Spectrum 3 MIR-NIR Extended Range Spectrometer

Infrared Spectroscopy has become a ubiquitous tool in the analysis of pharmaceutical raw materials, with both Mid- and Near-infrared spectroscopy functioning as commonplace techniques for the investigation of both excipients and active pharmaceutical ingredients (APIs). Near-infrared spectroscopy is arguably the most common spectroscopic technique for the interrogation of incoming raw materials. Mid-infrared spectroscopy generally contains the most information regarding the chemical structure of an analyte, making it particularly useful for identification and analysis of active materials in pharmaceutical samples. This application note describes how the PerkinElmer Spectrum 3 FT-IR spectrometer together with the 21 CFR part 11 compliant Spectrum 10 software provides a high-performance solution for mid and near infrared analysis of materials used in the pharmaceutical industry.

A typical FT-IR spectrometer will scan down to the long wavelength limit of approximately 400 cm-1 limited by the optical components such as the beamsplitter and detector which contain potassium bromide (KBr). However, there are a growing number of applications where the materials of interest exhibit spectral absorptions much further into the far-infrared region requiring instruments that can scan down below 100 cm-1. This application note describes how the Spectrum 3 tri-range version allows for multiple optical components to be installed on a single instrument allowing for coverage of a wide spectral range from 10,000 - 30 cm-1.

Spectroscopic techniques, especially infrared (IR) spectroscopy, can give specific chemical information, identifying intermediates and products during extremely fast reaction based on the spectral information collected. Modern FT-IR (fourier transform infrared) spectrometers have fast scan capabilities allowing for fast chemical reactions to be monitored in real time. The coupling of an FT-IR spectrometer with a stopped flow system can generate significant spectral and chemical information whilst retaining the integrity of the fast chemical reaction. This application note describes how the PerkinElmer Spectrum 3 equipped with the stopped-flow system provides valuable information on rapid kinetic experiments.

Resins are used universally in the manufacture of a vast range of goods including electronics, disposable medical devices and even aerospace components. The polymerization reaction responsible for curing resins varies depending on the monomers used. One of the most commonly used types of resin valued for their rapid curing and strength of bond are cyanoacrylates, otherwise known as ‘superglues’. Due to the wide range of resin formulations with different uses and physical properties, it’s important to monitor and understand the mechanisms responsible for curing as well as their rates in order to optimize their efficient usage. This application note describes how the PerkinElmer Spectrum 3 FT-IR with a Universal Attenuated Total Reflectance (UATR) accessory may be used to measure the change in spectral information as the resin cures.

Spectroscopic analysis of glass used in both construction and the automotive industry is required to determine several very important parameters such as emissivity of glass to investigate their energy-saving capability. These measurements are carried out in the Mid- and Far-infrared regions. Infrared spectroscopy has also become a standard method in the analysis of pharmaceutical materials with the advantage of being fast and non-destructive. The near and mid-infrared regions are the most commonly used as they can provide detailed information about chemical structure (mid-infrared) and physicochemical properties (near-infrared). However, there are also some research applications of far-infrared spectroscopy such as the determination of solid-state structural properties and polymorphism studies.

This application note demonstrates the ability of the PerkinElmer Spectrum 3 to measure in multiple regions of the infrared spectrum to provide an all-in-one infrared solution for a wide variety of markets.

Innovation is the lifeblood of industrial polymer development – the push to improve materials or develop new ones infuses new life into the industry from R&D through to QA/QC. Manufacturers are continually challenged to ensure effective quality control and streamline processes while meeting stringent standards. Increasingly they must design for recycling and/or reuse in an ever more waste-adverse economy, keep a watchful eye on costs and stay ahead of the competition.

In response, we've gained years of experience developing a range of analytical capabilities to address a wide range of polymer analysis needs.

Download the interactive brochure to learn more about the most common challenges and our solutions in the market.

Food testing labs like yours are constantly challenged with accurately analyzing samples quickly and efficiently – all while striving to reduce costs due to market forces. In this brochure you can find a range of solutions across multiple technologies, products, and services that meets or exceeds the testing needs of meat and seafood processors. Our solutions offer more efficiency and increased accuracy and sensitivity for better yields in real time with minimal training.

The PerkinElmer Spectrum 3 FT-IR spectrometer provides the sampling flexibility and analytical performance in mid, near, and far infrared ranges through a single instrument to advance research and new product development in academia, chemicals, polymers, and pharmaceuticals. Read the interactive brochure to learn more about the patented technology, applications, and service that PerkinElmer offers to make Spectrum 3 a complete solution to advance your science.