-resolution images at an x-ray dose low enough as not to harm the animal. This makes microCT ideal for monitoring disease progression and response to treatments in the same animal over time. However, microCT data visualization and analysis can be cumbersome and time consuming. In this application note, we compared standard microCT software and advanced bone software to investigate bone erosion in an OA rat model.