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Lysergic Acid Diethylamide, [N-Methyl-3H]-, 250µCi (9.25MBq)

Lysergic Acid Diethylamide (LSD), tritiated on the N-methyl group. LSD is a partial agonist of dopamine D2 receptors. It also binds most serotonin receptors (5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT5B and 5-HT6). This product has a scheduled lot release for the second Monday in April, August and December.

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Lysergic Acid Diethylamide (LSD) is a psychedelic drug that acts as an agonist at dopamine D2 receptors and serotonin receptors 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT5B and 5-HT6.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET638:

  1. Teresa Riccioni, Fabio Bordi, Patrizia Minetti, Gilberto Spadoni, Hyung-Mun Yun, Bo-Hye Im, Giorgio Tarzia, Hyewhon Rhim, Franco Borsini, ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors, In European Journal of Pharmacology, Volume 661, Issues 1–3, 2011, Pages 8-14.
  2. Rigmor Stain-Malmgren, Bengt F Kjellman, Anna Åberg-Wistedt, Platelet serotonergic functions and light therapy in seasonal affective disorder, In Psychiatry Research, Volume 78, Issue 3, 1998, Pages 163-172.


Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Fresh Lot Days Second Monday in April, August, and December
Label Position Specifically Labeled
Molecular Weight 323.4
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type 5-Hydroxytryptamine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Cardiovascular, Inflammation, Metabolic Disorders, Gastrointestinal
Unit Size 250 µCi