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Search Results for 'IVIS'

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1-22 of 22 Products & Services

  • IVIS Lumina S5 high throughput, high sensitivity optical in vivo imaging system

    IVIS® Lumina S5 Imaging System

    The IVIS® Lumina S5 high-throughput 2D optical imaging system combines high-sensitivity bioluminescence and fluorescence in a benchtop format. With an expanded 5 mouse field of view for 2D optical imaging plus our unique line of accessories to accelerate setup and labeling, it has never been easier or faster to get robust data—and answers—on anatomical and molecular aspects of disease.
  • IVIS-SpectrumCT-Hero

    IVIS® SpectrumCT In Vivo Imaging System

    The IVIS® SpectrumCT preclinical in vivo imaging system expands upon the versatility of the IVIS Spectrum by offering 2D and 3D imaging capabilities but includes integrated low-dose microCT ideal for longitudinal studies. The system provides researchers with greater insights into complex biological systems by enabling simultaneous molecular and anatomical non-invasive imaging in animal models.
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS® Lumina LT In Vivo Imaging System

    The IVIS® Lumina LT Series III pre-clinical in vivo imaging system offers the industries most sensitive benchtop platform at an entry level price.
  • IVIS Lumina X5 in vivo imaging system

    IVIS® Lumina X5 Imaging System

    High-Sensitivity Optical Meets High-Resolution X-ray

    The IVIS® Lumina X5 high-throughput 2D optical imaging system combines high-sensitivity bioluminescence and fluorescence with high-resolution x-ray into a compact system that fits on your benchtop. With an expanded 5 mouse field of view for 2D optical imaging plus our unique line of accessories to accelerate setup and labeling, it has never been easier or faster to get robust data—and answers—on anatomical and molecular aspects of disease.
  • SpectrumBL-CU-Hero

    IVIS® SpectrumBL High-Throughput In Vivo Optical Imaging System

    The IVIS® SpectrumBL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of bioluminescent, chemiluminescent and Cerenkov in vivo imaging.
  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS In Vivo Imaging System

    Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.
  • Spectrum-CU-Hero

    IVIS Spectrum In Vivo Imaging System

    The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclinical imaging research and development ideal for non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS® Lumina III In Vivo Imaging System

    The IVIS® Lumina Series III brings together years of leading optical imaging technologies into one easy to use and exquisitely sensitive bench-top system.
  • XNC?-2 Mouse Nose Cones

    XNC-2 Mouse Nose Cones, set of 10

    These transparent glass nose cones are low luminescent and low fluorescent. They are for use with the XGI-8 Anesthesia System and 5-port anesthesia system manifold.
    List Price : 596.00 USD
  • SMT-5 Smart Mouse Tray

    SMT-5 Smart Mouse Tray (IVIS Lumina S5 & IVIS Lumina X5)

    SMT-5 Smart Mouse Imaging Tray for use with the IVIS® Lumina S5 and IVIS Lumina X5 in vivo imaging systems, allows benchtop posing of 5 animals when used in conjunction with the Benchtop Posing Station (sold separately). Bed is easily transferable from the benchtop to the IVIS imaging system with quick connect anesthesia functionality. A robust new manifold design requires no nose cones and offers superior scavenging for reduced anesthesia gas exposure. Incorporated fiducials facilitate auto subject recognition by the Living Image® Software. Includes mouse and rat dividers for signal isolation of optical probes. Provides the ultimate in flexibility and convenience to streamline your imaging workflow.
    List Price : 5800.00 USD
  • Syringe Injection System (IVIS Lumina Series III systems and Spectrum CT)

    This syringe injection system enables users to image while simultaneously inject compounds into mice. The system is used for use with Lumina Systems or SpectrumCT systems.
    List Price : 10900.00 USD
  • InVivo-University

    In Vivo University

    To ensure you benefit fully from the capabilities of our IVIS® imaging platforms, we offer classroom courses including hands on training though In Vivo University at our Center of Excellence in Hopkinton, MA.
  • Mice imaging using IVIS Lumina and Living Image Software

    Living Image Software

    Designed for use with PerkinElmer's IVIS® optical imaging systems, Living Image enables you to analyze 2D and 3D optical imaging data from your animal models with ease. With features such as wizard guidance for acquisition parameter setup and co-registration with other imaging modalities, Living Image allows you to seamlessly capture, visualize and analyze your 2D or 3D optical data to facilitate your drug discovery & development and biology research.

    Living Image in vivo software is available for the IVIS Lumina and IVIS Spectrum Series.

  • XIC-3 Animal Isolation Chamber Kit

    This chamber provides biological isolation of anesthetized mice or small rats before they are imaged in an in vivo imaging system.
  • Fluorescence phantom mouse for use with IVIS optical imaging systems

    XFM-2X Fluorescent Phantom Mouse (X-Ray)

    The XFM-2X Phantom Mouse is used for training and/or practice using IVIS optical imaging systems in fluorescence and/or x-ray mode. The outer material is made to mimic tissue properties so the user sees light scatter similar to what is seen in a live subject. The color of the surface of the phantom emulates the behavior of tissue background fluorescence (autofluorescence). The XFM-2 comes with various plastic rods containing different fluorescent dyes to simulate fluorescence imaging.
    List Price : 4309.00 USD
  • Bioluminescent phantom mouse for training purposes with IVIS optical imaging systems

    XPM-2 Bioluminescent Phantom Mouse

    The XPM-2 Phantom Mouse is used for training and/or practice using IVIS optical imaging systems in bioluminescence mode. Made of outer materials to mimic tissue, the XPM has LED lights inside the phantom at various locations to mimic bioluminescence signals.
    List Price : 4595.00 USD
  • VivoTrack-680 Fluorescent Labeling Kit - Standard Kit NEV12000

    VivoTrack 680 NIR Fluorescent Imaging Agent

    Label and track mammalian cells including stem cells, T-cells, macrophages and more with VivoTrack fluorescent labeling dye.

    VivoTrack 680 is an NIR fluorescent lipophilic dye that intercalates in the cell membrane. With high solubility and excellent stability, VivoTrack offers superior brightness and uniform labeling, ideal for cell detection in vitro and longitudinal cell tracking in vivo across many applications including inflammation, immunology, and stem cell research.

    Price Range : 123.00 USD - 310.00 USD
  • RediJect Inflammation Probe Explorer Kit

    XenoLight RediJect Inflammation Probe Kits

    XenoLight RediJect Inflammation probe is a chemiluminescent in vivo reagent for monitoring Inflammation. This probe is offered in a ready-to-use format and can be conveniently applied to study myeloperoxidase (MPO) activity of activated phagocytes.
    Price Range : 130.00 USD - 326.00 USD
  • XenoLight D-Luciferin Salt

    XenoLight D-Luciferin - K+ Salt Bioluminescent Substrate

    Luciferin is essential in performing your bioluminescent assays, and the quality of your research will depend on the quality of your luciferin. Whether used to perform in vitro assays, or to monitor light production in vivo, PerkinElmer’s high quality luciferin is available at an affordable price.
    Price Range : 288.00 USD - 2458.00 USD
  • VivoTag-S Fluorochrome - 1 mg quantity

    VivoTag Fluorescent Dyes

    Label antibodies, small molecules, proteins, or peptides with VivoTag® NIR fluorescent dyes.

    Available as either NHS esters or maleimide reactive dyes, making conjugation to either free amine (-NH3) or free thiol (-SH) containing molecules possible, our VivoTag fluorescent dyes have been validated for in vivo and in vitro applications. Please refer to the configuration table below to see which VivoTag fluorescent agent is best for your research studies.

    VivoTag is available in multiple sizes and wavelengths to fit your imaging needs.

    Price Range : 191.00 USD - 728.00 USD
  • XFOV-24 lens for Lumina II (any Lumina built after 2008)

    Upgradable expansion lens to 24 x 24 cm field of view for the IVIS Lumina II.
    List Price : 3884.00 USD
  • High Throughput Imaging Kit

    High Throughput Imaging Kit

    For use with the IVIS® Lumina S5 and X5 in vivo imaging systems, the High Throughput Imaging Kit contains all of the needed accessories to allow researchers to increase throughput and streamline imaging workflows.
    List Price : 17500.00 USD
Resource Library (206)
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1-13 of 13 Resource Library

  • Application Note

    Cell Labeling and Tracking In Vivo Using VivoTrack™ NIR Fluorescent Dye

    Fluorescent dyes have been used for many years to label cells for microscopy studies, and a variety of dyes in the visible fluorescence spectrum are available to label different cellular compartments and organelles. Efficient delivery of the fluorophore to the cell without excessively modifying surface proteins or perturbing cell function is the major biotechnological challenge.

    VivoTrack is a NIR fluorescent dye with a long aliphatic tail to facilitate insertion into the lipid bilayer of the cell. With high solubility, reactivity, and excellent stability, VivoTrack dye offers superior brightness ideal for detection and longitudinal cell tracking in vivo across many applications including inflammation, immunology, and stem cell research.

    This application note highlights the benefits of using VivoTrack NIR fluorescent dye in your in vivo imaging studies:

    • Track stem cells, T cells, macrophages and many other cell types longitudinally in vivo
    • Water soluble - no need for harsh organics such as DMSO or ethanol, chemicals known to affect cell function.
    • Homogeneous cell staining with no impact on cell viability
    • Optimized for in vivo use with PerkinElmer’s IVIS® optical imaging platform

  • Poster

    In vivo fluorescent imaging of tumor bombesin and transferrin receptor expression as early indicators of sorafenib efficacy in small animal models

    Targeted cancer therapy aims to block key signaling pathways that are critical for tumor cell growth and survival. The blockage eventually results in cell death via apoptosis and eventual tumor growth suppression. This strategy has proven to be quite effective, and the FDA has approved several targeted therapeutics in the past decade. Encouraged by the success in clinical development, many academic and pharmaceutical researchers are in active pursuit of improved next generation targeted anti-cancer drugs. As a result, many new chemical and biological entities are emerging from initial screening of in vitro, in vitro and/or in silico selection processes. From the perspective of drug development, it poses a great challenge for the next stage of in vivo validation and demands a robust, accurate, and efficient method for assessment of these candidates in living animal models.

  • Case Study

    A Novel Mouse Model Using Optical Imaging to Detect On-Target, Off-Tumor CART-T Cell Toxicity

    CAR T therapy has achieved tremendous success in treating blood malignancies, however treating solid tumors with this therapy has proven to be challenging due to several factors such as on-tumor, off-tumor toxicity.

    Read this case study where researchers from University of Pennsylvania created a mouse model that expresses tumor associated antigens in normal tissue to study off-tumor CART-T cell toxicity. These studies used optical imaging on the IVIS® platform to longitudinally monitor off-tumor antigen expression, tumor progression, and CAR-T cell trafficking in live animals.

  • Application Note

    Stem Cell Research and Regenerative Medicine

    With the potential to treat a wide range of disease, from organ damage to congenital defects, stem cell research and tissue engineering form the underlying basis of regenerative medicine. Significant advances in the science of skin regeneration, for example, have now made it possible to develop and grow artificial skin grafts in a lab for treatment of burn victims. Other therapeutic applications include the use of stem cells to treat and repair central nervous system diseases such as ischemia and cerebral palsy, cardiovascular diseases, as well as autoimmune diseases including type I diabetes.

  • Application Note

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • Technical Note

    Tips for removing background fluorescence in your in vivo imaging models

    In vivo optical imaging can provide information at the cellular biomarker level regarding disease states and therapeutic response. Bioluminescence imaging presents few challenges with respect to imaging and data acquisition. However, fluorescence imaging requires strategies to compensate for background fluorescence. Without proper background subtraction, results may underestimate biological changes or the magnitude of therapeutic efficacy of a drug. There are several contributors to background fluorescence which can vary depending on disease model and probe used all of which need to be considered when developing a mouse model for fluorescence imaging. Learn about key considerations for defining and applying background correction to improve fluorescence quantification and interpretation using the IVIS® platform in this technical note.

  • Poster

    Molecular imaging of tumor energy metabolism as an early indicator of anti-cancer drug efficacy in small animal models

    Targeted cancer therapy aims to block key signaling pathways that are critical for tumor cell growth and survival. The blockage eventually results in cell death via apoptosis and tumor growth suppression. Encouraged by the success in clinical development, many academic and pharmaceutical researcher are in active pursuit of the improvement of next generation targeted anti-cancer drugs. As a result, many new chemical and biological entities are emerging from initial screening of in vitro, in vitro and/or in silico selection processes. From the perspective of drug development, it poses a great challenge on the next stage of in vivo validation and demands a robust, accurate, and efficient method for assessment of these candidates in living animal models.

  • Application Note

    Quantitative Analysis of Bone Erosion Using High-Resolution X-Ray Imaging

    Bone erosion is a pathological condition characterized by breaks in the cortical bone surface and loss of the adjacent trabecular bone. Several pathological processes can lead to bone erosion, including malignant tumors, abnormal metabolic processes such as hyperparathyroidism, and chronic inflammatory diseases such as rheumatoid arthritis. In clinical settings, bone erosion is routinely detected using X-ray based imaging technologies such as computed tomography (CT). Although preclinical CT offers high resolution 3D imaging for bone, accessibility to this modality may be challenging. Learn how optical and high-resolution X-ray imaging capability on the IVIS Lumina X5 system and Living Image® software was used for obtaining high quality images for quantitative analysis in a mouse bone erosion model, with the ease and speed of 2D imaging.

  • Poster

    Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts

    Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more important to integrate safety/toxicology assessments earlier in the drug development process. There are a variety of traditional serum markers, tailored mechanistically to specific tissues, however there are no current non-invasive assessment tools that are capable of looking broadly at in situ biological changes in target and non-target tissue induced by chemical insult.

  • Case Study

    Using IVIS optical imaging of CRISPR/Cas9 engineered adipose tissue to study obesity prevention

    Obesity is a global epidemic that is the fifth leading cause of death worldwide and in the US alone, nearly 85% of adults are expected to be overweight or obese by 2030. In addition to the increased risk of overall mortality, obesity is associated with an increased risk for other metabolic disorders such as diabetes and heart disease which pose a significant burden to health care systems.

    Read this case study to learn how researchers at the Joslin Diabetes Center in Boston, Massachusetts used the IVIS® optical imaging system to visualize and quantify CRISPR/Cas9 engineered adipose tissue in a mouse model to study the prevention of obesity and obesity-related metabolic disorders.

  • Application Note

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • Application Note

    Application Spotlight: Cell and Gene Therapy

    The collection of app notes focuses on how we can quickly analyze cellular images through machine-assisted learning and characterize profile, and test for the efficacy of the delivery vehicle and transgene using our latest technologies.

  • Application Note

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.