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NULL OR EMPTY CART
|Inner Diameter||4.6 mm|
|Particle Size||2.6 µm|
|Product Brand Name||Quasar|
Fluconazole is an azole anti-fungal medication used primarily in the treatment of a wide range of fungal infections. Examples include thrush, urinary tract infections and the prevention of fungal infections in immunocompromised patients undergoing chemotherapy. The mechanism of action can be described as fungistatic, the growth and replication of fungi is inhibited by fluconazole rather than directly attacked. This process is achieved by inhibiting enzymes which are important in the production of fungal membranes, allowing the immune system ample opportunity to target and degrade the pathogen. Fluconazole has generic status and is thus globally produced and prescribed. It is on the World Health Organization’s (WHO) list of essential medicines, which serves as a model of the safest and most effective medications needed by a health system. This application brief describes the use of a Quasar C18, on both porous silica and SPP silica phases, for the analysis of fluconazole in accordance with the official USP monograph.
Pharmaceuticals are continuously entering our waterways via human excretion of incompletely absorbed medication and improper disposal of unused drugs via drains and toilets. A report found that the six most consistent highest reported concentrations in finished drinking water for active pharmaceutical ingredients (APIs) were from ibuprofen, triclosan, carbamazepine, phenazone, clofibric acid, and acetaminophen.
Ibuprofen (Figure 1) is a widely used analgesic and antipyretic for adults and children and since it’s one of the most reported pharmaceutical in finished drinking waste, it is important to determine the amount removed by different water treatment processes. HPLC is an essential technique to determine the quantity of ibuprofen in water and help optimise a process for its removal. This application brief describes the use of a Quasar superficially porous particles (SPP) C18 column for the analysis of ibuprofen in water.
The most commonly used LC reversed-phase alkyl bonded stationary phase is octadecyl carbon chain (C18)-bonded silica, which is denoted as USP classification L1. C18 columns have a broad applicability from pharmaceuticals to food and environmental analyses. However, not all C18 columns are alike. Simply swapping a C18 column from one manufacturer to another can result in differences in retention time, resolution and even selectivity. Differences can arise due to variations in hydrophobicity, silanol activity, packing quality, particle size distribution, and silica purity, to name a few.
This technical note provides details of a comparative study between twenty-four silica-based C18 phases, from a number of manufacturers covering the following areas: