QSight Triple Quad LC-MS/MS 400 Series | PerkinElmer
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QSight LC/MS/MS System

More than ever, laboratories analyzing food and environmental samples are faced with evolving challenges with stricter regulations demanding lower detection limits and higher levels of productivity. Lab operations need to be optimized, without any compromise on analysis confidence and accuracy.

With the PerkinElmer QSight® Triple Quad LC/MS/MS labs can test for the most challenging samples with maximized uptime and confidence. The unique dual-source configuration enables high-throughput labs to collect data in two complementary modes, maximizing the output from a single injection. Combined with the StayClean technology dramatically reduced source cleaning and maintenance, translating into higher productivity and high ROI. Running on the PerkinElmer Simplicity 3Q Software, the PerkinElmer QSight Triple Quad LC/MS/MS is easy-to-learn and use and it is a complete solution streamlining the complete workflow, from validated method development to data reporting.

Part Number
Model Name
BC003844
QSight 420 LC/MS/MS
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BC003382
QSight 220 LC/MS/MS
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BC003383
QSight 210 LC/MS/MS
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BC003265
QSight 110 LC/MS/MS
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Overview

The QSight LC/MS/MS System provides the capability and confidence required to analyze the most complex food and environmental samples. With high level of sensitivity and throughput, laboratories can meet even the most stringent regulatory requirements rapidly, easily, and effectively

  • Sensitivity for the most demanding regulations
  • Easy-to-use with ready to implement methods
  • Patented flow-based technology that enables up to 15% more productivity
  • StayClean Source, self-cleaning design for maximum sensitivity and exceptional uptime
  • Laminar Flow Ion Guide for highly efficient field-free transmission, providing virtually no maintenance requirements
  • Dual Source technology gives you the capability to set ESI or APCI modes, with two independent probes for true multiplexing
  • Modular Simplicity 3Q Software to acquire, quantify, and report with flexible data viewing options and powerful remote diagnostics.
  • Different models available (QSight 110 LC/MS/MS, QSight 210 LC/MS/MS, QSight 220 LC/MS/MS, QSight 420 LC/MS/MS) addressing different levels of performance and efficiency required by different labs’ analysis needs.

Specifications

Model Name QSight 420 LC/MS/MS
Resources, Events & More
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Application Note

A Multiclass Multiresidue Method for Analysis of Veterinary Drugs in Chicken by UHPLC/MS/MS

Veterinary drugs are used in animal production to treat diseases, prevent infection and protect growth of animals, which helps provide quality marketplace. However the uncontrolled use may cause heavy human disease so regulatory agencies around the world have established maximum residue levels (MRLs ...

PDF 1 MB
A Simple and Sensitive Method for Rapid Determination of PFOA and PFOS in Water Samples by Direct Injection UHPLC/MS/MS

Per- and polyfluoroalkyl substances (PFASs), or Per- and polyfluorinated compounds (PFCs), represent a group of anthropogenic chemicals that have been produced and widely used in industrial applications and consumer products since the 1950s. The unique physical and chemical characteristics of these ...

PDF 1 MB
A Single Cannabis Method to Meet California Pesticide and Mycotoxin Residues Regulatory Requirements

Testing for the levels of pesticide and mycotoxins in cannabis is important to ensure consumer safety and quality control. In this work, the PerkinElmer application development team analyzed all 66 pesticides (including very hydrophobic and chlorinated pesticides typically analyzed by GC-MS/MS) and ...

PDF 2 MB
Analysis of Acrylamide in Potato Chips by Isotopically Standard Addition UHPLC-MS/MS

Acrylamide is a probable carcinogen organic compound that is found in some foods that are cooked at elevated temperatures. It’s origins are due to the condensation of the amino acid asparagine and glucose as part of Maillard reaction. In 2002, Acrylamide was found to be present in french fries and b ...

PDF 1 MB
Analysis of Aflatoxins by UHPLC

Aflatoxin B1 is considered to be the most genotoxic of the mycotoxins, and, when ingested by cows, is converted to aflatoxin M1 which has been shown to cause liver cancer in certain animals.

PDF 1 MB
Analysis of Multi-Residue Pesticides in Rice by LC/MS/MS

Due to the large number of pesticides potentially used in rice production, the use of multi-residue methods capable of determining many pesticides in one single run is the most efficient approach. In this study, a fast, sensitive and selective multiresidue method has been developed for analysis of o ...

PDF 1 MB
Analysis of Pesticide Residues in Cannabis Regulated by Oregon State Using LC/MS/MS

Liquid chromatography-tandem mass spectrometry (LC/MS/MS) has become the method of choice for pesticide. The state of Oregon has issued regulatory limits for 59 pesticide residues in both cannabis flower and concentrates, while other states have come up with their own lists of pesticide residues rel ...

PDF 1 MB
Analysis of Pork Adulterated Meat

A selective and sensitive LC/MS/MS method for fast identification and analysis of meat samples using three peptides specific for pork as biomarkers. . The optimized sample preparation procedure is easy to follow and can be used for analyzing raw, cooked and processed meat products. This method can s ...

PDF 1 MB
Analysis of Target Pesticide Residues in Berries with LC/MS/MS Coupled with a QuEChERS Sample Prep

Analysis of target pesticide residues in berries using a unique laminar flow UHPLC-ESI-MS/MS

PDF 1 MB
Analysis of Water-Soluble Vitamins in Infant Formula by UHPLC-MS MS

Water-soluble vitamins (WSV), comprised primarily of the vitamin B complex, are essential ingredients in many foods, particularly in infant formulas. When analyzing fortified foods, this can be particularly challenging due to the wide range in concentration of vitamins, in keeping with daily allowan ...

PDF 1 MB
Analysis of illegal dyes in Chili Spices via UHPLC-MS/MS

Since 2003 the usage of azo and non-azo dyes for food coloring has been declared as illegal by many of the food international authorities across the globe. That is because these substances such as Sudan I,II,III,IV and Rhodamine B, are potentially carcinogens and genotoxin in nature. As of now, no o ...

PDF 4 MB
Analysis of near 400 Pesticides in Tea Via LC/MS/MS

With routine labs tasked with the analysis of larger and larger target lists, and with greater numbers of samples requiring analysis, we deployed simple sample preparation protocols such as solvent extraction to meet the need of high sample throughput with lower cost. In this work, we demonstrate ho ...

PDF 1 MB
Detection of Fipronil and Metabolites in Eggs by LC-MS/MS

Fipronil is a broad-spectrum phenylpyrazole insecticide almost used to protect corps from insects but also to treat lice and ticks in chickens. The U.S. EPA classified fipronil as Group C, possible human carcinogen, therefore International organizations defined admissible limits for the fipronil usa ...

PDF 719 KB
Determination of Aflatoxin M1 in Milk and Infant Formula by QSight LC-MS-MS

Aflatoxin B1 is often found in animal feeds such as corn, cottonseed cake, groundnut meal, and other agricultural commodities. When these contaminated feeds are ingested by milk-producing animals, such as cattle, aflatoxin B1 can be converted to aflatoxin M1 (a hydroxy derivate of aflatoxin B1) by o ...

PDF 949 KB
Determination of Antibiotics and Veterinary Drugs in Milk by QSight LC/MS/MS

In this study we show two methods for the analysis of over 30 antibiotics and veterinary drugs in milk regulated by the Food Safety and Standards Authority of India (FSSAI). For polar analyte analysis, such as aminoglycoside antibiotics (apramycin, spectinomycin, and neomycin) in milk, a mixed mode ...

PDF 985 KB
Determination of Sulfonamides in Honey

In apiculture, sulfonamides are the most commonly used antibiotics to treat American and European Foulbrood, a type of disease that infects bees. This application note demonstrates how QSight 200 System can provides a very sensitive and robust platform for the analysis of sulfonamides in honey.

PDF 1 MB
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High Sensitivity Analysis of Estrogens in Water and Urine by Direct Injection UHPLC/MS/MS

Estrogen plays an important role in the human body, but excess concentrations of endogenous estrogens, a known endocrine disrupting compound (EDC), in urine have been linked to the development and growth of breast cancer and tumors in females. Endogenous estrogens, including estrone (E1), 17ß-estrad ...

PDF 1 MB
LC/MS/MS Analytical Method for Pesticide Residue in Cannabis Flower as Defined by Florida Testing Requirements

This application note outlines a new workflow with one instrument platform (LC/MS/MS) method that is ideal for simultaneous analysis of pesticide and mycotoxins residue in cannabis. This application note demonstrates the performance of a LC/MS/MS ESI and APCI method with a single solvent extraction ...

PDF 2 MB
LC/MS/MS: Analysis of Alkylphenol Ethoxylates (APEO) And Alkylphenols (AP) In Textiles

Alkylphenol ethoxylates (APEOs) are common surfactants used in in industrial and consumer detergents and cleaners, as well plastics and many industrial applications. Nonylphenol ethoxylates (NPEOs) belong to the group of non-ionic surfactants and are of particular interest, as they tend to degrade t ...

PDF 2 MB
LC/MS/MS: Determination of Nitrosamines in Tobacco Products

Tobacco specific nitrosamines (TSNA) are a group of chemicals found in tobacco, smokeless tobacco, and tobacco smoke. They are widely considered to be among the most important arcinogens in tobacco products and cigarette smoke. Tobacco product manufacturers must report their contents in tobacco prod ...

PDF 2 MB
Measurement of Remdesivir & Its Metabolite GS-441524 in Plasma

Sensitive and accurate determination of remdesivir and GS-441524 in human plasma samples for pharmacokinetic and pharmacodynamic studies of remdevisir.

PDF 599 KB
Meeting Canadian Cannabis Pesticide Residues Regulatory Requirements by LC/MS/MS

Following the 2018 legalization of recreational cannabis usage in Canada, the quality and safety of cannabis products has garnered significant attention. Health Canada has developed a regulatory program mandating pesticide testing on all cannabis products. Under the program, licensed producers (LPs) ...

PDF 1 MB
Novel ESI and APCI LC/MS/MS Method for Testing Cannabis and Hemp Concentrate Samples

The use of cannabis concentrates and CBD products (edibles, topicals, vape products, etc.) has increased in popularity as new regulation has been passed legalizing medicinal and recreational use in a number of states and provinces. Testing to ensure that pesticide and mycotoxin levels in cannabis pr ...

PDF 1 MB
Pesticide in Grapes by LC-MS/MS

The Grape crop is one of the most important fruit crops consumed in the world. Grapes are consumed both as fresh and as processed products, such as wine, jam, juice, jelly, grape seed extract, raisins, vinegar and grape seed oil. A large variety of pesticides are used in grape production throughout ...

PDF 1 MB
Quantitation of Microcystins and Nodularin in Drinking Water Samples to Meet EPA Method 544 Requirements Using QSight LC/MS/MS

Cyanotoxins often exist intracellularly in cyanobacteria and are released into the water when cells die. Blooms caused by cyanobacteria can be harmful to the human health, animals, and the environment. Microcystin-LR (MC-LR) is one of the most common cyanotoxins and ingestion will cause negative hum ...

PDF 901 KB
Rapid Analysis of Haloacetic Acids in Drinking Water Using UHPLC/MS/MS

Haloacetic acids (HAAs) are a class of undesired by-products resulting from the reaction of chlorinated disinfectants with natural organic matter in water, Which is known to be carcinogenic. The Japan Ministry of Health revised the inspection method for HAAs, which led to expansion of the analytical ...

PDF 1 MB
Simple and Sensitive Method for Determination of Ochratoxin A in Wine by LC/ MS Using QSight Technology

Ochratoxin A (OTA) is a secondary metabolite produced by Penicillium and Aspergillus fungi species found in soil and organic matter, and is one of the most widely reported of the nearly 400 recognized mycotoxin contaminants of agricultural products. OTA can enter the human food chain through contami ...

PDF 924 KB
Simultaneous Determination of Pesticides Residues and Illegal Additives in Wine

Wine can often contain pesticides and fungicides that have been sprayed on the fruits during their growing period. In addition to these contaminants, wine can also contain additives that have been deliberately added during production processes to improve its flavor and color. In this study, a simple ...

PDF 1006 KB
Simultaneous Determination of Plant Growth Regulators in Bean Sprouts

A simple and sensitive method for the simultaneous determination of plant growth regulators

PDF 2 MB

Ebook

What's in Your Water? PFAS Analysis Explained

Over the past decade, awareness and concern about Per- and Polyfluoroalkyl Substances (PFAS) has grown and led to more in-depth analysis of these compounds and the effects that they can have on human health. Due to their inert nature, PFASs are persistent organic pollutants and have been found to ac ...

PDF 1 MB

Guide

Tips for Launching a Modern Cannabis Testing Lab

Demand for cannabis testing services continues to climb as more US states and countries around the globe implement regulated adult-use markets. The cannabis testing sector in the US, like many facets of the cannabis industry, is challenged by the complexity of working with a federally illegal but st ...

PDF 285 KB

Poster

Advanced Solutions for Polymers and Plastics

This poster lays out our whole material characterization range for the analysis of polymers and plastics. Find ideal techniques and instruments at each stage in the polymer manufacturing process: Resin Development - Resin Manufacture - Compound Development - Compound Manufacture - Product Forming - ...

PDF 2 MB

Regulatory Compliance Certification

Technical Note

Ion Transmission Through a Quadrupole Ion Guide

Ion Transmission Through a Quadrupole Ion Guide Under the Combined Influence of Viscous Flow and RF

PDF 1 MB
Theoretical Studies of Swirling Flow and Heating Methods

Theoretical Studies of Swirling Flow and Heating Methods on Droplet Evaporation in a Heated Coaxial

PDF 503 KB

Video

From Contamination to Productivity: PerkinElmer StayClean Technology

Analytical laboratories face many challenges when analyzing contaminants such as Pesticides, PFAS, mycotoxins in complex matrices. These samples often require time-consuming sample prep and regular maintenance of the analytical technology.

Video
Overcoming PFAS Challenges - Method Development for Changing PFAS Regulations

Due to PFAS persistence in the environment and potential health risks, regulations have been undergoing constant change and refinement.

Video
Customer Spotlight: Pride Analytics

With our extended portfolio of cannabis testing products featuring best-in-class sample homogenization platforms, ICP-MS, LC/MS-MS, Headspace-GCMS, UHPLC and FTIR instruments and consumables, we help drive analytical best practices and operating procedur

Video
Overcoming PFAS Challenges – Mitigating Matrix-Induced Ion Source Contamination

PFAS matrix-induced contamination poses various challenges for analytical laboratories, from the risk of achieving low detection limits and lab downtime.

Video
Overcoming PFAS Challenges - Minimizing Sources of Contamination

PFAS compounds are ubiquitous throughout the environment and accumulate everywhere, including in the lab.

Video
Mitigate Interference and Contamination in PFAS Analysis

As per- and polyfluoroalkyl compounds become more prominent, the US Environmental Protection Agency (EPA) are developing more stringent regulations for PFAS monitoring.

Video
Efficient, Robust and reliable performance for LC/MS/MS Analysis

Stricter regulations demanding lower detection limits, increased throughput and efficiency demand that labs need an LC/MS/MS solutions that offers robust and reliable performance while ensuring efficiencies.

Video
Analyzing the Unanalyzable: Breakthrough in Complex Samples with LC/MS/MS

When examining complex compounds like PFAS, pesticides, and mycotoxins using LC/MS/MS in challenging matrices, laboratories encounter issues such as system contamination, matrix effects, and the laborious task of source cleaning.

Video
Customer LC/MS/MS Spotlight: Professor Sabra Botch-Jones

The PerkinElmer QSight LC/MS/MS is used for many applications, including forensic toxicology.

Video

Webinars

LC-MS Tips & Tricks

In this presentation, prepare to learn all of the best practices for Liquid Chromatography Mass Spectrometry from consumables all the way to instrumentation and analysis. This talk is well-suited for all LC/MS applications including environmental testing

Webinars
Analysis of 102 Pesticide and 5 Mycotoxin Residues In Hemp Regulated By Colorado State

In this latest webinar, LC–MS/MS PerkinElmer expert Dr. Avinash Dalmia describes how LC–MS/MS based systems and methods can overcome the challenges associated with the analysis of pesticides and mycotoxins regulated by Colorado state in hemp with dual ES

Webinars
What’s in Your Water? Monitoring Cyanotoxins in Drinking Water by LC-MS/MS

Growing environmental concern has led to stricter regulations of drinking water and water supplies over the past decade including routine monitoring and detection of cyanotoxins resulting from ever-growing algae blooms. This talk discusses the utiliza

Webinars
Critical Insights in the Detection of PFAS in our Environment

PerkinElmer offers a portfolio of high-performance solutions to optimize your laboratory workflow for PFAS analysis.

Webinars
What’s in Your Water? Monitoring Pharmaceuticals and Personal Care Products in Drinking Water by LC-MS/MS

Pharmaceutical and personal care products (PPCPS) are an emerging environmental concern and include human and veterinary prescriptions, over-the-counter medications, sunscreens, lotions, soaps and insect repellents. In this webinar we demonstrate the a

Webinars
QSight LC-MS/MS in Toxicology Research at Boston University

In this podcast, we meet with Simone Rumph, a first generation college student, to discuss her research on post-mortem drug identification.

Webinars
Optimizing Workflow and Efficiency in the Analysis of Emerging Contaminants, Including PPCPs and PFAS

Emerging contaminants, including perfluoroalkyl surfactants (PFAS) and Pharmaceuticals and Personal Care Products (PPCPs), have garnered increasing interest in recent years as their bioaccumulative nature and endocrine disrupting potential have become..

Webinars
Complex Matrices: How the PerkinElmer QSight LC/MS/MS can help tackle the toughest samples

When it comes to analyzing environmental or food samples, including water, soil, cannabis or any solid matrices, labs need to meet stricter regulations that demand lower detection limits.

Webinars
What’s in your Water? Monitoring of PFAS in Drinking Water According to EPA Method 537.1

The US EAP Method 537.1 is used for the determination of selected PFASs in drinking water by solid phase extraction and liquid chromatography/tandem mass spectrometry. This talk discusses the utilization of the PerkinElmer QSight® Triple Quadrupole LC

Webinars

White Paper

Mitigation of PFAS in Drinking Water Through Analytical Innovation

Per- and polyfluoroalkyl substances (PFAS) have gained significant attention as an emerging environmental and safety threat in the United States. Since the 1940s, PFAS are ubiquitous in industrial usage due to their chemical stability, thermal stability, and high resistance to degradation. Bioaccumu ...

PDF 900 KB