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Paroxetine, [Phenyl-6`-3H]-, 250µCi (9.25MBq)

Paroxetine (Paxil), tritiated at the phenyl-6′ position. Paroxetine is a selective serotonin reuptake inhibitor (SSRI).

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25 µCi
753.00 USD
250 µCi
5400.00 USD
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Paroxetine acts as a potent serotonin transporter (SERT) antagonist and a weak norepinephrine transorter (NET) antagonist. It is used to treat depression, obsessive-compulsive disorder, social anxiety disorder, and panic disorder. It is also used to treat symptoms associated with menopause.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET869:

  1. Stain-Malmgren, R., Kjellman, B.F., Åberg-Wistedt, A. (1998), Platelet serotonergic functions and light therapy in seasonal affective disorder, Psychiatry Research, 78 (3): 163-172.
  2. Assié, M.-B. and Koek, W. (1996), Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats. British Journal of Pharmacology, 119: 845–850.


Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 329.4
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Serotonin
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi