PerkinElmer
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Transferrin-Vivo 750

Transferrin is an important serum protein that mediates iron transport into cells via the transferrin receptor, a function that is essential for cell growth and metabolism. PerkinElmer’s Transferrin-Vivo 750 fluorescent probe is a NIR-labeled in vivo imaging agent that detects transferrin receptor levels associated with an altered metabolic need for iron in cancer and inflammatory cells. Transferrin-Vivo 750 fluorescent agent can also detect normal transferrin receptor levels in the liver as well as decreased expression due to altered iron metabolism associated with drug-induced liver injury.

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Fluorescent Agent Type Targeted
Product Brand Name Transferrin-Vivo
Quantity in a Package Amount 1.0 Units
Shipping Condition Blue Ice
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Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts

Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more important to integrate safety/toxicology assessments earlier in the drug development process. There are a variety of traditional serum markers, tailored mechanistically to specific tissues, however there are no current non-invasive assessment tools that are capable of looking broadly at in situ biological changes in target and non-target tissue induced by chemical insult.

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