For laboratory use only. This product is intended for animal research only and not for use in humans.
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VivoTag-S® 680 Fluorochrome is an amine-reactive near infrared (NIR) fluorochrome for coupling via an NHS ester linkage to peptides, small molecules, proteins, antibodies or macromolecules. Availbable in 5 mg size.
|Fluorescent Agent Type||Labeling|
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||VivoTag|
|Quantity in a Package Amount||1.0 Units|
|Shipping Condition||Blue Ice|
|Unit Size||5 mg|
|Wave Length||680 nm|
N-Hydroxysuccinimide (NHS)-ester labeling reagents, such as VivoTag®-S reagents, are commonly used for labeling proteins. The NHS ester moiety reacts with amino groups at pH 7-9 to form stable amide bonds. Lysines within proteins, including antibodies, are available as targets for this chemical conjugation.,Protein labeling efficiency may vary depending upon the type of protein labeled, so different conjugation ratios may need to be attempted to attain success. For Near Infrared (NIR) fluorophore conjugation, ratios of fluorophore to protein of 4:1 have been seen to generate effective imaging agents. Not all antibodies or proteins (independent of target specificity) make good imaging agents, due to long half-lives and/or excessive accumulation in non-target sites.
We have developed a novel FAST (“Fluorescent Activatable Sensor Technology”) in vivo imaging agent based on an angiotensinogen substrate sequences that is selectively cleaved and activated by rodent renin. ReninSense680 FAST, a PKM-modified agent suitable for invivo administration, distributes to the kidney, is activated in a model of renin upregulation, and provides a tool for in vivo imaging and quantification of the changes in renin activity inkidneys and plasma.
VivoTag-S® 680 is an amine reactive near-infrared (NIR) fluorochrome (NHS ester) for labeling biomolecules for in vivo imaging applications.