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Search Results for 'IVIS'

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  • IVIS Lumina Series (1)
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1-19 of 19 Products & Services

  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS In Vivo Imaging System

    Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina III In Vivo Imaging System

    The IVIS® Lumina Series III brings together years of leading optical imaging technologies into one easy to use and exquisitely sensitive bench-top system.
  • Spectrum-CU-Hero

    IVIS Spectrum In Vivo Imaging System

    The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclinical imaging research and development ideal for non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.
  • IVIS Lumina X5 in vivo imaging system

    IVIS Lumina X5 Imaging System

    High-Sensitivity Optical Meets High-Resolution X-ray

    The IVIS® Lumina X5 high-throughput 2D optical imaging system combines high-sensitivity bioluminescence and fluorescence with high-resolution x-ray into a compact system that fits on your benchtop. With an expanded 5 mouse field of view for 2D optical imaging plus our unique line of accessories to accelerate setup and labeling, it has never been easier or faster to get robust data—and answers—on anatomical and molecular aspects of disease.
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina LT In Vivo Imaging System

    The IVIS® Lumina LT Series III pre-clinical in vivo imaging system offers the industries most sensitive benchtop platform at an entry level price.
  • IVIS-SpectrumCT-Hero

    IVIS SpectrumCT In Vivo Imaging System

    The IVIS® SpectumCT preclinical in vivo imaging system expands upon the versatility of the IVIS Spectrum by offering 2D and 3D imaging capabilities but includes integrated low-dose microCT ideal for longitudinal studies. The system provides researchers with greater insights into complex biological systems by enabling simultaneous molecular and anatomical non-invasive imaging in animal models.
  • SpectrumBL-CU-Hero

    IVIS SpectrumBL High-Throughput In Vivo Optical Imaging System

    The IVIS® SpectrumBL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of bioluminescent, chemiluminescent and Cerenkov in vivo imaging.
  • IVIS Lumina S5 high throughput, high sensitivity optical in vivo imaging system

    IVIS Lumina S5 Imaging System

    The IVIS® Lumina S5 high-throughput 2D optical imaging system combines high-sensitivity bioluminescence and fluorescence in a benchtop format. With an expanded 5 mouse field of view for 2D optical imaging plus our unique line of accessories to accelerate setup and labeling, it has never been easier or faster to get robust data—and answers—on anatomical and molecular aspects of disease.
  • XNC?-2 Mouse Nose Cones

    XNC-2 Mouse Nose Cones, set of 10

    These transparent glass nose cones are low luminescent and low fluorescent. They are for use with the XGI-8 Anesthesia System and 5-port anesthesia system manifold.
    List Price : 596.00 USD
  • Syringe Injection System (IVIS Lumina Series III systems and Spectrum CT)

    This syringe injection system enables users to image while simultaneously inject compounds into mice. The system is used for use with Lumina Systems or SpectrumCT systems.
    List Price : 10900.00 USD
  • InVivo-University

    In Vivo University

    To ensure you benefit fully from the capabilities of our IVIS® imaging platforms, we offer classroom courses including hands on training though In Vivo University at our Center of Excellence in Hopkinton, MA.
  • Mice imaging using IVIS Lumina and Living Image Software

    Living Image Software

    Designed for use with PerkinElmer's IVIS® optical imaging systems, Living Image enables you to analyze 2D and 3D optical imaging data from your animal models with ease. With features such as wizard guidance for acquisition parameter setup and co-registration with other imaging modalities, Living Image allows you to seamlessly capture, visualize and analyze your 2D or 3D optical data to facilitate your drug discovery & development and biology research.

    Living Image in vivo software is available for the IVIS Lumina and IVIS Spectrum Series.

  • XIC-3 Animal Isolation Chamber Kit

    This chamber provides biological isolation of anesthetized mice or small rats before they are imaged in an in vivo imaging system.
  • XenoLight D-Luciferin Salt

    XenoLight D-Luciferin - K+ Salt Bioluminescent Substrate

    Luciferin is essential in performing your bioluminescent assays, and the quality of your research will depend on the quality of your luciferin. Whether used to perform in vitro assays, or to monitor light production in vivo, PerkinElmer’s high quality luciferin is available at an affordable price.
    Price Range : 279.00 USD - 2377.00 USD
  • Mouse ID kit for automatic subject recognition and animal ID

    Mouse ID Kit

    The Mouse Imaging ID Kit for use with the IVIS® Lumina S5 and IVIS Lumina X5 imaging systems contains all of the tools needed to incorporate automatic subject recognition and animal identification into a standard imaging workflow.
    List Price : 9800.00 USD
  • High Throughput Imaging Kit

    High Throughput Imaging Kit

    For use with the IVIS® Lumina S5 and X5 in vivo imaging systems, the High Throughput Imaging Kit contains all of the needed accessories to allow researchers to increase throughput and streamline imaging workflows.
    List Price : 17500.00 USD
  • High Throughput Imaging & ID Kit

    High Throughput Imaging and ID Kit

    Increase imaging throughput and streamline in vivo imaging workflow on the IVIS® Lumina S5 and IVIS Lumina X5 with the High Throughput Imaging and ID Kit.
    List Price : 23100.00 USD
  • XFOV-24 lens for Lumina II (any Lumina built after 2008)

    Upgradable expansion lens to 24 x 24 cm field of view for the IVIS Lumina II.
    List Price : 3885.00 USD
  • SMT-5 Smart Mouse Tray

    SMT-5 Smart Mouse Tray

    SMT-5 Smart Mouse Imaging Tray for use with the IVIS® Lumina S5 and IVIS Lumina X5 in vivo imaging systems, allows benchtop posing of 5 animals when used in conjunction with the Benchtop Posing Station (sold separately). Bed is easily transferable from the benchtop to the IVIS imaging system with quick connect anesthesia functionality. A robust new manifold design requires no nose cones and offers superior scavenging for reduced anesthesia gas exposure. Incorporated fiducials facilitate auto subject recognition by the Living Image® Software. Includes mouse and rat dividers for signal isolation of optical probes. Provides the ultimate in flexibility and convenience to streamline your imaging workflow.
    List Price : 5800.00 USD
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1-9 of 9 Business Insights

  • Poster

    Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts

    Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more important to integrate safety/toxicology assessments earlier in the drug development process. There are a variety of traditional serum markers, tailored mechanistically to specific tissues, however there are no current non-invasive assessment tools that are capable of looking broadly at in situ biological changes in target and non-target tissue induced by chemical insult.

  • Poster

    In vivo fluorescent imaging of tumor bombesin and transferrin receptor expression as early indicators of sorafenib efficacy in small animal models

    Targeted cancer therapy aims to block key signaling pathways that are critical for tumor cell growth and survival. The blockage eventually results in cell death via apoptosis and eventual tumor growth suppression. This strategy has proven to be quite effective, and the FDA has approved several targeted therapeutics in the past decade. Encouraged by the success in clinical development, many academic and pharmaceutical researchers are in active pursuit of improved next generation targeted anti-cancer drugs. As a result, many new chemical and biological entities are emerging from initial screening of in vitro, in vitro and/or in silico selection processes. From the perspective of drug development, it poses a great challenge for the next stage of in vivo validation and demands a robust, accurate, and efficient method for assessment of these candidates in living animal models.

  • Application Note

    Stem Cell Research and Regenerative Medicine

    With the potential to treat a wide range of disease, from organ damage to congenital defects, stem cell research and tissue engineering form the underlying basis of regenerative medicine. Significant advances in the science of skin regeneration, for example, have now made it possible to develop and grow artificial skin grafts in a lab for treatment of burn victims. Other therapeutic applications include the use of stem cells to treat and repair central nervous system diseases such as ischemia and cerebral palsy, cardiovascular diseases, as well as autoimmune diseases including type I diabetes.

  • Application Note

    Quantitative Analysis of Bone Erosion Using High-Resolution X-Ray Imaging

    Bone erosion is a pathological condition characterized by breaks in the cortical bone surface and loss of the adjacent trabecular bone. Several pathological processes can lead to bone erosion, including malignant tumors, abnormal metabolic processes such as hyperparathyroidism, and chronic inflammatory diseases such as rheumatoid arthritis. In clinical settings, bone erosion is routinely detected using X-ray based imaging technologies such as computed tomography (CT). Although preclinical CT offers high resolution 3D imaging for bone, accessibility to this modality may be challenging. Learn how optical and high-resolution X-ray imaging capability on the IVIS Lumina X5 system and Living Image® software was used for obtaining high quality images for quantitative analysis in a mouse bone erosion model, with the ease and speed of 2D imaging.

  • Application Note

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • Poster

    Molecular imaging of tumor energy metabolism as an early indicator of anti-cancer drug efficacy in small animal models

    Targeted cancer therapy aims to block key signaling pathways that are critical for tumor cell growth and survival. The blockage eventually results in cell death via apoptosis and tumor growth suppression. Encouraged by the success in clinical development, many academic and pharmaceutical researcher are in active pursuit of the improvement of next generation targeted anti-cancer drugs. As a result, many new chemical and biological entities are emerging from initial screening of in vitro, in vitro and/or in silico selection processes. From the perspective of drug development, it poses a great challenge on the next stage of in vivo validation and demands a robust, accurate, and efficient method for assessment of these candidates in living animal models.

  • Application Note

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • Application Note

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • Technical Note

    Tips for removing background fluorescence in your in vivo imaging models

    In vivo optical imaging can provide information at the cellular biomarker level regarding disease states and therapeutic response. Bioluminescence imaging presents few challenges with respect to imaging and data acquisition. However, fluorescence imaging requires strategies to compensate for background fluorescence. Without proper background subtraction, results may underestimate biological changes or the magnitude of therapeutic efficacy of a drug. There are several contributors to background fluorescence which can vary depending on disease model and probe used all of which need to be considered when developing a mouse model for fluorescence imaging. Learn about key considerations for defining and applying background correction to improve fluorescence quantification and interpretation using the IVIS® platform in this technical note.