For laboratory use only. This product is intended for animal research only and not for use in humans.
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VivoTag® 645-MAL is a thiol (-SH, sulfhydryl) reactive maleimide-containing red fluorochrome for molecular labeling applications. VivoTag 645-MAL Fluorochrome is optimized and integrated for both in vivo _and _in vitro imaging applications. VivoTag 645-MAL Fluorochrome's superior brightness makes it particularly well suited for the labeling of thiol and cysteine containing molecules for a wide range of imaging applications. The 645 nm fluorescence wavelength is ideal for biological imaging applications on in vitro and in vivo fluorescence systems.
|Fluorescent Agent Type||Labeling|
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||VivoTag|
|Shipping Condition||Blue Ice|
|Unit Size||1 mg|
|Wave Length||645 nm|
VivoTag® 645 is a red fluorescent labeling agent containing an N-hydroxysuccinimide (NHS)-ester. Labeling reagents, such as VivoTag 645 reagent, are commonly used for labeling proteins. The NHS ester moiety on VivoTag 645 reacts with amino groups to form amide bonds. Lysines within proteins, including antibodies, are available as targets for this chemical conjugation.,Protein labeling efficiency may vary depending upon the type of protein labeled, so different conjugation ratios may need to be attempted to attain success. For red fluorophore conjugation, ratios of fluorophore to protein of 4:1 have been seen to generate effective imaging agents. Not all antibodies or proteins (independent of target specificity) make good imaging agents, due to long half-lives and/or excessive accumulation in non-target sites.
Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.
The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.