PerkinElmer
check quantity

PK 11195, [N-Methyl-3H]-, 250µCi (9.25MBq)

PK-11195, tritiated on the N-methyl group. PK-11195 binds selectively to the peripheral benzodiazepine receptor (PBR).

You successfully added item(s) to your cart

Part Number
Unit Size
List Price
Your Price
Quantity
NET885025UC
25 µCi
606.00 USD
more
NET885250UC
250 µCi
2000.00 USD
more
NET885001MC
1 mCi
4478.00 USD
more
Buy Now

Please enter valid quantity

Please login to add favorites

NULL OR EMPTY CART

Detail Information

PK-11195 acts as an antagonist at peripheral benzodiazepine receptors (PBRs), and is used as a marker of neuronal damage in animal models of central nervous system (CNS) damage. PBRs are potential drug targets for cancer, autoimmune, infectious disease, and neurodegenerative disease.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET885:

  1. V Papadopoulos, P Guarneri, K E Kreuger, A Guidotti, and E Costa. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. PNAS, vol. 89, no. 11, 1992, Pages 5113-5117.
  2. Benavides, J., Quarteronet, D., Plouin, P., Imbault, F., Phan, T., Uzan, A., Renault, C., Dubroeucq, M., Gueremy, C., Le Fur, G. Characterization of peripheral type benzodiazepine binding sites in human and rat platelets by using [3H]PK 11195. Studies in hypertensive patients, Biochemical Pharmacology, vol 33, issue 15, 1984, Pages 2467-2472.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 352.5
Radioisotope H-3
Radionuclide 3H
Receptor Type Benzodiazepine, GABAA
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi
Resources, Events & More
  • All

Brochure

Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

PDF 2 MB