PerkinElmer
check quantity

Quantum GX2 microCT Imaging System

Image beyond bone – into oncology, cardiovascular and pulmonary diseases, and much more, with the Quantum GX2 microCT imaging system. With the Quantum GX2, flexibility is key. Combining the ability to perform high speed, low dose scans, ideal for longitudinal studies, across multiple species (mice, rats, rabbits) with high resolution ex vivo scanning, the Quantum GX2 microCT imaging system offers the flexibility and performance you need to not just image, but further understand your disease models.

Part Number CLS149276
Buy Now

Please enter valid quantity

Please log in to add favorites.

NULL OR EMPTY CART

Overview

The Quantum GX2 microCT scanner is a true multispecies preclinical imaging system, offering the flexibility to enable longitudinal in vivo imaging as well as ex vivo sample scanning. With a 163mm imaging bore, an entire rabbit can be placed inside the scanner for in vivo scanning, while the 18mm FOV allows for high resolution scanning of ex vivo samples. Combined with PerkinElmer's 3-dimensional optical imaging systems, and automated bone analysis software (AccuCT), the Quantum GX2 microCT imaging system provides maximal flexibility and function. Whether your research focus is oncology, cardiovascular disease, orthopedics or pulmonary disease, the Quantum GX2 is versatile enough to deliver the results you need.

 

Key Features

  • High resolution (2.3 micrometer voxel size)
  • High-speed (scans as fast as 3.9 seconds)
  • Low-dose imaging for longitudinal in vivo studies
  • Four Field Of Views (FOVs) – 18, 36, 72, and 86 mm
  • Multispecies imaging capabilities (Zebrafish/mouse/rat/guinea pig/rabbit)
  • Two-phase retrospective respiratory and cardiac gating
  • Seamlessly co-registration of functional optical signals (from IVIS® Spectrum or FMT®) with microCT imaging data

Combine the Quantum GX2 microCT imaging with PerkinElmer's other in vivo imaging modalities (optical and PET) to gain greater insight into disease progression and treatment response non-invasively.

Selected Publications

  • Zhao et al (2021). Anti-rheumatoid arthritis effects of iridoid glucosides from Lamiophlomis rotata (Benth.) kudo on adjuvant-induced arthritis in rats by OPG/RANKL/NF-κB signaling pathways. J Ethnopharmacol. 266, 113402.https://doi.org/10.1016/j.jep.2020.113402
  • Kim et al (2021). Heat therapy improves body composition and muscle function but does not affect capillary or collateral growth in a model of obesity and hindlimb ischemia. J Applied Physiol. 130(2): 355-368. https://doi.org/10.1152/japplphysiol.00535.2020
  • van Maldegem er atl (2021). Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow. bioRxiv. https://doi.org/10.1101/2021.02.02.429358
  • Olsen et al (2020). ASCL1 represses a latent osteogenic program in small cell lung cancer in multiple cells of origin. bioRxiv https://doi.org/10.1101/2020.11.11.362632
  • Mecozzi et al (2020). In-vivo lung fibrosis staging in a bleomycin-mouse model: a new micro-CT guided densitometric approach. Sci Rep. 10, 18735. https://doi.org/10.1038/s41598-020-71293-3
  • Imai, M. Kawaoka, Y. et al (2020) Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development. PNAS. https://doi.org/10.1073/pnas.2009799117
  • Wang et al (2020). Exploration and Evaluation of Therapeutic Efficacy of Drug‐Free Macromolecular Therapeutics in Collagen‐Induced Rheumatoid Arthritis Mouse Model. Macromol Biosci. https://doi.org/10.1002/mabi.201900445
  • Eom et al (2020). Abeliophyllum distichum Ameliorates High-Fat Diet-Induced Obesity in C57BL/6J Mice by Upregulating the AMPK Pathway. Nutrients. 12(11), 3320. https://doi.org/10.3390/nu12113320
  • Bader et al (2020). High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages. Oncotarget. 11: 4554-4569. https://doi.org/10.18632/oncotarget.27832
  • Kojonazarov et al (2018). Evaluating Systolic and Diastolic Cardiac Function in Rodents Using Microscopic Computed Tomography. Circulation: Cardiovascular Imaging. 11 (12). https://doi.org/10.1161/circimaging.118.007653
  • Mollaoglu et al (2017). MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. Cancer Cell. 31(2):270-285. https://doi.org/10.1016/j.ccell.2016.12.005

For additional publications, please visit Google Scholar.

Specifications

Height 1450.0 mm
Imaging Modality microCT Imaging
Product Brand Name Quantum
Width 980.0 mm
Resources, Events & More
  • All

Application Note

Assessment of Arterial Function Using MicroCT Imaging

Blood vessel mechanics and function are important aspects of cardiovascular research. Arterial changes have been associated with several pathophysiological conditions, disease states and treatment. Structural components of the arterial vessel wall, smooth vasculature tone, and transmural distendi ...

PDF 995 KB
Contrast-enhanced Imaging of Vasculature and Soft Tissues Using the Quantum GX MicroCT System

X-ray CT imaging is commonly used for skeletal imaging as bones are densely mineralized tissues with excellent x-ray attenuation properties. In contrast, soft, less dense tissues often prove to be challenging to image due to their lack of sufficient tissue density. Soft tissues such as muscle, blood ...

PDF 10 MB
MicroCT Investigation of Bone Erosion and Deformation in an Osteoarthritic Rat Model

Osteoarthritis (OA) is the most common form of arthritis and affects a considerable portion of the elderly population. In the U.S., it is estimated that more than 630 million people worldwide have this chronic condition, generally in the knees. OA occurs when the cartilage that cushions the ends of ...

PDF 1 MB
The Utility of Adeno-Associated Viruses (AAVs) in Therapeutic Approaches for Monogenic Neurological Diseases

Gene therapy is a very powerful tool that is currently being explored to combat disorders with underlying genetic causes. Within the field of neurological diseases, there is great interest looking at rare diseases of monogenic origin with the hope of developing disease-modifying gene therapies, a ...

PDF 454 KB

Article

Editorial: MicroCT in Experimental Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension (PAH) is a life-threatening disease that affects the arteries in the lungs and the right side of the heart. Small animal models are often used in experimental PAH research due to their similarities to human cardiovascular physiology. MRI and microPET are established t ...

PDF 52 KB

Brochure

3D Multimodality Imaging: See disease in all its dimensions

It’s simple: More information means more understanding,For today’s researchers in oncology, infectious diseases, inflammation, neuroscience, stem cells,and other disciplines, there’s an increasing need for in vivo imaging that enables you to visualize,multiple events simultaneously and to extract th ...

PDF 2 MB
Complete Neuroscience Solutions for Research and Discovery

Like the brain, neuroscience has a multitude of layers. Our broad solutions, innovative technologies, and proven expertise help researchers like you understand neurological diseases so that patients can benefit from better treatments and therapies.

PDF 2 MB
Complete Solutions for NASH Research

When Non-alcoholic fatty liver disease (NAFLD) progresses to nonalcoholic steatohepatitis (NASH), with inflammation and damage to liver cells it can cause fibrosis, cirrhosis and liver failure or cancer. Despite the prevalence of NAFLD and NASH rising, their remains no approved treatments. But st ...

PDF 1 MB

Case Study

A Novel Non-Invasive In Vivo Diagnostic Tool for the Assessment of NASH

Non-alcoholic fatty liver disease (NAFLD) describes a progressive pathology that affects the liver. Fat accumulation causes fatty liver (NAFL) or steatosis to develop, which leads to lipotoxicity and in turn induces liver inflammation and apoptosis, resulting in non-alcoholic steatohepatitis (NAS ...

PDF 963 KB
Assessment of MYC-Driven Progression of Small Cell Lung Cancer

Lung cancer is the leading cause of cancer death worldwide with Small Cell Lung Cancer (SCLC), an aggressive form with a typical survival rate of 10-12 months, accounting for roughly 14% of all lung cancers. The primary chemotherapy treatment regimen for SCLC is etoposide plus a platinum-based dr ...

PDF 1 MB

Ebook

In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And ...

PDF 4 MB

Flyer

Guide

IVISense™ Fluorescent Probe Selector Guide for Oncology Research

The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and biological functioning to better understand and characterize disease processes and treatment effects earlier within the context of a biological system.

This s ...

PDF 3 MB

Poster

Quantitative Assessment of Compliance and Resistance in Emphysema Mouse Model Using MicroCT

Emphysema is a form of chronic obstructive pulmonary disease (COPD) most often association with smoking. It is a leading cause of death worldwide and is characterized by irreversible and severe destruction of the alveolar lung sacs. Small animal models are critical to understanding lung disease, ...

PDF 1 MB

Product Note

Regulatory Compliance Certification

Software Downloads

Video Article

White Paper

Assessing Nanomedicine Delivery Across the Blood-Brain Barrier Using Pre-Clinical In Vivo Imaging

We recently spoke to researchers based at the Centre for Advanced Imaging at the University of Queensland in Australia who have been utilizing various pre-clinical in vivo imaging techniques to explore the uptake of custom-designed nanomedicines at different stages of brain cancer.

In this ...

PDF 741 KB
The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick ...

PDF 547 KB