Now with Alpha Technology, the VICTOR® Nivo™ system packs all popular detection modes into the industry’s smallest multimode reader footprint. The perfect microplate reader for everyday biochemical and cell-based assays, it measures at any wavelength, with top and bottom reading of all standard technologies (top only reading for Alpha). Its software interface is easy to learn and use, and lets you control the instrument from almost any device – perfect for multiuser environments. Combine with our assays and reagents to get you started right away.
For research use only. Not for use in diagnostic procedures.
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For research use only. Not for use in diagnostic procedures.
The VICTOR Nivo system is a high-performance filter-based multimode microplate reader equipped with all major detection technologies:
It’s a compact, light-weight multimode plate reader designed for life science research laboratories performing routine low-throughput assays, or assay development work, with diverse application requirements. When combined with the stacker, throughput for the VICTOR Nivo is increased and productivity is enhanced by enabling users to set up walk away automation so they can focus on their research and not on managing plates.
The VICTOR NIVO system’s software has a modern, workflow-oriented user interface which is easy to learn and use and includes pre-written application protocols to get users productive quickly. In addition, MyAssays Desktop Standard software is provided for data analysis. With our Enhanced Security software option, it contains technological tools to help guide you through the complexity of compliance for 21 CFR Part 11.
The browser-based control software is independent of operating system, so it can be controlled via a variety of touchscreen devices, for example Windows or Mac OS PCs or tablets.
The VICTOR Nivo microplate reader can be operated via WiFi or a network connection, enabling experiments to be set-up, run and monitored remotely, such as from outside a biosafety cabinet or from a neighbouring lab.
Dynamic Rainbow Filter Exchanger
Every VICTOR Nivo comes rainbow-ready with our dynamic double-layered filter wheel system that can store up to 32 filters. When fully loaded, the system is equipped to address virtually any application, with better sensitivity than a monochromator.
For absorbance measurements using the VICTOR Nivo multimode plate reader, there is a choice of either a filter- or a spectrometer-based system. With the spectrometer-based plate reader, full spectrum absorbance measurements are ultra-fast – 230 to 1000 nm at selectable resolutions (2.0 nm, 5.0 nm, 10 nm) in less than 1 second per well.
Up to eight discrete wavelengths can be detected at once in a single measurement with no wavelength switching, and the spectrometer-based VICTOR Nivo system also allows the detection of a wide range of dyes or measurement of samples with unknown absorbance spectra.
Features & Benefits
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|Detection Method||Absorbance, Time-Resolved Fluorescence (TRF), Luminescence, Alpha, Fluorescence Intensity, Fluorescence Polarization|
|Product Brand Name||VICTOR Nivo|
|Modalities||VICTOR Nivo F||VICTOR Nivo S||VICTOR Nivo Alpha F||VICTOR Nivo Alpha S||Standard Features||Optional Extras|
(Filter-based (F) or Spectrometer (S))
Monitoring of bacterial growth is a fundamental technique in microbiology. The most widely used method for enumerating bacteria is plate-based counting, which requires serial dilutions of the bacterial stock culture and manual counting of colonies after plating. The procedure is very time consuming and cost intensive, as plates must be prepared, inoculated and counted manually. Running the assay in a microplate format and using a plate reader to measure bacterial growth greatly reduces consumables and waste. Automating sample preparation with an automated liquid handler helps to further reduce hands-on time and improve precision.
In this application note, we present the adaptation of a microplate-based assay on the VICTOR® Nivo™ multimode plate reader for automated detection of bacterial growth assay, using the readout for optical density (OD)/turbidity. The integrated temperature control and shaking function of VICTOR Nivo allows the realization of controlled assay conditions, helping to prevent common issues such as condensation under the plate lid, and allowing continuous detection of changes in turbidity over time. Download our application note to learn more.
There are many different methods of quantification available on the market for DNA samples and each can vary in precision, accuracy and throughput. Typically, DNA in next generation sequencing (NGS) workflows is measured using tube-based fluorescent assays such as Qubit® or qPCR. However, since samples have to be measured one at a time, this can create bottlenecks in a high-throughput lab. Using an automated liquid handler and plate reader instead of manually pipetting tube-based measurements can significantly decrease measurement time and increase throughput.
Download our application note to learn how we obtain consistent, reproducible and high-throughput results using the VICTOR® Nivo™ multimode plate reader in conjunction with the Zephyr G3 NGS workstation to quantify DNA with reagents from Quant-iT® assay kits.
In this application note, the VICTOR® Nivo™ multimode plate reader is used in combination with MyAssays® Desktop Software to perform kinetic assays and analyze data in a straightforward and efficient manner.
ADAMTS13 is a biomarker of thrombotic thrombocytopenic purpura (TTP), a rare disease that can be controlled by plasma exchange which is supposed to supply ADAMTS13 to patients and/or to remove neutralizing autoantibodies against ADAMTS13.
VICTOR Nivo was used to measure the activity of the enzyme ADAMTS13 in plasma samples, using the commercial substrate “FRETS-VWF73”. As variant of the original protocol, PerkinElmer half-area plates were used to save reagent and sample (assay volumes reduced by half as compared to the original protocol).
Read this application note to learn more about running sensitive biochemical, kinetic assays efficiently with VICTOR Nivo and MyAssays® Desktop Software.
Knowing the protein concentration is commonly required in studies of protein biochemistry and molecular biology. A direct method of measuring protein concentration is to determine the absorbance spectrum at 280 nm. With this UV based approach, it enables scientists to rapidly determine the concentration of protein with a procedure that is simple and nondestructive, does not need special reagents or standard curves, and consumes very little sample.
In this study, learn why the VICTOR® Nivo™ multimode plate reader is an ideal instrument for UV/Vis analysis of proteins with a µDrop™ Plate. This combination provides robust and fast read-out of a single sample or up to 16 reads at once.
Gene therapy is a very powerful tool that is currently being explored to combat disorders with underlying genetic causes. Within the field of neurological diseases, there is great interest looking at rare diseases of monogenic origin with the hope of developing disease-modifying gene therapies, as opposed to treatments for symptom management. Therefore, using relatively tunable systems like recombinant AAVs (rAAVs), scientists are also exploring in vivo gene delivery in parallel to ex vivo.
Like the brain, neuroscience has a multitude of layers. Our broad solutions, innovative technologies, and proven expertise help researchers like you understand neurological diseases so that patients can benefit from better treatments and therapies.
This Brochure describes the VICTOR Nivo Multimode Plate Reader.
Selecting the right plate reader for your lab can be challenging. There are multiple factors to consider including: detection type, additional features, support, and price. With numerous options for each variable, it can be confusing to navigate the selection process. Focusing on striking a balance between functionality, optimization, and growth potential requires keen insight and continued vendor support throughout the life cycle of the plate reader.
This detailed guide will help you choose the right plate reader for your needs by examining the marketplace and pointing out considerations to keep in mind when making your decision.
Reaching compliance according to the laws and regulations of each country can be a tedious, complicated process, and being GxP compliant (FDA 21 CFR Part 11, EU Annex 11, etc.) is necessary in order to deliver therapeutic treatments to market for pharmaceutical and biotechnology companies, including clinical research organizations.
Simplify compliance for your VICTOR® Nivo™, EnSight®, or EnVision® multimode plate reader with the help of our Enhanced Security software. In addition, our wide range of assays can help you achieve your research goals, and our qualification services will make sure your multimode plate reader and software are operating at the recommended technical specifications.
To guide you through the complexity of the compliance process, we can help with our proven solutions, customer training, and technical support so you can focus on your science and research.
All life science related fields from basic research in academia to commercial diagnostics laboratories rely on quick and simple, yet highly accurate quantification of nucleic acids. Commonly, photometers are employed to determine quality, purity, and concentration by measuring the absorption of the probe using light in the ultra-violet (UV) range with wavelengths of 230, 260, 280, and 320 nm. While the absorption of 230 nm light indicates contamination with organic compounds, salt, sugar, or phenol, 320 nm serves as background correction. Nucleic acids and proteins show absorption maxima at 260 and 280 nm, respectively.
Alpha technology is a homogenous bead-based proximity assay with a solution for just about every research application. To bring this technology to research environments with lower budget capabilities, the VICTOR® Nivo™ multimode plate reader is now available with all optical components for high Alpha performance technology.
In this technical note, we qualified the Alpha-enabled VICTOR Nivo on the basis of critical assay parameters by testing two AlphaLISA® assays, human insulin and p24 (human HIV). The human insulin AlphaLISA kit is widely used for the quantitative determination of human insulin in serum, buffered solution or cell culture. Insulin is a key player in the control of both carbohydrate and lipid metabolism and has been implicated in various diseases including diabetes, heart disease and obesity. Learn more.
Using ELISA technology for immunoassays on a plate reader is laborious and time-consuming because it requires numerous wash steps. In the field of drug discovery, technologies that give robust, sensitive, automatable, and reproducible immunoassays at a lower cost are highly desirable.
Alpha Technology simplifies an assay workflow and accelerates time-to-results because no wash steps are needed. Learn more on the advantage of AlphaLISA® with its quicker time-to-results, simplified assay workflow, and improved assay robustness and reproducibility on the VICTOR® Nivo™ multimode plate reader, now with Alpha detection.
Cell-based assays are routinely employed in R&D to reveal compound induced effects in vitro. In this technical note, we describe the usage of the VICTOR® Nivo™ multimode plate reader for alpha-tubulin acetyl-K40 detection in a cellular assay based on HTRF® technology. Tubulin acetylation is widely studied due to its dysregulation in human neurological disorders. To demonstrate the HTRF assay principle on the VICTOR Nivo, we used mouse fibroblasts (NIH-3T3 cells).
The HTRF certified VICTOR Nivo optimally supports the application of HTRF kits. Learn how easy it is to use the cell-based alpha-tubulin acetyl-K40 HTRF assay kit on the instrument.
Ensuring that laboratory processes are compliant with the regulations of the U.S. Food and Drug Administration (FDA), such as 21 CFR Part 11, and other references, e.g. Annex 11 published by the European Commission, can be time-consuming and laborious, requiring meticulous documentation of procedures and record-keeping.
To help ensure that procedures which involve the VICTOR® Nivo™ multimode plate reader are compliant, an add-on to the instrument's software is available. Named the Enhanced Security option, this software provides a variety of tools to help you reach compliance for 21 CFR Part 11. With specific reference to the relevant paragraphs of 21 CFR Part 11, this document describes how the tools within the VICTOR Nivo Enhanced Security software facilitate compliance with this regulation.