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U-69,593, [Phenyl-3,4-3H]-, 25µCi (925kBq)

U-69,593, tritiated at the phenyl-3,4 position. U-69,593 is a selective κ1-opioid receptor agonist.

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NET952025UC
25 µCi
691.00 USD
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NET952250UC
250 µCi
2253.00 USD
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Detail Information

U-69,593 acts as an agonist at kappa 1 opioid receptors (KORs). These receptors are a class of GPCRs involved in pain, consciousness, stress, and mood.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET952:

  1. Meng F, Xie GX, Thompson RC, Mansour A, Goldstein A, Watson SJ, and Akil H (1993) Cloning and pharmacological characterization of a rat kappa opioid receptor. Proc Natl Acad Sci USA 90:9954–9958.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 356.5
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Opioid
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Pain, Inflammation
Unit Size 25 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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