Ideal for analyzing food, cannabis, and environmental samples, our robust and reliable QSight® triple quad systems consistently deliver the throughput and productivity you need in your analytical testing lab. Now we’ve added the premier model to our QSight family: the high performance 400 series. This ready-to-implement solution has the highest sensitivity and throughput the industry has ever seen and the capability to test for the most challenging, complex samples, including cannabis.
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For routine analysis of everyday samples in simpler matrices, our QSight 100 series triple quad delivers rugged high performance, linearity, and sensitivity in an affordable, compact footprint. This is your everyday partner for confident quantification.
Achieve the highest levels of performance from sample handling right through final results and reporting with QSight triple quad LC/MS/MS systems.
|Model Name||QSight 100 Series|
Mycotoxins are toxic secondary metabolites produced by various fungal species growing in foods and animal feeds. To minimize risk and protect consumers, mycotoxin levels in foods and/or feeds have been regulated by agencies in many countries around the world. A number of analytical methods for the determination of mycotoxins have been utilized in the past, however LC/MS/MS method has become the method of choice for quantification and confirmation of mycotoxins in various food sample matrices owing to its superior sensitivity, selectivity and capability of analyzing multiple target mycotoxins in a single run.
In this application note, a method for the analysis of 12 mycotoxins in a number of common food matrices (yellow corn, white corn, wheat, soybean, almond, oat breakfast cereal, and peanut butter) utilizing a QSight 220 LC/MS is presented. A stable isotope dilution assay (SIDA) technique is used, which has been proven to be the most effective and preferred calibration approach for mycotoxin analysis in complex sample matrices because it can not only compensate for sample matrix effects, but also minimize variations in analytical procedures.
Veterinary drugs are used in animal production to treat diseases, prevent infection and protect growth of animals, which helps provide quality marketplace. However the uncontrolled use may cause heavy human disease so regulatory agencies around the world have established maximum residue levels (MRLs) or tolerances of veterinary drugs in foods. Drug analysis is generally challenging, due to the complexity of sample matrices and diversity of analytes from various classes of chemical properties. In this study, a fast, sensitive and selective method has been developed for analysis of 73 veterinary drugs (covering 13 different chemical classes) in chicken samples by coupling solvent extraction method with LC/MS/MS.
A New, Sensitive Method for Lignan Metabolite Detection of Flaxseed-Fed Mice Using LC/MS/MS
Testing for the levels of pesticide and mycotoxins in cannabis is important to ensure consumer safety and quality control. In this work, the PerkinElmer application development team analyzed all 66 pesticides (including very hydrophobic and chlorinated pesticides typically analyzed by GC-MS/MS) and five mycotoxins spiked in cannabis flower extracts well below the action limits specified by the state of California. A LC-MS/MS instrument was used with ESI and APCI sources and a simple solvent extraction method with excellent recoveries for all analytes in acceptable range of 70-120%.
Acrylamide is a probable carcinogen organic compound that is found in some foods that are cooked at elevated temperatures. It’s origins are due to the condensation of the amino acid asparagine and glucose as part of Maillard reaction. In 2002, Acrylamide was found to be present in french fries and baked bread. This compound has now also been found in some other food stuff like coffee, black olives, dried pears, and peanuts. As a result the and World Health Organizations have promptly limited its presence for human consumption.
Aflatoxin B1 is considered to be the most genotoxic of the mycotoxins, and, when ingested by cows, is converted to aflatoxin M1 which has been shown to cause liver cancer in certain animals.
Due to the large number of pesticides potentially used in rice production, the use of multi-residue methods capable of determining many pesticides in one single run is the most efficient approach. In this study, a fast, sensitive and selective multiresidue method has been developed for analysis of over 200 pesticides in rice samples by coupling a modified QuEChERS extraction method with LC-MS/MS. Using time-managedMRM™ in the QSight® triple quadrupole mass spectrometer, the optimum dwell time of multiple MRM transitions can be generated automatically for the targeted analytes.
Mycotoxins produced by fungi as toxic secondary metabolites, leave grains, maize and cereals particularly vulnerable. With this in mind, and considering that an estimated 25% of all crops show some signs of mycotoxin contamination, many countries have established regulatory guidelines for maximum mycotoxin limits in not only feed and grain, but also in processed food products.
Liquid chromatography-tandem mass spectrometry (LC/MS/MS) has become the method of choice for pesticide. The state of Oregon has issued regulatory limits for 59 pesticide residues in both cannabis flower and concentrates, while other states have come up with their own lists of pesticide residues relating to medical marijuana and cannabis testing.
Analysis of target pesticide residues in berries using a unique laminar flow UHPLC-ESI-MS/MS
Water-soluble vitamins (WSV), comprised primarily of the vitamin B complex, are essential ingredients in many foods, particularly in infant formulas. When analyzing fortified foods, this can be particularly challenging due to the wide range in concentration of vitamins, in keeping with daily allowances. This application note presents a LC-MS/MS method for the efficient, routine and robust chromatographic analysis of B-vitamins in infant formula. Eight water soluble vitamins over a wide concentration range were identified and quantified in under four minutes. The results showed excellent retention time repeatability and the method was able to detect vitamin B12 at 0.5 ppb, well below the expected level of ~2 ppb in infant formulas.
Since 2003 the usage of azo and non-azo dyes for food coloring has been declared as illegal by many of the food international authorities across the globe. That is because these substances such as Sudan I,II,III,IV and Rhodamine B, are potentially carcinogens and genotoxin in nature. As of now, no official methods have been published for the detection of illegal dyes however, the most used analytical technology is GC-MS or HPLC coupled with UV or MS detection.
Fipronil is a broad-spectrum phenylpyrazole insecticide almost used to protect corps from insects but also to treat lice and ticks in chickens. The U.S. EPA classified fipronil as Group C, possible human carcinogen, therefore International organizations defined admissible limits for the fipronil usage which in egg is of 5 µg/L4. LC-MS/MS technology can provide a robust and reliable method to detect such a contaminant in food.
Aflatoxin B1 is often found in animal feeds such as corn, cottonseed cake, groundnut meal, and other agricultural commodities. When these contaminated feeds are ingested by milk-producing animals, such as cattle, aflatoxin B1 can be converted to aflatoxin M1 (a hydroxy derivate of aflatoxin B1) by oxidation metabolism, and then excreted in milk. To protect consumers from the potential toxicity and carcinogenicity of aflatoxin M1, regulatory agencies have established regulatory limits or action levels for aflatoxin M1 in milk products.
In this study, a simple, fast, selective and sensitive LC/MS/MS method for the analysis of aflatoxin M1 is presented, along with the evaluation of three sample preparation methods.
In this work, we present a fast and sensitive LC/MS/MS method
Glyphosate is a very polar compound with high solubility in water and low solubility in most organic solvents and, as such, requires methods based on derivatization which are labor-intensive and time consuming. The present work shows a 12 minute LC-MS/MS method with an amino-based column to analyze glyphosate and other related polar compounds in underivatized states, with exceptional selectivity and sensitivity.
The Grape crop is one of the most important fruit crops consumed in the world. Grapes are consumed both as fresh and as processed products, such as wine, jam, juice, jelly, grape seed extract, raisins, vinegar and grape seed oil. A large variety of pesticides are used in grape production throughout its growing season to control pests and diseases in vineyards and to increase crop yield. Pesticide residue is a major concern for the stakeholders of the grape industry, due to more and more stringent regulations and safety standards in most countries.
Haloacetic acids (HAAs) are a class of undesired by-products resulting from the reaction of chlorinated disinfectants with natural organic matter in water, Which is known to be carcinogenic. The Japan Ministry of Health revised the inspection method for HAAs, which led to expansion of the analytical technique to include LC/MS/MS) as an alternative to the GC-MS method.
Cartridges containing cannabis extract or CBD are some of the cannabis industry’s fastest-growing major product categories. It is imperative that the composition of these products is understood to ensure that components in the product do not contribute to e-cigarette or vaping product use-associated lung injury (EVALI). Vitamin E acetate, often used as a thickening agent in the production of vape oils obtained in the illicit market, has been suggested to be a cause for EVALI.
In this application note, an LC/MS/MS method for the determination of vitamin E acetate (tocopherol acetate) in vape oil cartridges is presented. The method, which quantifies vitamin E acetate in less than three minutes utilizing a QSight® 420 triple quadrupole system, addresses the diversity and complexity of the cannabis and CBD matrix which have historically resulted in interferences that prevent rapid and accurate analysis.
Ochratoxin A (OTA) is a secondary metabolite produced by Penicillium and Aspergillus fungi species found in soil and organic matter, and is one of the most widely reported of the nearly 400 recognized mycotoxin contaminants of agricultural products. OTA can enter the human food chain through contaminated feed, primarily cereal-based, that is ingested by animals that are farmed for human consumption. OTA can also be found in wine owing to contamination of grapes by some species of Aspergillus, in particular, the strains of A. carbonarius and A. niger.
In this work, a rapid and sensitive analytical method for the determination of the extent to which OTA residues contaminate wine is presented. Utilizing a QSight 220 with both ESI and APCI ionization sources, OTA is detected and quantified in both red and white wine samples at two concentration levels - 0.5 and 2 µg/L.
This application note presents a sensitive and reliable LC/MS/MS method using the PerkinElmer QSight
Wine can often contain pesticides and fungicides that have been sprayed on the fruits during their growing period. In addition to these contaminants, wine can also contain additives that have been deliberately added during production processes to improve its flavor and color. In this study, a simple and sensitive LC-MS/MS method has been developed and applied for the determination of both pesticides and pigments in a single analytical run.
A simple and sensitive method for the simultaneous determination of plant growth regulators
In this study, the QSight LC-MS/MS system was used to evaluate the potential of eliminating sample preparation for trace level pesticide analysis in a complex sample such as wine. We injected undiluted red and white wine samples into the mass spectrometer and studied reproducibility in analysis of the spiked pesticides over 200 injections. The instrument showed excellent reproducibility with minimal signal drift during the duration of the study (over a week), confirming the robustness of the QSight mass spectrometer.
Whether your lab is well established or just starting up, having a single-source partner who can offer turnkey solutions that meet the current regulations is essential to a successful business. For years, we’ve worked with government and contract cannabis laboratories to develop industry-leading methods, technology, and exceptional return on investment. We help drive analytical standards and commit to ensuring your laboratory has maximum uptime. Learn about our various testing methods and applications for cannabis analyses. Let us work with you to build an efficient workflow, so you can focus on growing your business and brand.
The grain industry is very complex. It’s global, diverse, and can also present analytical challenges. Today’s grain users demand more when it comes to quality, safety, and uniformity. In addition, they seek diverse products with unique characteristics.
PerkinElmer is equipped to help the grain industry in its quest to feed the world – nutritiously and economically. Our testing and analysis solutions encompass the three primary areas required for complete knowledge of grains and their derivatives – composition, functionality, and safety.
Food testing labs like yours are constantly challenged with accurately analyzing samples quickly and efficiently - all while striving to reduce costs due to market forces. Your commitment to ensuring meat and seafood are safe for consumption, as demand increases, is an uphill battle.
Our commitment to you: to provide a range of solutions across multiple technologies, products, and services that meets or exceeds the testing needs of food processors. Our solutions offer more efficiency and increased accuracy and sensitivity for better yields in real time with minimal training.
From instrumentation and software to consumables and reagents to service and support, we are dedicated to providing you with end-to-end solutions that ease your everyday challenges of automation, throughput, service, and time to results.
Pesticides can adversely affect human health through the food we consume but can also leach into soil and groundwater and impact us through the environment. To keep up with a complex and constantly changing regulatory environment, your pesticide analysis solution needs to keep up with your burgeoning sample load.
Our QSight triple quad LC/MS/MS family has always been known for its robust and reliable performance. But now there’s something new – something better: the high performance 400 series. Our ready-to-implement solution has the highest sensitivity and throughput the industry has ever seen and the capability to test for the most challenging samples and analytes.
Whether you’re a lab manager or a bench chemist, you know firsthand how things are changing quickly in food and environmental analysis. And your lab needs to change to keep pace.
Today’s advanced and increasingly diverse chromatography laboratories are facing new challenges on a daily basis – starting from raw materials right up to the finished product. Our comprehensive portfolio of analytical solutions is designed to give you the higher accuracy, sensitivity, and ease of use your laboratory demands for examining with confidence, the purity, composition, and performance of your compounds. What’s more, a range of complementary services is available to keep your laboratory up and running, meeting the stringent requirements of a variety of environments and working practices.
Trust the consumables engineered for your instruments.
Whatever your separation challenge, your choice of liquid chromatography (LC) column can make all the difference. Our Quasar portfolio of LC columns combined with the improved work? Workflow and usability of the LC 300 system allows you to achieve rugged and reproducible results. Now, with the purchase of an LC 300 system, you can pick out a Quasar LC column free of charge. Learn more below.
Our QSight triple quad LC/MS/MS family has always been known for its robust and reliable performance. But now there’s something new – something better: the high performance 400 series.
Our modular Simplicity 3Q™ software is ideal for acquiring, quantifying and reporting
Lab reequirements for QSight triple quad LC/MS/MS systems, including storage, suppleis, space, electrical, power, gas supply requirements
Simulation using sophisticated modeling techniques has become a powerful tool for mass spectrometry
Ion Transmission Through a Quadrupole Ion Guide Under the Combined Influence of Viscous Flow and RF
Theoretical Studies of Swirling Flow and Heating Methods on Droplet Evaporation in a Heated Coaxial