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Vasopressin, [125I]Tyr2, Arg8-, 50µCi (1.85MBq)

Vasopressin, labeled with 125I on tyrosine residue 2. Vasopressin binds and activates vasopressin receptors, a group of GPCRs that are potential drug targets for hyponatremia, congestive heart failure, and cirrhosis.

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NEX128010UC
10 µCi
912.00 USD
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NEX128050UC
50 µCi
2148.00 USD
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX128:

  1. Thiesson, H.C., Skøtt, O., Jespersen B., Schaffalitzky de Muckadell, O.B. (2003), Nitric Oxide Synthase Inhibition Does Not Improve Renal Function in Cirrhotic Patients With Ascites, American Journal of Gastroenterology 98, 180–186.
  2. Lishajko F, Appelgren B, Eriksson S. (1981) Cerebral sodium/angiotensin interaction studied by RIA-determination of urinary arginine vasopressin in the hydrated goat. Acta Physiol Scand. 111(3):311-8.

Specifications

Detection Method Radiometric
Fresh Lot Days Second Monday of each month
Label Position Nominally Labeled
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Vasopressin
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Metabolic Disorders
Unit Size 50 µCi
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Using the NENSure Packaging System from PerkinElmer

Since 1985, the unique NENSure system has set the standard for radiochemical packaging. Based on proven performance over millions of shipments, the system provides: Ease of use, Safe storage of unused product and Reduced radiation exposure. Many NEN brand research products, including 32P-, 33P-, 35S-, 3H-, 14C- and 125I-labeled compounds, are packaged in the NENSure System, as are most radionuclides.

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