E. coli - Xen14 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from the parental strain E. coli WS2572, a clinical isolate from Weihenstephan Culture Collection. E. coli-Xen14 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
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For laboratory use only. This product is intended for animal research only and not for use in humans.
Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. PerkinElmer's bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers, e.g., lung, sepsis, meningitis, GI, and biofilm infections.
Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:
Advantages of using bioluminescent light-producing microorganisms for drug discovery in vivo:
|Gram Positive Gram Negative||Gram negative|
|Luciferase Classification||Bacterial luciferase|
|Optical Imaging Classification||Bioluminescence Imaging|
|Product Brand Name||XenoLight|
|Therapeutic Area||Bacterial infection|
|Unit Size||1 agar plate|
Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.
The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.