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Neurokinin B, [125I]His, MePhe7, 10µCi

Neurokinin B (NKB), labeled with 125I on the histidine residue. Neurokinin B is involved in ovarian cycle regulation, and binds neurokinin 3 receptor (NK3R; tachykinin receptor 3), a GPCR involved in vascular remodeling, angiogenesis, and cancer.

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10 µCi
1987.00 USD
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We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX285:

  1. Singewald, N., Chicchi, G. G., Thurner, C. C., Tsao, K.-L., Spetea, M., Schmidhammer, H., Sreepathi, H. K., Ferraguti, F., Singewald, G. M. and Ebner, K. (2008), Modulation of basal and stress-induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L-822429. Journal of Neurochemistry, 106: 2476–2488.
  2. Borioni, A., Mustazza, C., Sestili, I., Sbraccia, M., Turchetto, L. and Del Giudice, M. R. (2007), Synthesis of New 4-Heteroaryl-2-Phenylquinolines and Their Pharmacological Activity as NK-2/NK-3 Receptor Ligands. Arch. Pharm. Pharm. Med. Chem., 340: 17–25.


Detection Method Radiometric
Fresh Lot Days Third Monday of each month
Label Position Nominally Labeled
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Tachykinin
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Inflammation
Unit Size 10 µCi