Quasar™ C18 LC columns, based on ultra high purity silica and manufactured to tight specification, provides high efficiency separations and excellent peak shape for a wide range of compounds. Our methodology to yield high surface coverage enhances the pH stability and extends the working range. If data integrity and high productivity are top priorities for your lab, then this column can support your needs for any application.
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|Inner Diameter||4.6 mm|
|Particle Size||5.0 µm|
|Product Brand Name||Quasar|
Glucocorticoid steroids work by suppressing various aspects of the human immune system in conditions where hyperactivity can cause poor health through allergies, inflammation and autoimmune dysfunction. Betamethasone dipropionate belongs to this class of steroids. It is used for its high potency as an anti-inflammatory and immunosuppressant in the treatment of diseases such as eczema, dermatitis and psoriasis. Betamethasone dipropionate is classified as a ‘super-potent’ steroid in the treatment of psoriasis in comparison with betamethasone valerate (another common analogue of betamethasone) which is rated as upper mid-strength. This application brief describes the use of a Quasar C18 column for the analysis of betamethasone dipropionate in accordance with the official USP monograph.
Fluconazole is an azole anti-fungal medication used primarily in the treatment of a wide range of fungal infections. Examples include thrush, urinary tract infections and the prevention of fungal infections in immunocompromised patients undergoing chemotherapy. The mechanism of action can be described as fungistatic, the growth and replication of fungi is inhibited by fluconazole rather than directly attacked. This process is achieved by inhibiting enzymes which are important in the production of fungal membranes, allowing the immune system ample opportunity to target and degrade the pathogen. Fluconazole has generic status and is thus globally produced and prescribed. It is on the World Health Organization’s (WHO) list of essential medicines, which serves as a model of the safest and most effective medications needed by a health system. This application brief describes the use of a Quasar C18, on both porous silica and SPP silica phases, for the analysis of fluconazole in accordance with the official USP monograph.
Ibuprofen belongs to the class of compounds known as Nonsteroidal Anti-inflammatory Drugs (NSAIDS) which are used in the treatment of pain, fever and various types of inflammation. NSAIDS work by inhibiting the synthesis of a wide range of prostaglandins produced as a response to injury, strain or illness. Since its introduction in 1969, its tolerability and effectiveness have made it one of the most popularly prescribed/taken medications in the world, with over 24 million prescriptions in the U.S. alone. Ibuprofen has generic status with many manufacturers, making it a very commercially important compound. Projections have estimated a global market value of ibuprofen to be 294.4 million USD in 2020, with an estimated value of 447.6 million USD by 2026. This application brief describes the use of a Quasar C18, on both porous silica and SPP silica phases for the analysis of ibuprofen in accordance with the official USP monograph, specifically, the chromatographic purity section.
Metformin belongs to a class of drugs known as biguanides and contains the active ingredient metformin hydrochloride. Metformin oral tablets are used, in combination with diet and exercise, to treat high blood glucose levels in patients with type 2 diabetes mellitus. Tablets are often used as monotherapy, or in combination with other anti-diabetic agents or insulin.
This application brief describes the use of a Quasar C18 column for the analysis of metformin hydrochloride RS in accordance with Dissolution Test 3 in the United States Pharmacopoeia (USP) monograph for metformin hydrochloride tablets.
Retinol, one of the main forms of vitamin A, is regularly used in the treatment and protection of skin. By inducing the biosynthesis of collagen and promoting skin cell production, retinol helps to reduce the signs of early UV-induced skin aging. Retinol is also an anti-oxidant, allowing it to neutralize free radicals that may damage healthy skin cells. HPLC with UV detection is commonly used to assess and quantify retinol in a variety of samples.3 This application brief describes the use of a Quasar C18 column for the rapid analysis of retinol.
The most commonly used LC reversed-phase alkyl bonded stationary phase is octadecyl carbon chain (C18)-bonded silica, which is denoted as USP classification L1. C18 columns have a broad applicability from pharmaceuticals to food and environmental analyses. However, not all C18 columns are alike. Simply swapping a C18 column from one manufacturer to another can result in differences in retention time, resolution and even selectivity. Differences can arise due to variations in hydrophobicity, silanol activity, packing quality, particle size distribution, and silica purity, to name a few.
This technical note provides details of a comparative study between twenty-four silica-based C18 phases, from a number of manufacturers covering the following areas: