Automated headspace sampler with built-in trap and standard PerkinElmer 9mL or 22mL sample vials.
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Up to 40 vials can be loaded into the removable vial magazine for automated analysis. Overlapping thermostatting of up to 12 vials in Constant Mode for maximum productivity. A patented optimization algorithm adjusts the virtual oven size for maximum throughput. An optional frequency-scanning shaker is available to reduce equilibration time. No optimization of the shaking process is required.
|Maximum Temperature||32 °C|
|Minimum Temperature||15 °C|
|Product Brand Name||TurboMatrix|
Butylated hydroxytoluene (BHT) is a common food additive used to protect foods from spoilage. Concern exists that long-term human consumption of BHT may have potential health risks. Analysis of BHT is needed for both food quality and safety reasons.
Although considered pharmacologically inert, pharmaceutical excipients have been shown to interact with active drug substances to affect the safety and efficacy of drug products.1 Therefore, there is an increasing awareness of the necessity to understanding interactions between excipients and the active pharmaceutical ingredient (API) in finished dosage forms. One of the areas of major concern is the potential chemical interaction between impurities in the excipient with the drug molecules, leading to formation of reaction products. Even trace amounts of reactive impurities can cause significant drug stability problems as the quantity of excipients in a formulation often far exceeds that of an API on a weight and molar basis. Trace amounts of reaction products can then easily exceed 0.2% qualification thresholds for a degradation in many drug products. Formaldehyde present in excipients has been implicated in the degradation of several drug products where it can form adducts with primary and/or secondary amine groups.2 It has also been reported that formaldehyde can induce cross-linking in gelatin capsules causing an adverse effect on in-vitro dissolution rates of drugs. Because of the extremely high reactivity of aldehydes, a timely evaluation of their presence in excipients during formulation design is essential to avoid unexpected drug stability problems in later stages of product development.
Chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs) are fully or partially halogenated paraffin hydrocarbons. CFCs, in the form of polyether polyol mixtures, have been widely used as blowing agents in the manufacture of rigid polyurethane foams (PU) used as insulation products. Owing to the contribution to ozone depletion, the manufacturing and use of CFCs and HCFCs have been phased out under the Montreal Protocol (1987), however, recent studies have found that atmospheric levels of CFCs are significantly higher than expected, suggesting that production and use of CFCs are still on-going. In this study, trichlorofluoromethane (CFC-11), chlorodifuoromethane (HCFC-22) and dichlorofluoroethane (HCFC-141b) in a polyether polyol matrix are investigated using a PerkinElmer Clarus® GC/MS with a TurboMatrix™ HS-40. Instrument method parameters utilized in the study are presented herein, with detailed results demonstrating superior precision, linearity, sensitivity and recovery.
Volatile organic compounds (VOCs) are a series of compounds with high vapor pressure and boiling points from 50 to 250 degrees centigrade. These characteristics lead to the tendency for large numbers of molecules to evaporate, or volatilize, from their solid state into the air. VOCs are present in the environment from a number of sources, both anthropogenic and naturally occurring. In soil, VOCs are mainly derived from discharged industrial and domestic sewage, oil spills, and chemical solvent leakages. Monitoring of VOC contamination in soils by both qualitative and quantitative analyses is important to ensure that the potential negative health impacts of VOC exposure are mitigated. In this study, thirty seven VOCs are investigated in a soil matrix, using a PerkinElmer Clarus® GC/FID and TurboMatrix™ HS-40. Detailed instrument method parameters are presented with precision, linearity and reporting limit results.
Epichlorohydrin, a raw material found in resins, can occur in drinking water at concentration which are hazardous to human health. The use of ephichlorohydrin is increasingly regulated. This article presents an analytical technique to determine the concentration of epichlorohydrin in the drinking water, in response to the requirements of the European Normative 98/83/EC, which recommends limiting the concentration to a maximum of 0.1 ug/L.
This application note demonstrates the use of a new sample-introduction technology incorporated in TurboMatrix HS-110 Trap for U.S. EPA Method 8260B for analysis, identification and quantification of volatile organic compounds (VOCs) that have boiling points below 200 °C.
Although considered pharmacologically inert, pharmaceutical excipients have been shown to interact with active drug substances to affect the safety and efficacy of drug products. One of the areas of major concern is the potential chemical interaction between impurities in the excipient and the drug molecules, leading to the formation of reaction products. Formaldehyde present in excipients has been implicated in the degradation of several drug products where it can form adducts with primary and/or secondary amine groups. It has also been reported that formaldehyde can induce cross-linking in gelatin capsules causing an adverse effect on in-vitro dissolution rates of drugs.
This application note presents a simple and effective method for the determination of formaldehyde in pharmaceutical excipients using SHS-GC/MS. The method is fast, reliable and can be used for the quantification of low-molecular-weight aldehydes in most excipients commonly used in pharmaceutical products.
ASTM International publishes a number of different methods for the determination of volatile compounds in water-based coatings. Method D3960 is a gravimetric technique where a sample of known weight is baked under specific conditions; the % weight of volatile organic compounds (VOCs) is calculated from a series of measured masses. The method that was presented here will reliably analyze difficult compounds in a difficult matrix with great precision, linearity, and without carryover.
The development of methodology to measure VOCs at low levels using GC-MS coupled with Headspace Trap sample introduction is described here. The methodology is based on U.S. EPA Method 8260B.
Increasing demands for efficiency, productivity, data quality, and profitability pose ongoing challenges for lubricant testing labs, like yours. Whether you need to achieve quick turnaround times, minimize downtime, or maximize lab efficiencies, you can rely on PerkinElmer for a comprehensive set of simple-to-use and proven testing solutions to help you achieve accurate results in record time. Learn more about our solutions.
Headspace Gas Chromatography—for applications involving the solvent-free extraction of volatile compounds, it’s an unsurpassed technique, eliminating the time-consuming steps and risk of human error associated with other GC sample-preparation methods.
This field application report describes the use of a TurboMatrix™ HS-110 Trap and Clarus® 500 GC/MS optimized for low-level determination of fuel oxygenates by U.S. Environmental Protection Agency Method 8260B using the new headspace-trap technology.
Consumables reference guide for the TurboMatrix Headspace. TurboMatrix Headspace and high-sensitivity Headspace Trap samplers provide unparalleled precision and ease of use for numerous GC or GC/MS volatile-analysis applications. The system can manage up to 12 samples simultaneously, ensuring that the next sample is ready for analysis upon completion of the previous run, achieving significant time savings.
The Polymer Market consists of a huge diversity of manufacturers of industrial products running many different processes yet still facing similar challenges. There is more and more pressure to achieve high product quality and reduce costs in order to stay one step ahead of the competition.