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MDL105,519 [3H]

Tritiated MDL 105,519. MDL 105,519 acts as a potent and selective antagonist at N-methyl-D-aspartate (NMDA) receptors.

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MDL105,519 acts as an antagonist at N-methyl-D-aspartate (NMDA) receptors. NMDA receptors are glutamate receptors and ion channel proteins and are potential drug targets for neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1171:

  1. Jungsook Cho, Jae-Yang Kong, Dae-Young Jeong, Kap Duk Lee, Dong-Ung Lee, Byung-Soo Kang, NMDA recepter-mediated neuroprotection by essential oils from the rhizomes of Acorus gramineus, In Life Sciences, Volume 68, Issue 13, 2001, Pages 1567-1573.


Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 376.19
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type NMDA
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed t ...