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|Inner Diameter||2.1 mm|
|Particle Size||3.0 µm|
|Product Brand Name||Quasar|
Fluoxetine hydrochloride is an antidepressant belonging to a class of drugs known as selective serotonin reuptake inhibitors. It was notably marketed as Prozac. Fluoxetine is also effective at treating obsessive compulsive disorder and bulimia. It blocks the serotonin reuptake transporter in the presynaptic terminal which results in increased levels of serotonin in certain areas of the brain. Fluoxetine is favorable in comparison with older antidepressants as it is a selective inhibitor for serotonin, has weak affinity for noradrenaline receptors and no affinity for dopamine receptors, giving it a far more desirable adverse effect profile. This application brief describes the use of a Quasar™ C8 column for the analysis of fluoxetine hydrochloride in accordance with the official Fluoxetine Hydrochloride USP monograph.
Lopinavir and ritonavir are commonly prescribed as a fixed-dose combination drug therapy for the treatment of Human Immunodeficiency Viruses (HIV) and belong to a class of antiviral drugs known as protease inhibitors. Lopinavir by itself has insufficient bioavailability to be an effective therapy. However, ritonavir inhibits cytochrome P450 enzymes in the liver known to break down lopinavir, increasing its concentration in the blood to its desired therapeutic window. Lopinavir and ritonavir treatment as a single medication is listed by the World Health Organization’s (WHO) list of essential medicines, which serves as a model of the safest and most effective medicines required by a health system. Early studies have shown promising results as a treatment against SARS-CoV-2 and further research is currently being conducted into its efficacy. This application brief describes the use of a Quasar C8 column for the analysis of lopinavir and ritonavir.
Olopatadine hydrochloride is an antihistamine used to treat itching and redness in the eyes due to allergies. It is commonly available over the counter in several forms such as eye drops and as a nasal spray. Olopatadine was used in 1996 and 2002 to treat allergic conjunctivitis. In 2017, it was the 290th most prescribed medication in the United States, with more than one million prescriptions.
This application brief describes the use of a PerkinElmer Quasar™ C8 (150 x 4.6 mm, 5 µm) column in accordance with the official olopatadine hydrochloride USP monograph.
Omeprazole belongs to a class of drugs known as Proton Pump Inhibitors (PPI’s). It is used in the treatment of conditions relating to overactive stomach acid such as gastroesophageal reflux disease, peptic ulcers and Zollinger-Ellison syndrome. The World Health Organization regards omeprazole among its ‘List of Essential Medicines’ which outlines the most effective and safest medicines required by a countries healthcare system to meet its needs. Omeprazole is a very commercially important drug, being ranked as the 7th most prescribed drug in the USA in 2017 with over 58 million prescriptions. This application brief describes the use of a Quasar C8 column for the analysis of omeprazole in accordance with the United States Pharmacopoeia (USP) monograph.
Paracetamol, also known as acetaminophen, is an analgesic/antipyretic drug, that reduces fever and pain and is ubiquitous in treating these symptoms. Providing relief for these common symptoms combined with the fact that paracetamol is very well tolerated (in comparison with other analgesics such as aspirin) go towards explaining why it is so widely used. Paracetamol has generic status with many manufacturers making it a commercially important compound. Despite being so widely used the mechanism of action of paracetamol is not fully known. It has been shown to interact with same enzymes as non-steroidal anti-inflammatory drugs, but exclusively in the central nervous system as oppose to the periphery. This application brief describes the use of a Quasar C8 for the analysis of paracetamol adapted from the official USP monograph.
Tadalafil is a drug used in the treatment of pulmonary hypertension (high blood pressure in blood vessels that supply the lungs) and is also used to treat erectile disfunction (ED) and symptoms of an enlarged prostate. It is on the World Health Organization’s (WHO) list of essential medicines, which serves as a model of the safest and most effective medications needed by a health system. This application brief describes the use of a PerkinElmer Quasar™ C8 column to analyze tadalafil in accordance with the official USP monograph.
Venlafaxine is an antidepressant which belongs to a group of medicines called serotonin and norepinephrine reuptake inhibitors (SNRIs). This group of medicines is used to treat depression and other conditions such as anxiety. It is thought that people who are depressed and/or anxious have lower levels of serotonin and noradrenaline in the brain and venlafaxine should improve your mood and energy level and may help restore your interest in daily living.
Venlafaxine is on the World Health Organization’s (WHO) list of essential medicines, which serves as a model of the safest and most effective medications needed by a health system. This application brief describes the use of a PerkinElmer Quasar™ C8 (250 x 4.6 mm, 5 µm) column in accordance with the official venlafaxine hydrochloride USP monograph.
Whether you need high-performance liquid chromatography (HPLC) or ultra-high performance liquid chromatography (UHPLC), with our versatile LC 300 solutions you can count on the right technology for the work you do. The LC 300 systems provide robust, trouble-free operation and are perfect for routine analysis and more demanding applications, giving you the highest sensitivity and resolution, as well as faster results.