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Thyrotropin Releasing Hormone (3-methyl-histidine2), [L-histidyl-4-3H(N), L-propyl-3,4-3H(N)]-, 50µCi (1.85MBq)

Thyrotropin-releasing hormone (TRH), tritiated on the histidyl and propyl groups. TRH binds and activates thyrotropin-releasing hormone receptors (TRH-Rs).

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NET705050UC
50 µCi
1642.00 USD
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NET705250UC
250 µCi
6000.00 USD
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Detail Information

TRH is the endogenous ligand for thyrotropin-releasing hormone receptors (TRH-Rs), and is used to treat spinocerebellar degeneration and disturbance of conciousness. TRH-R is a family of GPCRs involved in the secretion of thryoid-stimulating hormone and prolactin.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET705:

  1. Kelly, J.A. et al. (2015) First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models, Neuropharmacology, 89: 193-203.
  2. Drmota, T. and Milligan, G. (2000) Kinetic analysis of the internalization and recycling of [3H]TRH and C-terminal truncations of the long isoform of the rat thyrotropin-releasing hormone receptor-1, Biochemical Journal, 346 (3): 711-718.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Nominally Labeled
Molecular Weight 376.4
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Thyrotropin Releasing Hormone
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 50 µCi