Sphingosine, [3-³H]-, D-erythro>97%, 50µCi (1.85MBq)

Sphingosine is component of sphingolipids, a class of cell membrane lipis and phospholipids. Sphingosine can be phosphorylated by sphingosine kinase type 1 and sphingosine kinase type 2, producing sphigosine-1-phosphate. References:

1. Ikeda, H. et al. Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. Gastroenterology 124, 459–469 (2003).
2. Goldkorn, T. et al. Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action. J. Biol. Chem. 266, 16092–16097 (1991).
3. Wang, E., Norred, W. P., Bacon, C. W., Riley, R. T. & Merrill, A. H. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 266, 14486–14490 (1991).
4. Olivera, A. et al. Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation. J. Biol. Chem. 269, 17924–17930 (1994).