Please enter valid quantity
Please log in to add favorites.
NULL OR EMPTY CART
|Inner Diameter||4.6 mm|
|Particle Size||5.0 µm|
|Product Brand Name||Quasar|
The aerobic mold which yielded cephalosporin C was found in the sea near a sewage outfall nearby Cagliari harbour, Sardinia, by the Italian pharmacologist Giuseppe Brotzu in July 1945. Since their discovery and subsequent commercialization in 1964, the cephalosporins today are broad-spectrum ß-lactam antibiotics used for the treatment of a number of bacterial conditions including septicaemia, pneumonia and meningitis. The pharmacology of cephalosporins is similar to that of the penicillin class of compounds. This application brief describes use of a Quasar biphenyl column in the analysis of several cephalosporins, a mixture of first and second generation ß-lactam antibiotics.
Indoxyl sulfate is one of the most extensively studied solutes that accumulates in the plasma when the kidneys fail. Originally called "indican", it was first isolated by Obermayer and Popper in 1911. High concentrations of indoxyl sulfate in blood plasma are known to be associated with the development and progression of a number of pathological conditions including chronic kidney disease and vascular disease. The scientific literature documents the use of older generation C18 columns, using type A silicas. This application brief will illustrate the application of a new generation C18 column, based on type B silica, for the analysis of indoxyl sulfate, Figure 1, as part of a research study to measure the total levels in a simulated blood serum environment.
Today, Warfarin is the most widely used anticoagulant in the world, used to thin the blood and prevent clots.1 It was discovered by chance when in the 1920’s cattle in the US were found to be bleeding to death having eaten mouldy hay from sweet clover crops.2 However, the exact identity of the substance causing the haemorrhaging was to remain unknown for many years. Over the coming years studies of the spoiled hay eventually led to the extraction of a compound which was later named dicoumarol. It was observed that this dicoumarol could not act as an anticoagulant on its own. It was only after it was metabolised byfungi that it exhibited anticoagulant properties. This explained why only spoiled hay caused the outbreak in the cattle. After further research, the synthesis of a more potent anticoagulant from dicoumarol, warfarin, was produced. Warfarin first commercial use was as a rat poison in 1948, followed by license for human use in 1953. This application brief illustrates the analysis of warfarin, Figure 1, using the Quasar AQ liquid chromatography phase.