PerkinElmer
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100 mm, 2.1 mm I.D., 1.7 Quasar C18 LC Column

Quasar C18 LC columns, based on ultra high purity silica and manufactured to tight specification, provides high efficiency separations and excellent peak shape for a wide range of compounds. Our methodology to yield high surface coverage enhances the pH stability and extends the working range. If data integrity and high productivity are top priorities for your lab, then this column can support your needs for any application.

Part Number
Particle Size
Length
Inner Diameter
List Price
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N9308800
5.0 µm
300.0 mm
3.9 mm
605.00 USD
 
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N9308801
5.0 µm
250.0 mm
4.6 mm
594.00 USD
 
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N9308802
5.0 µm
150.0 mm
4.6 mm
588.00 USD
 
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N9308803
5.0 µm
100.0 mm
4.6 mm
583.00 USD
 
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N9308804
5.0 µm
50.0 mm
4.6 mm
577.00 USD
 
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N9308805
3.0 µm
150.0 mm
4.6 mm
616.00 USD
 
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N9308806
3.0 µm
100.0 mm
4.6 mm
611.00 USD
 
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N9308807
3.0 µm
50.0 mm
4.6 mm
605.00 USD
 
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N9308808
3.0 µm
150.0 mm
3 mm
616.00 USD
 
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N9308809
3.0 µm
100.0 mm
3 mm
611.00 USD
 
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N9308810
3.0 µm
50.0 mm
3 mm
605.00 USD
 
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N9308811
3.0 µm
150.0 mm
2.1 mm
616.00 USD
 
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N9308812
3.0 µm
100.0 mm
2.1 mm
611.00 USD
 
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N9308813
3.0 µm
50.0 mm
2.1 mm
605.00 USD
 
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N9308814
1.7 µm
100.0 mm
4.6 mm
667.00 USD
 
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N9308815
1.7 µm
50.0 mm
4.6 mm
667.00 USD
 
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N9308816
1.7 µm
100.0 mm
3 mm
667.00 USD
 
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N9308817
1.7 µm
50.0 mm
3 mm
667.00 USD
 
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N9308818
1.7 µm
100.0 mm
2.1 mm
667.00 USD
 
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N9308819
1.7 µm
50.0 mm
2.1 mm
667.00 USD
 
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Overview

Specifications

Inner Diameter 2.1 mm
Length 100.0 mm
Particle Size 1.7 µm
Product Brand Name Quasar
Type C18
Resources, Events & More
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Application Brief

HPLC Analysis of Betamethasone Dipropionate Using a Quasar C18 Column in Accordance with the United States Pharmacopeia

Glucocorticoid steroids work by suppressing various aspects of the human immune system in conditions where hyperactivity can cause poor health through allergies, inflammation and autoimmune dysfunction. Betamethasone dipropionate belongs to this class of steroids. It is used for its high potency as an anti-inflammatory and immunosuppressant in the treatment of diseases such as eczema, dermatitis and psoriasis. Betamethasone dipropionate is classified as a ‘super-potent’ steroid in the treatment of psoriasis in comparison with betamethasone valerate (another common analogue of betamethasone) which is rated as upper mid-strength. This application brief describes the use of a Quasar C18 column for the analysis of betamethasone dipropionate in accordance with the official USP monograph.

PDF 546 KB
HPLC Analysis of Finasteride using a Quasar C18 Column in Accordance with the United States Pharmacopeia

Finasteride is an antiandrogenic compound or ‘testosterone blocker’ which is used as a treatment for an enlarged prostate and can treat male hair loss. It inhibits the production of the enzyme Type-II 5a-reductase which converts testosterone into the more active metabolite 5a-dihydrotestosterone (DHT). DHT is responsible for the development and enlargement of the prostate and can contribute to hair loss by shortening hair follicles and causing them to fall out more quickly. By suppressing production of DHT, finasteride directly targets the molecule responsible for stimulation of prostatic growth. Finasteride is commonly sold under the brand name Proscar and in 2016 was the 75th most prescribed drug in the USA. This application brief describes the use of a Quasar C18 column to analyze finasteride in accordance with the official Finasteride Tablets USP monograph.

PDF 843 KB
HPLC Analysis of Fluconazole Using Quasar C18 Columns in Accordance with USP Application Brief

Fluconazole is an azole anti-fungal medication used primarily in the treatment of a wide range of fungal infections. Examples include thrush, urinary tract infections and the prevention of fungal infections in immunocompromised patients undergoing chemotherapy. The mechanism of action can be described as fungistatic, the growth and replication of fungi is inhibited by fluconazole rather than directly attacked. This process is achieved by inhibiting enzymes which are important in the production of fungal membranes, allowing the immune system ample opportunity to target and degrade the pathogen. Fluconazole has generic status and is thus globally produced and prescribed. It is on the World Health Organization’s (WHO) list of essential medicines, which serves as a model of the safest and most effective medications needed by a health system. This application brief describes the use of a Quasar C18, on both porous silica and SPP silica phases, for the analysis of fluconazole in accordance with the official USP monograph.

PDF 1 MB
HPLC Analysis of Ibuprofen Using Quasar C18 Columns in Accordance with the United States Pharmacopeia

Ibuprofen belongs to the class of compounds known as Nonsteroidal Anti-inflammatory Drugs (NSAIDS) which are used in the treatment of pain, fever and various types of inflammation. NSAIDS work by inhibiting the synthesis of a wide range of prostaglandins produced as a response to injury, strain or illness. Since its introduction in 1969, its tolerability and effectiveness have made it one of the most popularly prescribed/taken medications in the world, with over 24 million prescriptions in the U.S. alone. Ibuprofen has generic status with many manufacturers, making it a very commercially important compound. Projections have estimated a global market value of ibuprofen to be 294.4 million USD in 2020, with an estimated value of 447.6 million USD by 2026. This application brief describes the use of a Quasar C18, on both porous silica and SPP silica phases for the analysis of ibuprofen in accordance with the official USP monograph, specifically, the chromatographic purity section.

PDF 499 KB

Application Note

Comparison of Clotrimazole HPLC Analysis Using Quasar C18 and Inertsil ODS-3 Columns

Clotrimazole is an azole anti-fungal medication used primarily in the treatment of a wide range of fungal dermal infections. Examples include thrush, athlete’s foot and ringworm. It has limited oral absorption and is commonly available in various topical preparations, including creams, lotions, and solutions. As well as its anti-fungal activity, clotrimazole has become a drug of interest in the treatment of sickle cell disease, malaria and some cancers. Clotrimazole has generic status and is thus globally produced and prescribed. It is on the World Health Organization’s (WHO) list of essential medicines, which serves as a model of the safest and most effective medications needed by a health system. This application brief describes the use of a PerkinElmer Quasar C18 (150 x 4.6 mm, 5 µm) column in comparison with a GL Sciences Inertsil ODS-3 (150 x 4.6 mm, 5 µm) column for the analysis of clotrimazole, conducted by a pharmaceutical company in Chile.

PDF 846 KB
HPLC Analysis of Metformin Using a Quasar C18 Column with USP

Metformin belongs to a class of drugs known as biguanides and contains the active ingredient metformin hydrochloride. Metformin oral tablets are used, in combination with diet and exercise, to treat high blood glucose levels in patients with type 2 diabetes mellitus. Tablets are often used as monotherapy, or in combination with other anti-diabetic agents or insulin.

This application brief describes the use of a Quasar C18 column for the analysis of metformin hydrochloride RS in accordance with Dissolution Test 3 in the United States Pharmacopoeia (USP) monograph for metformin hydrochloride tablets.

PDF 1 MB
Rapid HPLC Analysis of Retinol Using a Quasar C18 Column

Retinol, one of the main forms of vitamin A, is regularly used in the treatment and protection of skin. By inducing the biosynthesis of collagen and promoting skin cell production, retinol helps to reduce the signs of early UV-induced skin aging. Retinol is also an anti-oxidant, allowing it to neutralize free radicals that may damage healthy skin cells. HPLC with UV detection is commonly used to assess and quantify retinol in a variety of samples.3 This application brief describes the use of a Quasar C18 column for the rapid analysis of retinol.

PDF 629 KB

Technical Note

A Comparison of Fully Porous C18 Reversed Phase HPLC Columns Technical Note

The most commonly used LC reversed-phase alkyl bonded stationary phase is octadecyl carbon chain (C18)-bonded silica, which is denoted as USP classification L1. C18 columns have a broad applicability from pharmaceuticals to food and environmental analyses. However, not all C18 columns are alike. Simply swapping a C18 column from one manufacturer to another can result in differences in retention time, resolution and even selectivity. Differences can arise due to variations in hydrophobicity, silanol activity, packing quality, particle size distribution, and silica purity, to name a few.

This technical note provides details of a comparative study between twenty-four silica-based C18 phases, from a number of manufacturers covering the following areas:

  • Relative Hydrophobicity Study
  • Efficiencies for a Neutral Compound
  • Evaluation of Silanol Activity
  • PDF 1 MB
    A Comparison of Quasar C18 and Inertsil ODS-3 HPLC Columns

    The most commonly used LC reversed-phase alkyl bonded stationary phase is octadecyl carbon chain (C18)-bondedsilica, which is denoted as USP classification L1. C18 columns have a broad applicability from pharmaceuticals to food and environmental analyses. However, not all C18 columns are alike. Simply swapping a C18 column from one manufacturer to another can result in differences in retention time, resolution and even selectivity. Differences can arise due to variations in hydrophobicity, silanol activity, packing quality, particle size distribution, and silica purity, to name a few.1

    This technical note provides details of a comparative study between PerkinElmer Quasar™ C18 and GL Sciences Inertsil ODS-3 silica-based columns (150 x 4.6 mm, 5 µm), covering the following areas:

    • Relative Hydrophobicity
    • Efficiencies for a Neutral Compound
    • Evaluation of Silanol Activity
    • Application example – analysis of clotrimazole

    PDF 780 KB