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Methylhistamine Dihydrochloride, N-α-[methyl-3H]-, 250µCi (9.25MBq)

(R)-α-methylhistamine dihydrochloride, tritiated on the methyl group. α-Methylhistamine is a histamine agonist selective for the histamine H3 receptor.

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α-Methylhistamine is a selective agonist for the histamine H3 receptor. This receptor is a GPCR that is a potential drug target for central nervous system disorders.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1027:

  1. Griebel, G., Pichat, P., Pruniaux, M., Beeské, S., Lopez-Grancha, M., Genet, E., Terranova, J.P., Castro, A., Sánchez, J.A., Black, M., Varty, G. B., Weiner, I., Arad, M., Barak, S., De Levie, A., Guillot, E. (2012), SAR110894, a potent histamine H3-receptor antagonist, displays procognitive effects in rodents, Pharmacology Biochemistry and Behavior, 102 (2): 203-214.
  2. Jin, C. Y., Kalimo, H. and Panula, P. (2002), The histaminergic system in human thalamus: correlation of innervation to receptor expression. European Journal of Neuroscience, 15: 1125–1138.


Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 198.0
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Histamine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Inflammation
Unit Size 250 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed t ...