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Mazindol, [4`-3H]-, 250µCi (9.25MBq)

Mazindol, tritiated at the 4' position. Mazindol has been shown to block dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters.

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NET816250UC
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Detail Information

Mazindol is an inhibitor that has been shown to block dopamine, serotonin, and norepinephrine transporters. Mazindole is an appetite suppressant that is used to treat obesity.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET816:

  1. Raffel, D.M, Chen, W., Jung, Y., Jang, K.S., Gu, G., Cozzi, N.V. Radiotracers for cardiac sympathetic innervation: Transport kinetics and binding affinities for the human norepinephrine transporter, In Nuclear Medicine and Biology (2013) 40 (3): 331-337.
  2. Raffel, D.M. & Chen, W. Binding of [3H]mazindol to cardiac norepinephrine transporters: kinetic and equilibrium studies. Naunyn-Schmiedeberg's Arch Pharmacol (2004) 370: 9.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 284.74
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Dopamine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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